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DE60119963D1 - Imidazol derivate, ihre herstellung und ihre verwendung - Google Patents

Imidazol derivate, ihre herstellung und ihre verwendung

Info

Publication number
DE60119963D1
DE60119963D1 DE60119963T DE60119963T DE60119963D1 DE 60119963 D1 DE60119963 D1 DE 60119963D1 DE 60119963 T DE60119963 T DE 60119963T DE 60119963 T DE60119963 T DE 60119963T DE 60119963 D1 DE60119963 D1 DE 60119963D1
Authority
DE
Germany
Prior art keywords
manufacture
imidazole derivatives
imidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60119963T
Other languages
English (en)
Other versions
DE60119963T2 (de
Inventor
Akihiro Tasaka
Takenori Hitaka
Nobuyuki Matsunaga
Masami Kusaka
Mari Adachi
Isao Aoki
Akio Ojida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of DE60119963D1 publication Critical patent/DE60119963D1/de
Application granted granted Critical
Publication of DE60119963T2 publication Critical patent/DE60119963T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
DE60119963T 2000-11-17 2001-11-16 Imidazol derivate, ihre herstellung und ihre verwendung Expired - Lifetime DE60119963T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2000351780 2000-11-17
JP2000351780 2000-11-17
JP2001247618 2001-08-17
JP2001247618 2001-08-17
JP2001336880 2001-11-01
JP2001336880 2001-11-01
PCT/JP2001/010002 WO2002040484A2 (en) 2000-11-17 2001-11-16 Novel imidazole derivatives, production method thereof and use thereof

Publications (2)

Publication Number Publication Date
DE60119963D1 true DE60119963D1 (de) 2006-06-29
DE60119963T2 DE60119963T2 (de) 2006-10-05

Family

ID=27345219

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60119963T Expired - Lifetime DE60119963T2 (de) 2000-11-17 2001-11-16 Imidazol derivate, ihre herstellung und ihre verwendung

Country Status (26)

Country Link
US (1) US7141598B2 (de)
EP (2) EP1681290B9 (de)
JP (2) JP3753971B2 (de)
KR (3) KR100809899B1 (de)
CN (3) CN100572363C (de)
AR (1) AR034854A1 (de)
AT (2) ATE533768T1 (de)
AU (3) AU2002214296C1 (de)
BR (1) BR0115306B1 (de)
CA (1) CA2429133C (de)
CY (1) CY1105423T1 (de)
DE (1) DE60119963T2 (de)
DK (1) DK1334106T3 (de)
ES (1) ES2260303T3 (de)
HU (1) HU229408B1 (de)
IL (2) IL155624A0 (de)
MX (1) MXPA03004347A (de)
MY (1) MY134929A (de)
NO (1) NO326366B1 (de)
NZ (1) NZ526387A (de)
PE (1) PE20020596A1 (de)
PL (1) PL204934B1 (de)
PT (1) PT1334106E (de)
SI (1) SI1334106T1 (de)
TW (1) TWI306099B (de)
WO (1) WO2002040484A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1471056B1 (de) * 2002-01-10 2012-07-11 Takeda Pharmaceutical Company Limited Verfahren zur herstellung einer kondensierten imidazolverbindung, reformatskyreagens in stabiler form und verfahren zu dessen herstellung
JP4745616B2 (ja) * 2003-02-26 2011-08-10 武田薬品工業株式会社 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾール誘導体の安定化方法
WO2004075890A1 (ja) * 2003-02-26 2004-09-10 Takeda Pharmaceutical Company 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾ－ル誘導体の安定化方法
CA2519211A1 (en) * 2003-03-17 2004-09-30 Takeda Pharmaceutical Company Limited Release control compositions
JP4837895B2 (ja) * 2003-03-17 2011-12-14 武田薬品工業株式会社 放出制御組成物
US7282507B2 (en) * 2004-05-03 2007-10-16 Janssen Pharmaceutica N.V. Indole derivatives as selective androgen receptor modulators (SARMS)
AR049125A1 (es) * 2004-05-28 2006-06-28 Speedel Experimenta Ag Heterociclos biciclicos nitrogenados inhibidores de la aromatasa.
US8828429B2 (en) 2005-03-03 2014-09-09 Takeda Pharmaceutical Company Limited Release-control composition
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
TW200804378A (en) 2005-12-09 2008-01-16 Speedel Experimenta Ag Organic compounds
JP5230448B2 (ja) * 2006-02-10 2013-07-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドローゲン受容体モジュレーターとして有用な新イミダゾロピラゾール誘導体
AR060225A1 (es) * 2006-03-31 2008-06-04 Speedel Experimenta Ag Proceso para preparar 6,7- dihidro-5h-imidazo (1,5-a) piridin -8- ona
AU2008319767B8 (en) * 2007-10-29 2014-01-09 Takeda Pharmaceutical Company Limited Pyrrolo [1,2-C] imidazole derivatives for use in the prophylaxis or treatment of cancer which is refractory to known cancer therapies
JOP20190230A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
UY33740A (es) * 2010-11-18 2012-05-31 Takeda Pharmaceutical Método para tratar el cáncer de mama y cáncer de ovarios
EA201391447A1 (ru) 2011-04-01 2014-02-28 Такеда Фармасьютикал Компани Лимитед Твердая композиция
CA2838971C (en) 2011-06-15 2019-07-30 Takeda Pharmaceutical Company Limited Production method of imidazole derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
NZ221729A (en) 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
AU606677B2 (en) 1987-04-22 1991-02-14 Merrell Dow Pharmaceuticals Inc. 17 beta -(cyclopropylimino) androst-5-EN-3 beta- Ol and related compounds useful as C17-20 lyase inhibitors
US5057521A (en) * 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
US4966898A (en) 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
WO1992015404A1 (en) 1991-03-01 1992-09-17 S.L. Electrostatic Technology, Inc. Powder coating method for producing circuit board laminae and the like
US5457102A (en) 1994-07-07 1995-10-10 Janssen Pharmaceutica, N.V. Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives
PT625155E (pt) * 1992-01-27 2002-01-30 Janssen Pharmaceutica Nv Derivados de 1h-benzimidazol substituidos por pirrolo-imidazolilo e imidazopiridinilo utilizados como inibidores de aromatase
CA2132449C (en) 1992-03-31 2002-09-10 Susan E. Barrie 17 - substituted steroids useful in cancer treatment
GB9310635D0 (en) 1993-05-21 1993-07-07 Glaxo Group Ltd Chemical compounds
HUT75871A (en) 1993-09-30 1997-05-28 Yamanouchi Co Azole derivatives and pharmaceutical compositions thereof
WO1996014090A1 (en) 1994-11-07 1996-05-17 Janssen Pharmaceutica N.V. Compositions comprising carbazoles and cyclodextrins
AU6015796A (en) 1995-06-14 1997-01-15 Yamanouchi Pharmaceutical Co., Ltd. Fused imidazole derivatives and medicinal composition thereof
CA2281598A1 (en) 1997-02-21 1998-08-27 Tetsuya Aono Fused ring compounds, process for producing the same and use thereof
ATE264304T1 (de) 1997-10-02 2004-04-15 Daiichi Seiyaku Co Dihydronaphthalinderivate und verfahren zur herstellung derselben
US6573289B1 (en) 1998-04-23 2003-06-03 Takeda Chemical Industries, Ltd. Naphthalene derivatives, their production and use
PE20010781A1 (es) * 1999-10-22 2001-08-08 Takeda Chemical Industries Ltd Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion

Also Published As

Publication number Publication date
HK1056168A1 (en) 2004-02-06
NO20032234D0 (no) 2003-05-16
JP2003201282A (ja) 2003-07-18
EP1681290B9 (de) 2013-06-19
CN1680336A (zh) 2005-10-12
JP2006045239A (ja) 2006-02-16
HUP0400549A2 (hu) 2004-06-28
NZ526387A (en) 2004-02-27
HUP0400549A3 (en) 2004-09-28
BR0115306A (pt) 2004-02-10
PE20020596A1 (es) 2002-08-13
PT1334106E (pt) 2006-08-31
ATE327237T1 (de) 2006-06-15
WO2002040484A3 (en) 2002-09-26
KR20030048156A (ko) 2003-06-18
KR20050105287A (ko) 2005-11-03
EP1681290A2 (de) 2006-07-19
PL362766A1 (en) 2004-11-02
AU2005225035A1 (en) 2005-11-10
CA2429133A1 (en) 2002-05-23
US7141598B2 (en) 2006-11-28
EP1681290A3 (de) 2006-07-26
CN1900079A (zh) 2007-01-24
AU2002214296C1 (en) 2006-04-13
CN1329394C (zh) 2007-08-01
ATE533768T1 (de) 2011-12-15
NO326366B1 (no) 2008-11-17
TWI306099B (en) 2009-02-11
EP1681290B1 (de) 2011-11-16
PL204934B1 (pl) 2010-02-26
AU2005225035B2 (en) 2007-02-22
AU1429602A (en) 2002-05-27
KR100809899B1 (ko) 2008-03-10
CN100572363C (zh) 2009-12-23
HU229408B1 (hu) 2013-12-30
WO2002040484A2 (en) 2002-05-23
AU2002214296B2 (en) 2005-09-29
KR20080002929A (ko) 2008-01-04
ES2260303T3 (es) 2006-11-01
US20040033935A1 (en) 2004-02-19
EP1334106B1 (de) 2006-05-24
JP3753971B2 (ja) 2006-03-08
BR0115306B1 (pt) 2013-12-24
MXPA03004347A (es) 2004-05-04
CA2429133C (en) 2009-08-18
KR100725442B1 (ko) 2007-06-07
DE60119963T2 (de) 2006-10-05
IL155624A0 (en) 2003-11-23
NO20032234L (no) 2003-07-16
CN1474819A (zh) 2004-02-11
SI1334106T1 (sl) 2006-10-31
CY1105423T1 (el) 2010-04-28
AR034854A1 (es) 2004-03-24
IL155624A (en) 2006-12-31
DK1334106T3 (da) 2006-09-18
MY134929A (en) 2008-01-31
EP1334106A2 (de) 2003-08-13
JP4427496B2 (ja) 2010-03-10

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Legal Events

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8364 No opposition during term of opposition