NO924321L - Synergistiske terapeutiske blandinger og fremgangsmaater - Google Patents

Synergistiske terapeutiske blandinger og fremgangsmaater

Info

Publication number: NO924321L
Authority: NO; Norway
Prior art keywords: mammal; synergistic; angiotensin; blood pressure; heart failure
Prior art date: 1990-05-11

Application number

NO92924321A

Other languages

English (en)

Norwegian (no)

Other versions

NO924321D0 (no

Inventor

Anthony Andrea Fossa

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1992-11-10

Publication date

1993-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24080550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO924321(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-11-10 Application filed by Pfizer filed Critical Pfizer

1992-11-10 Publication of NO924321D0 publication Critical patent/NO924321D0/no

1993-01-08 Publication of NO924321L publication Critical patent/NO924321L/no

Links

230000002195 synergetic effect Effects 0.000 title abstract 5
230000001225 therapeutic effect Effects 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 3
241000124008 Mammalia Species 0.000 abstract 4
206010019280 Heart failures Diseases 0.000 abstract 3
230000036772 blood pressure Effects 0.000 abstract 3
229940123413 Angiotensin II antagonist Drugs 0.000 abstract 2
239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
239000002532 enzyme inhibitor Substances 0.000 abstract 2
229940125532 enzyme inhibitor Drugs 0.000 abstract 2
239000002461 renin inhibitor Substances 0.000 abstract 2
229940086526 renin-inhibitors Drugs 0.000 abstract 2
235000013547 stew Nutrition 0.000 abstract 2
229940124597 therapeutic agent Drugs 0.000 abstract 2
101800000734 Angiotensin-1 Proteins 0.000 abstract 1
102400000344 Angiotensin-1 Human genes 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO92924321A 1990-05-11 1992-11-10 Synergistiske terapeutiske blandinger og fremgangsmaater NO924321L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52236090A	1990-05-11	1990-05-11
PCT/US1991/002733 WO1991017771A1 (en)	1990-05-11	1991-04-22	Synergistic therapeutic compositions and methods

Publications (2)

Publication Number	Publication Date
NO924321D0 NO924321D0 (no)	1992-11-10
NO924321L true NO924321L (no)	1993-01-08

Family

ID=24080550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO92924321A NO924321L (no)	1990-05-11	1992-11-10	Synergistiske terapeutiske blandinger og fremgangsmaater

Country Status (33)

Country	Link
US (2)	US6900234B1 (is)
EP (1)	EP0527879B1 (is)
JP (2)	JPH0729938B2 (is)
KR (1)	KR970005839B1 (is)
CN (7)	CN101156949A (is)
AP (1)	AP240A (is)
AT (1)	ATE148632T1 (is)
AU (1)	AU653724B2 (is)
BG (1)	BG61831B1 (is)
BR (1)	BR9106438A (is)
CA (1)	CA2081564C (is)
DE (1)	DE69124598T2 (is)
DK (1)	DK0527879T3 (is)
EG (1)	EG19648A (is)
ES (1)	ES2097208T3 (is)
GR (1)	GR3022997T3 (is)
GT (1)	GT199100032A (is)
HU (1)	HU227346B1 (is)
IE (1)	IE911592A1 (is)
IL (1)	IL98055A (is)
IS (1)	IS2042B (is)
MA (1)	MA22150A1 (is)
MY (1)	MY114347A (is)
NO (1)	NO924321L (is)
NZ (1)	NZ238118A (is)
PE (1)	PE30891A1 (is)
PT (1)	PT97615B (is)
RO (1)	RO115786B1 (is)
RU (1)	RU2147875C1 (is)
TW (1)	TW203553B (is)
WO (1)	WO1991017771A1 (is)
YU (1)	YU49094B (is)
ZA (1)	ZA913539B (is)

Families Citing this family (35)

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ES2097208T3 (es) *	1990-05-11	1997-04-01	Pfizer	Composiciones y procedimientos terapeuticos y sinergicos.
EP0629408A1 (en) *	1993-06-16	1994-12-21	LABORATOIRES MERCK, SHARP & DOHME-CHIBRET	Combination of angiotensin converting enzyme inhibitors and AII antagonists
DE4340437C1 (de) *	1993-11-27	1995-05-24	Karla Dr Lehmann	Verwendung von Lithiumverbindungen zur Behandlung von Herzinsuffizienz einschließlich ihrer Folgeerkrankungen
KR19980703647A (ko) *	1995-04-07	1998-12-05	베르너발데크	베나제프릴 또는 베나제프릴라트 및 발사르탄을 함유하는조성물
CA2224451A1 (en) *	1995-06-30	1997-01-23	Merck & Co., Inc.	Method of treating renal disease using an ace inhibitor and an aii antagonist
ES2175385T5 (es) *	1996-04-05	2006-06-01	Takeda Chemical Industries, Ltd.	Combinacion farmaceutica que contiene un compuesto que tiene actividad antagonista de angiotensina ii y un compuesto que aumenta la sensibilidad a la insulina.
DE69712338T2 (de) *	1996-06-24	2002-11-07	Merck & Co., Inc.	Zusammensetzung auf basis von enalapril und losartan
US6087386A (en) *	1996-06-24	2000-07-11	Merck & Co., Inc.	Composition of enalapril and losartan
US6248724B1 (en)	1997-09-25	2001-06-19	University Of Florida	Antisense oligonucleotide compositions targeted to angiotensin converting enzyme MRNA and methods of use
KR20010033473A (ko) *	1997-12-23	2001-04-25	로즈 암스트롱, 크리스틴 에이. 트러트웨인	Ａｃｅ 저해제-ｍｍｐ 저해제의 병용 제제
US6087343A (en) *	1998-09-14	2000-07-11	University Of Florida	Antisense oligonucleotides targeted to β-1 adrenoceptor and methods of use
US6387894B1 (en) *	1999-06-11	2002-05-14	Pfizer Inc.	Use of CRF antagonists and renin-angiotensin system inhibitors
US8168616B1 (en) *	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US20060013852A1 (en) *	2002-06-28	2006-01-19	Prescott Margaret F	Use of organic compounds
CN104383542B (zh)	2003-04-08	2017-09-26	普罗热尼奇制药公司	包含甲基纳曲酮的药物配方
US20040265238A1 (en)	2003-06-27	2004-12-30	Imtiaz Chaudry	Inhalable formulations for treating pulmonary hypertension and methods of using same
EP1799199B1 (en) *	2004-10-08	2012-03-28	Novartis AG	Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
US9662325B2 (en)	2005-03-07	2017-05-30	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) *	2005-03-07	2014-09-17	芝加哥大学	阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8518962B2 (en)	2005-03-07	2013-08-27	The University Of Chicago	Use of opioid antagonists
US8524731B2 (en)	2005-03-07	2013-09-03	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es)	2005-05-25	2007-11-14	Progenics Pharm Inc	SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es)	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh)	2006-08-04	2015-07-01	Wyeth Corp	用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) *	2006-09-08	2008-04-16	Wyeth Corp	Dry powder compound formulations and uses thereof
CL2007002689A1 (es)	2006-09-18	2008-04-18	Vitae Pharmaceuticals Inc	Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
PL2137191T3 (pl)	2007-03-29	2016-12-30		Antagoniści obwodowego receptora opioidowego i ich zastosowania
WO2008121352A2 (en)	2007-03-29	2008-10-09	Progenics Pharmaceuticals, Inc.	Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof
DK2139890T3 (da)	2007-03-29	2014-08-25	Wyeth Llc	Perifere opioidreceptor-antagonister og anvendelser deraf
KR101581480B1 (ko)	2008-02-06	2015-12-30	프로제닉스 파머슈티컬스, 인코포레이티드	(ｒ),(ｒ)-2,2'-비스-메틸날트렉손의 제조법 및 용도
EP2278966B1 (en)	2008-03-21	2019-10-09	The University of Chicago	Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en)	2008-09-30	2017-04-25	Wyeth	Peripheral opioid receptor antagonists and uses thereof
AR077692A1 (es)	2009-08-06	2011-09-14	Vitae Pharmaceuticals Inc	Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
CN102423483A (zh) *	2011-11-24	2012-04-25	西北农林科技大学	一种复方雷米普利纳米乳抗高血压药物
CN114032273B (zh) *	2021-11-17	2024-02-02	山东省科学院生物研究所	一种多功能西洋参水解肽及其制备方法和应用

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IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4749688A (en)	1986-06-20	1988-06-07	Schering Corporation	Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1334092C (en)	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
DE3633861A1 (de) *	1986-10-04	1988-04-07	Thomae Gmbh Dr K	Neue imidazo-benzoxazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
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US4895834A (en) *	1986-12-15	1990-01-23	Warner-Lambert Company	Renin inhibitors III
US4874759A (en) *	1987-01-23	1989-10-17	Yoshitomi Pharmaceutical Industries, Ltd.	5-Hydroxyindole-3-carboxylic acid amide compounds, pharmaceutical compositions and use
US4962105A (en)	1987-10-19	1990-10-09	Ciba-Geigy Corporation	Potentiation of antihypertensive effect of ace inhibitors
US5015651A (en)	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
CA1338238C (en)	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
IL91780A (en)	1988-10-04	1995-08-31	Abbott Lab	History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
ES2097208T3 (es) *	1990-05-11	1997-04-01	Pfizer	Composiciones y procedimientos terapeuticos y sinergicos.

1991
- 1991-04-22 ES ES91909382T patent/ES2097208T3/es not_active Expired - Lifetime
- 1991-04-22 JP JP3508991A patent/JPH0729938B2/ja not_active Expired - Lifetime
- 1991-04-22 AU AU78591/91A patent/AU653724B2/en not_active Expired
- 1991-04-22 KR KR1019920702805A patent/KR970005839B1/ko not_active Expired - Lifetime
- 1991-04-22 CA CA002081564A patent/CA2081564C/en not_active Expired - Lifetime
- 1991-04-22 WO PCT/US1991/002733 patent/WO1991017771A1/en not_active Ceased
- 1991-04-22 DK DK91909382.3T patent/DK0527879T3/da active
- 1991-04-22 AT AT91909382T patent/ATE148632T1/de not_active IP Right Cessation
- 1991-04-22 RU RU92016534A patent/RU2147875C1/ru active
- 1991-04-22 RO RO92-01405A patent/RO115786B1/ro unknown
- 1991-04-22 DE DE69124598T patent/DE69124598T2/de not_active Expired - Lifetime
- 1991-04-22 EP EP91909382A patent/EP0527879B1/en not_active Expired - Lifetime
- 1991-04-22 BR BR919106438A patent/BR9106438A/pt not_active Application Discontinuation
- 1991-04-22 HU HU9203522A patent/HU227346B1/hu unknown
- 1991-05-01 TW TW080103439A patent/TW203553B/zh not_active IP Right Cessation
- 1991-05-03 IL IL9805591A patent/IL98055A/en not_active IP Right Cessation
- 1991-05-06 AP APAP/P/1991/000258A patent/AP240A/en active
- 1991-05-08 EG EG27891A patent/EG19648A/xx active
- 1991-05-08 MA MA22420A patent/MA22150A1/fr unknown
- 1991-05-09 PT PT97615A patent/PT97615B/pt not_active IP Right Cessation
- 1991-05-10 GT GT199100032A patent/GT199100032A/es unknown
- 1991-05-10 MY MYPI91000798A patent/MY114347A/en unknown
- 1991-05-10 ZA ZA913539A patent/ZA913539B/xx unknown
- 1991-05-10 CN CNA2007101867127A patent/CN101156949A/zh active Pending
- 1991-05-10 IE IE159291A patent/IE911592A1/en not_active IP Right Cessation
- 1991-05-10 CN CNA2006100934632A patent/CN1879884A/zh active Pending
- 1991-05-10 CN CN2005100035730A patent/CN1824315B/zh not_active Expired - Lifetime
- 1991-05-10 CN CNA2006101018493A patent/CN1915428A/zh active Pending
- 1991-05-10 IS IS3703A patent/IS2042B/is unknown
- 1991-05-10 NZ NZ238118A patent/NZ238118A/en unknown
- 1991-05-10 PE PE1991185538A patent/PE30891A1/es unknown
- 1991-05-10 CN CN91103177A patent/CN1065140C/zh not_active Expired - Lifetime
- 1991-05-10 CN CNB2003101199156A patent/CN100358578C/zh not_active Expired - Lifetime
- 1991-05-10 YU YU81991A patent/YU49094B/sh unknown
1992
- 1992-11-10 BG BG97068A patent/BG61831B1/bg unknown
- 1992-11-10 NO NO92924321A patent/NO924321L/no unknown
1994
- 1994-06-27 JP JP6144998A patent/JP2635291B2/ja not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,878 patent/US6900234B1/en not_active Expired - Lifetime
- 1995-06-05 US US08/465,660 patent/US6716875B1/en not_active Expired - Lifetime
1997
- 1997-04-01 GR GR970400671T patent/GR3022997T3/el unknown
2000
- 2000-04-29 CN CN00108186A patent/CN1307901A/zh active Pending

Also Published As

Publication number	Publication date
RU2147875C1 (ru)	2000-04-27
BG61831B1 (bg)	1998-07-31
RO115786B1 (ro)	2000-06-30
NZ238118A (en)	1997-06-24
CA2081564C (en)	1998-02-03
CN1824315A (zh)	2006-08-30
BG97068A (bg)	1993-12-24
IL98055A (en)	1996-10-31
CN1824315B (zh)	2011-01-12
WO1991017771A1 (en)	1991-11-28
IE911592A1 (en)	1991-11-20
JPH05505618A (ja)	1993-08-19
YU49094B (sh)	2003-12-31
CA2081564A1 (en)	1991-11-12
ATE148632T1 (de)	1997-02-15
KR970005839B1 (ko)	1997-04-21
ZA913539B (en)	1992-12-30
US6716875B1 (en)	2004-04-06
IL98055A0 (en)	1992-06-21
JPH0748280A (ja)	1995-02-21
DK0527879T3 (da)	1997-07-14
DE69124598T2 (de)	1997-05-28
EP0527879B1 (en)	1997-02-05
CN1915428A (zh)	2007-02-21
NO924321D0 (no)	1992-11-10
CN1879884A (zh)	2006-12-20
ES2097208T3 (es)	1997-04-01
US6900234B1 (en)	2005-05-31
BR9106438A (pt)	1993-05-18
CN101156949A (zh)	2008-04-09
HU227346B1 (en)	2011-04-28
MY114347A (en)	2002-10-31
AU7859191A (en)	1991-12-10
EP0527879A1 (en)	1993-02-24
HUT62804A (en)	1993-06-28
GR3022997T3 (en)	1997-07-30
MA22150A1 (fr)	1991-12-31
CN1307901A (zh)	2001-08-15
DE69124598D1 (de)	1997-03-20
AP240A (en)	1993-02-18
PT97615A (pt)	1992-03-31
GT199100032A (es)	1992-10-31
AP9100258A0 (en)	1991-07-31
CN1065140C (zh)	2001-05-02
JP2635291B2 (ja)	1997-07-30
CN1056426A (zh)	1991-11-27
PE30891A1 (es)	1991-11-27
HU9203522D0 (en)	1993-01-28
EG19648A (en)	1995-09-30
JPH0729938B2 (ja)	1995-04-05
TW203553B (is)	1993-04-11
HK1094148A1 (en)	2007-03-23
AU653724B2 (en)	1994-10-13
CN100358578C (zh)	2008-01-02
CN1502370A (zh)	2004-06-09
YU81991A (sh)	1994-06-24
PT97615B (pt)	1998-08-31
IS2042B (is)	2005-09-15
IS3703A7 (is)	1991-11-12

Publication	Publication Date	Title
NO924321L (no)	1993-01-08	Synergistiske terapeutiske blandinger og fremgangsmaater
RU92016534A (ru)	1995-06-19	Синергетические терапевтические композиции и способы достижения синергетического терапевтического эффекта
NO923130L (no)	1993-02-15	Behandling av kongestiv hjertesvikt
NO20055863L (no)	2001-09-12	W-karboksyarylsubstituerte difenylureaforbindelser som raf-kinaseinhibitorer
NO920298L (no)	1992-07-31	2,3,6-substituerte kinazolinoner
AU3664401A (en)	2001-08-14	Platelet adp receptor inhibitors
NO20052595L (no)	2005-06-27	Sammensetninger anvendelige som inhibitorer av ROCK- og andre proteinkinaser.
NO20072286L (no)	2007-05-02	Hemming av HCV NS3-NS4A-protease
BR0212252A (pt)	2004-09-14	Métodos para reduzir a hipertensão e a insuficiência cardìaca em um mamìfero
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