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NO923618L - Benzanilid-derivater - Google Patents

Benzanilid-derivater

Info

Publication number
NO923618L
NO923618L NO92923618A NO923618A NO923618L NO 923618 L NO923618 L NO 923618L NO 92923618 A NO92923618 A NO 92923618A NO 923618 A NO923618 A NO 923618A NO 923618 L NO923618 L NO 923618L
Authority
NO
Norway
Prior art keywords
group
alkyl
hydrogen atom
alkoxy
hydroxy
Prior art date
Application number
NO92923618A
Other languages
English (en)
Other versions
NO923618D0 (no
Inventor
Alexander William Oxford
William Leonard Mitchell
John Bradshaw
John Watson Clitherow
Malcolm Carter
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919119931A external-priority patent/GB9119931D0/en
Priority claimed from GB929205338A external-priority patent/GB9205338D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO923618D0 publication Critical patent/NO923618D0/no
Publication of NO923618L publication Critical patent/NO923618L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/107—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with two aryl or substituted aryl radicals attached in positions 2 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives fremstilling av forbindelser med formel: COKH G) eller et fysiologisk akseptabelt salt eller solvat derav, hvor R utgjør et hydrogenatom eller et halogenatom eller en gruppe .valgt fra C-_6alkyl og C, ,alkoksy; R2 utgjør en fer.ylgruppe substituert med gruppe valgt fra R' N-N II X) og og eventuelt ytterligere substituert med en eller to substituenter valgt fra halogenatomer, CA ,alkoksy, hydroksy 3 J-~D og C, ,alkyl; R utgjør gruppen 4 5 R og R , som kan være like eller forskjellige, utgjør uavhengig av hverandre, et hydrogenatom eller et halogenatom, eller en gruppe valgt fra hydroksy, C. ealkoksy og C, ,alkyl; 6 " "" "" 9 10 R utgjør et hydrogenatom eller en gruppe valgt fra -NR R og en C._6alkylgruppe eventuelt substituert med en eller to substituenter valgt fra c. ,alkoksy, hydroksy, C. ,acyloksy og 11 7 8 9 _oo n . R° og R , som kan være like eller forskjellige, -S02R R' utgjør uavhengig av hverandre, et hydrogenatom eller en C, -alkylgruppe; R utgjør et hydrogenatom eller en gruppe 11 valgt fra C,,alkyl, C, ,acyl, benzoyl og -SO_R ; R utgjør en C, -alkylgruppe eller en fenylgruppe; o Z utgjør et oksygenatom eller en gruppe valgt fra NR og S(0)k; og k står for null, l eller 2. Forbindelsene kan benyttes ved behandling eller fore- byggelse av depresjon og andre CNS-forstyrrelser.
NO92923618A 1991-09-18 1992-09-17 Benzanilid-derivater NO923618L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919119931A GB9119931D0 (en) 1991-09-18 1991-09-18 Chemical compounds
GB929205338A GB9205338D0 (en) 1992-03-12 1992-03-12 Chemical compounds

Publications (2)

Publication Number Publication Date
NO923618D0 NO923618D0 (no) 1992-09-17
NO923618L true NO923618L (no) 1993-03-19

Family

ID=26299553

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923618A NO923618L (no) 1991-09-18 1992-09-17 Benzanilid-derivater

Country Status (26)

Country Link
US (2) US5340810A (no)
EP (1) EP0533268B1 (no)
JP (1) JP3295143B2 (no)
KR (1) KR930006011A (no)
CN (1) CN1071919A (no)
AP (1) AP303A (no)
AT (1) ATE204262T1 (no)
AU (1) AU656021B2 (no)
CA (1) CA2078505A1 (no)
CZ (1) CZ285492A3 (no)
DE (1) DE69232003T2 (no)
DK (1) DK0533268T3 (no)
ES (1) ES2162792T3 (no)
FI (1) FI924160A7 (no)
HU (1) HUT65608A (no)
IL (1) IL103198A (no)
IS (1) IS1618B (no)
MX (1) MX9205280A (no)
MY (1) MY130233A (no)
NO (1) NO923618L (no)
NZ (1) NZ244373A (no)
OA (1) OA10049A (no)
PL (1) PL295960A1 (no)
PT (1) PT533268E (no)
RU (1) RU2077535C1 (no)
TW (1) TW224097B (no)

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JPH06116251A (ja) 1994-04-26
IL103198A (en) 1996-06-18
AU656021B2 (en) 1995-01-19
AP303A (en) 1994-01-28
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HU9202968D0 (en) 1992-12-28
CN1071919A (zh) 1993-05-12
KR930006011A (ko) 1993-04-20
HUT65608A (en) 1994-07-28
FI924160A0 (fi) 1992-09-17
PT533268E (pt) 2002-02-28
CA2078505A1 (en) 1993-03-19
IS3915A (is) 1993-03-19
EP0533268A1 (en) 1993-03-24
NO923618D0 (no) 1992-09-17
OA10049A (en) 1996-10-14
ATE204262T1 (de) 2001-09-15
NZ244373A (en) 1995-03-28
US5340810A (en) 1994-08-23
TW224097B (no) 1994-05-21
DE69232003D1 (de) 2001-09-20
EP0533268B1 (en) 2001-08-16
IS1618B (is) 1996-10-18
DK0533268T3 (da) 2001-12-03
RU2077535C1 (ru) 1997-04-20
ES2162792T3 (es) 2002-01-16
FI924160A7 (fi) 1993-03-19
MY130233A (en) 2007-06-29
MX9205280A (es) 1993-03-01
AU2453092A (en) 1993-03-25
US5510350A (en) 1996-04-23
PL295960A1 (en) 1993-09-06
IL103198A0 (en) 1993-02-21
AP9200427A0 (en) 1992-10-31
DE69232003T2 (de) 2002-04-25
CZ285492A3 (en) 1993-04-14

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