NO326366B1 - Imidazolderivater, farmasoytiske preparater inneholdende slike samt deres fremstilling - Google Patents

Imidazolderivater, farmasoytiske preparater inneholdende slike samt deres fremstilling Download PDF

Info

Publication number: NO326366B1
Authority: NO; Norway
Prior art keywords: group; compound; formula; salt; pyrrolo
Prior art date: 2000-11-17

Application number

NO20032234A

Other languages

English (en)

Norwegian (no)

Other versions

NO20032234D0 (no

NO20032234L (no

Inventor

Takenori Hitaka

Akihiro Tasaka

Isao Aoki

Nobuyuki Matsunaga

Masami Kusaka

Mari Adachi

Akio Ojida

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2003-05-16

Publication date

2008-11-17

2003-05-16 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2003-05-16 Publication of NO20032234D0 publication Critical patent/NO20032234D0/no

2003-07-16 Publication of NO20032234L publication Critical patent/NO20032234L/no

2008-11-17 Publication of NO326366B1 publication Critical patent/NO326366B1/no

Links

238000002360 preparation method Methods 0.000 title claims description 78
239000000825 pharmaceutical preparation Substances 0.000 title claims description 25
150000002460 imidazoles Chemical class 0.000 title description 4
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 266
150000003839 salts Chemical class 0.000 claims description 114
239000000203 mixture Substances 0.000 claims description 113
239000002253 acid Substances 0.000 claims description 45
238000000034 method Methods 0.000 claims description 41
125000005843 halogen group Chemical group 0.000 claims description 31
OZPFIJIOIVJZMN-UHFFFAOYSA-N 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide Chemical compound C1=CC2=CC(C(=O)NC)=CC=C2C=C1C1(O)C2=CN=CN2CC1 OZPFIJIOIVJZMN-UHFFFAOYSA-N 0.000 claims description 27
230000003287 optical effect Effects 0.000 claims description 27
125000000217 alkyl group Chemical group 0.000 claims description 26
125000004432 carbon atom Chemical group C* 0.000 claims description 17
125000006239 protecting group Chemical group 0.000 claims description 16
239000003098 androgen Substances 0.000 claims description 15
239000003795 chemical substances by application Substances 0.000 claims description 14
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 13
239000000460 chlorine Substances 0.000 claims description 13
229910052801 chlorine Inorganic materials 0.000 claims description 13
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 12
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GIYVJBCEIATHSN-UHFFFAOYSA-N 7-[4-(4-fluorophenyl)phenyl]-5,6-dihydropyrrolo[1,2-c]imidazol-7-ol Chemical compound C1CN2C=NC=C2C1(O)C(C=C1)=CC=C1C1=CC=C(F)C=C1 GIYVJBCEIATHSN-UHFFFAOYSA-N 0.000 claims description 10
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XPDAYTAXTQFSDQ-UHFFFAOYSA-N 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)naphthalene-2-carboxamide Chemical compound C1=CC2=CC(C(=O)N)=CC=C2C=C1C1(O)C2=CN=CN2CC1 XPDAYTAXTQFSDQ-UHFFFAOYSA-N 0.000 claims description 8
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238000007363 ring formation reaction Methods 0.000 claims description 3
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125000005236 alkanoylamino group Chemical group 0.000 claims description 2
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230000000259 anti-tumor effect Effects 0.000 claims 1
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MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 14
239000002585 base Substances 0.000 description 14
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

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General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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NO20032234A 2000-11-17 2003-05-16 Imidazolderivater, farmasoytiske preparater inneholdende slike samt deres fremstilling NO326366B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2000351780		2000-11-17
JP2001247618		2001-08-17
JP2001336880		2001-11-01
PCT/JP2001/010002 WO2002040484A2 (en)	2000-11-17	2001-11-16	Novel imidazole derivatives, production method thereof and use thereof

Publications (3)

Publication Number	Publication Date
NO20032234D0 NO20032234D0 (no)	2003-05-16
NO20032234L NO20032234L (no)	2003-07-16
NO326366B1 true NO326366B1 (no)	2008-11-17

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Application Number	Title	Priority Date	Filing Date
NO20032234A NO326366B1 (no)	2000-11-17	2003-05-16	Imidazolderivater, farmasoytiske preparater inneholdende slike samt deres fremstilling

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US (1)	US7141598B2 (es)
EP (2)	EP1681290B9 (es)
JP (2)	JP3753971B2 (es)
KR (3)	KR100809899B1 (es)
CN (3)	CN100572363C (es)
AR (1)	AR034854A1 (es)
AT (2)	ATE533768T1 (es)
AU (3)	AU2002214296C1 (es)
BR (1)	BR0115306B1 (es)
CA (1)	CA2429133C (es)
CY (1)	CY1105423T1 (es)
DE (1)	DE60119963T2 (es)
DK (1)	DK1334106T3 (es)
ES (1)	ES2260303T3 (es)
HU (1)	HU229408B1 (es)
IL (2)	IL155624A0 (es)
MX (1)	MXPA03004347A (es)
MY (1)	MY134929A (es)
NO (1)	NO326366B1 (es)
NZ (1)	NZ526387A (es)
PE (1)	PE20020596A1 (es)
PL (1)	PL204934B1 (es)
PT (1)	PT1334106E (es)
SI (1)	SI1334106T1 (es)
TW (1)	TWI306099B (es)
WO (1)	WO2002040484A2 (es)

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JP4745616B2 (ja) *	2003-02-26	2011-08-10	武田薬品工業株式会社	安定化されたイミダゾール誘導体含有医薬組成物、イミダゾール誘導体の安定化方法
WO2004075890A1 (ja) *	2003-02-26	2004-09-10	Takeda Pharmaceutical Company	安定化されたイミダゾール誘導体含有医薬組成物、イミダゾ－ル誘導体の安定化方法
CA2519211A1 (en) *	2003-03-17	2004-09-30	Takeda Pharmaceutical Company Limited	Release control compositions
JP4837895B2 (ja) *	2003-03-17	2011-12-14	武田薬品工業株式会社	放出制御組成物
US7282507B2 (en) *	2004-05-03	2007-10-16	Janssen Pharmaceutica N.V.	Indole derivatives as selective androgen receptor modulators (SARMS)
AR049125A1 (es) *	2004-05-28	2006-06-28	Speedel Experimenta Ag	Heterociclos biciclicos nitrogenados inhibidores de la aromatasa.
US8828429B2 (en)	2005-03-03	2014-09-09	Takeda Pharmaceutical Company Limited	Release-control composition
GT200600381A (es) *	2005-08-25	2007-03-28		Compuestos organicos
TW200804378A (en)	2005-12-09	2008-01-16	Speedel Experimenta Ag	Organic compounds
JP5230448B2 (ja) *	2006-02-10	2013-07-10	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	選択的アンドローゲン受容体モジュレーターとして有用な新イミダゾロピラゾール誘導体
AR060225A1 (es) *	2006-03-31	2008-06-04	Speedel Experimenta Ag	Proceso para preparar 6,7- dihidro-5h-imidazo (1,5-a) piridin -8- ona
AU2008319767B8 (en) *	2007-10-29	2014-01-09	Takeda Pharmaceutical Company Limited	Pyrrolo [1,2-C] imidazole derivatives for use in the prophylaxis or treatment of cancer which is refractory to known cancer therapies
JOP20190230A1 (ar)	2009-01-15	2017-06-16	Incyte Corp	طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
UY33740A (es) *	2010-11-18	2012-05-31	Takeda Pharmaceutical	Método para tratar el cáncer de mama y cáncer de ovarios
EA201391447A1 (ru)	2011-04-01	2014-02-28	Такеда Фармасьютикал Компани Лимитед	Твердая композиция
CA2838971C (en)	2011-06-15	2019-07-30	Takeda Pharmaceutical Company Limited	Production method of imidazole derivatives

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AU6015796A (en)	1995-06-14	1997-01-15	Yamanouchi Pharmaceutical Co., Ltd.	Fused imidazole derivatives and medicinal composition thereof
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ATE264304T1 (de)	1997-10-02	2004-04-15	Daiichi Seiyaku Co	Dihydronaphthalinderivate und verfahren zur herstellung derselben
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PE20010781A1 (es) *	1999-10-22	2001-08-08	Takeda Chemical Industries Ltd	Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion

2001
- 2001-11-16 CA CA002429133A patent/CA2429133C/en not_active Expired - Fee Related
- 2001-11-16 IL IL15562401A patent/IL155624A0/xx active IP Right Grant
- 2001-11-16 SI SI200130590T patent/SI1334106T1/sl unknown
- 2001-11-16 AT AT05077705T patent/ATE533768T1/de active
- 2001-11-16 EP EP05077705.1A patent/EP1681290B9/en not_active Expired - Lifetime
- 2001-11-16 AU AU2002214296A patent/AU2002214296C1/en not_active Ceased
- 2001-11-16 MX MXPA03004347A patent/MXPA03004347A/es active IP Right Grant
- 2001-11-16 EP EP01982800A patent/EP1334106B1/en not_active Expired - Lifetime
- 2001-11-16 PL PL362766A patent/PL204934B1/pl unknown
- 2001-11-16 TW TW090128440A patent/TWI306099B/zh not_active IP Right Cessation
- 2001-11-16 DE DE60119963T patent/DE60119963T2/de not_active Expired - Lifetime
- 2001-11-16 HU HU0400549A patent/HU229408B1/hu not_active IP Right Cessation
- 2001-11-16 NZ NZ526387A patent/NZ526387A/en not_active IP Right Cessation
- 2001-11-16 JP JP2001351035A patent/JP3753971B2/ja not_active Expired - Fee Related
- 2001-11-16 DK DK01982800T patent/DK1334106T3/da active
- 2001-11-16 CN CNB2005100640723A patent/CN100572363C/zh not_active Expired - Fee Related
- 2001-11-16 PE PE2001001147A patent/PE20020596A1/es active IP Right Grant
- 2001-11-16 ES ES01982800T patent/ES2260303T3/es not_active Expired - Lifetime
- 2001-11-16 BR BRPI0115306-4B1A patent/BR0115306B1/pt not_active IP Right Cessation
- 2001-11-16 CN CNA200610100666XA patent/CN1900079A/zh active Pending
- 2001-11-16 AR ARP010105365A patent/AR034854A1/es active IP Right Grant
- 2001-11-16 AU AU1429602A patent/AU1429602A/xx active Pending
- 2001-11-16 KR KR1020057018247A patent/KR100809899B1/ko not_active Expired - Fee Related
- 2001-11-16 KR KR1020037006727A patent/KR100725442B1/ko not_active Expired - Fee Related
- 2001-11-16 MY MYPI20015279A patent/MY134929A/en unknown
- 2001-11-16 PT PT01982800T patent/PT1334106E/pt unknown
- 2001-11-16 CN CNB018190251A patent/CN1329394C/zh not_active Expired - Fee Related
- 2001-11-16 KR KR1020077025704A patent/KR20080002929A/ko not_active Withdrawn
- 2001-11-16 AT AT01982800T patent/ATE327237T1/de active
- 2001-11-16 US US10/416,986 patent/US7141598B2/en not_active Expired - Lifetime
- 2001-11-16 WO PCT/JP2001/010002 patent/WO2002040484A2/en not_active Ceased
2003
- 2003-04-28 IL IL155624A patent/IL155624A/en not_active IP Right Cessation
- 2003-05-16 NO NO20032234A patent/NO326366B1/no not_active IP Right Cessation
2005
- 2005-08-31 JP JP2005252651A patent/JP4427496B2/ja not_active Expired - Fee Related
- 2005-10-18 AU AU2005225035A patent/AU2005225035B2/en not_active Ceased
2006
- 2006-06-26 CY CY20061100867T patent/CY1105423T1/el unknown

Also Published As

Publication number	Publication date
DE60119963D1 (de)	2006-06-29
HK1056168A1 (en)	2004-02-06
NO20032234D0 (no)	2003-05-16
JP2003201282A (ja)	2003-07-18
EP1681290B9 (en)	2013-06-19
CN1680336A (zh)	2005-10-12
JP2006045239A (ja)	2006-02-16
HUP0400549A2 (hu)	2004-06-28
NZ526387A (en)	2004-02-27
HUP0400549A3 (en)	2004-09-28
BR0115306A (pt)	2004-02-10
PE20020596A1 (es)	2002-08-13
PT1334106E (pt)	2006-08-31
ATE327237T1 (de)	2006-06-15
WO2002040484A3 (en)	2002-09-26
KR20030048156A (ko)	2003-06-18
KR20050105287A (ko)	2005-11-03
EP1681290A2 (en)	2006-07-19
PL362766A1 (en)	2004-11-02
AU2005225035A1 (en)	2005-11-10
CA2429133A1 (en)	2002-05-23
US7141598B2 (en)	2006-11-28
EP1681290A3 (en)	2006-07-26
CN1900079A (zh)	2007-01-24
AU2002214296C1 (en)	2006-04-13
CN1329394C (zh)	2007-08-01
ATE533768T1 (de)	2011-12-15
TWI306099B (en)	2009-02-11
EP1681290B1 (en)	2011-11-16
PL204934B1 (pl)	2010-02-26
AU2005225035B2 (en)	2007-02-22
AU1429602A (en)	2002-05-27
KR100809899B1 (ko)	2008-03-10
CN100572363C (zh)	2009-12-23
HU229408B1 (hu)	2013-12-30
WO2002040484A2 (en)	2002-05-23
AU2002214296B2 (en)	2005-09-29
KR20080002929A (ko)	2008-01-04
ES2260303T3 (es)	2006-11-01
US20040033935A1 (en)	2004-02-19
EP1334106B1 (en)	2006-05-24
JP3753971B2 (ja)	2006-03-08
BR0115306B1 (pt)	2013-12-24
MXPA03004347A (es)	2004-05-04
CA2429133C (en)	2009-08-18
KR100725442B1 (ko)	2007-06-07
DE60119963T2 (de)	2006-10-05
IL155624A0 (en)	2003-11-23
NO20032234L (no)	2003-07-16
CN1474819A (zh)	2004-02-11
SI1334106T1 (sl)	2006-10-31
CY1105423T1 (el)	2010-04-28
AR034854A1 (es)	2004-03-24
IL155624A (en)	2006-12-31
DK1334106T3 (da)	2006-09-18
MY134929A (en)	2008-01-31
EP1334106A2 (en)	2003-08-13
JP4427496B2 (ja)	2010-03-10

Publication	Publication Date	Title
NO326366B1 (no)	2008-11-17	Imidazolderivater, farmasoytiske preparater inneholdende slike samt deres fremstilling
EP2118111B1 (en)	2011-03-23	2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer
EP1222174B1 (en)	2009-05-27	Imidazol-4-ylmethanols used as inhibitors of steroid c17-20 lyase
AU2002214296A1 (en)	2002-08-01	Novel imidazole derivatives, production method thereof and use thereof
HUP0300028A2 (en)	2003-05-28	Thienopyridine derivatives, their production and use and pharmaceutical compositions containing them
CA2429437A1 (en)	2002-05-23	Imidazole derivatives, process for their preparation and their use
JP2000007658A (ja)	2000-01-11	ナフタレン誘導体
HK1095589A (en)	2007-05-11	Imidazole derivatives, production method thereof and use thereof
JP2002080458A (ja)	2002-03-19	１−置換−１−（１ｈ−イミダゾール−４−イル）メタノール類
HK1056168B (en)	2006-12-08	Imidazole derivatives, production method thereof and use thereof
JP4121268B2 (ja)	2008-07-23	イミダゾール誘導体、その製造法および用途

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