NO318804B1 - Stoffsammensetninger og anvendelse derav. - Google Patents

Stoffsammensetninger og anvendelse derav. Download PDF

Info

Publication number: NO318804B1
Authority: NO; Norway
Prior art keywords: ala; glu; gly; ser; lys
Prior art date: 1993-04-07

Application number

NO19940436A

Other languages

English (en)

Norwegian (no)

Other versions

NO940436L (no

NO940436D0 (no

Inventor

Dennis Edward Danley

Robert Alan Gelfand

Kieran Francis Geoghegan

Yesook Kim

William Joseph Lambert

Hong Qi

Original Assignee

Scios Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-07

Filing date

1994-02-09

Publication date

2005-05-09

1994-02-09 Application filed by Scios Inc filed Critical Scios Inc

1994-02-09 Publication of NO940436D0 publication Critical patent/NO940436D0/no

1994-10-10 Publication of NO940436L publication Critical patent/NO940436L/no

2005-05-09 Publication of NO318804B1 publication Critical patent/NO318804B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 111
239000000126 substance Substances 0.000 title claims description 41
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 281
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 231
241000124008 Mammalia Species 0.000 claims abstract description 26
208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 10
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 203
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 127
235000002639 sodium chloride Nutrition 0.000 claims description 121
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239000000725 suspension Substances 0.000 claims description 98
-1 carboxylate salt Chemical class 0.000 claims description 90
239000007900 aqueous suspension Substances 0.000 claims description 86
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 82
150000001408 amides Chemical class 0.000 claims description 82
238000002360 preparation method Methods 0.000 claims description 76
150000001875 compounds Chemical class 0.000 claims description 68
150000003839 salts Chemical class 0.000 claims description 62
239000002253 acid Substances 0.000 claims description 55
125000003275 alpha amino acid group Chemical group 0.000 claims description 51
239000011780 sodium chloride Substances 0.000 claims description 40
230000002473 insulinotropic effect Effects 0.000 claims description 28
230000002641 glycemic effect Effects 0.000 claims description 25
230000002459 sustained effect Effects 0.000 claims description 25
125000005907 alkyl ester group Chemical group 0.000 claims description 23
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 21
230000004962 physiological condition Effects 0.000 claims description 21
239000003513 alkali Substances 0.000 claims description 20
239000007972 injectable composition Substances 0.000 claims description 20
GQZMPWBZQALKJO-UWVGGRQHSA-N Lys-Gly-Arg Chemical compound [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O GQZMPWBZQALKJO-UWVGGRQHSA-N 0.000 claims description 19
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230000000694 effects Effects 0.000 claims description 12
229910021645 metal ion Inorganic materials 0.000 claims description 12
150000002989 phenols Chemical class 0.000 claims description 12
HGNRJCINZYHNOU-LURJTMIESA-N Lys-Gly Chemical compound NCCCC[C@H](N)C(=O)NCC(O)=O HGNRJCINZYHNOU-LURJTMIESA-N 0.000 claims description 11
108010064235 lysylglycine Proteins 0.000 claims description 11
239000003921 oil Substances 0.000 claims description 11
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229910052725 zinc Inorganic materials 0.000 claims description 11
239000011701 zinc Substances 0.000 claims description 11
NGJOFQZEYQGZMB-KTKZVXAJSA-N (4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NGJOFQZEYQGZMB-KTKZVXAJSA-N 0.000 claims description 10
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 10
229910001868 water Inorganic materials 0.000 claims description 10
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims description 8
239000001632 sodium acetate Substances 0.000 claims description 8
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VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 7
230000009471 action Effects 0.000 claims description 7
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229910052751 metal Inorganic materials 0.000 claims description 7
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NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 6
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
235000019483 Peanut oil Nutrition 0.000 claims description 6
239000000312 peanut oil Substances 0.000 claims description 6
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 6
239000002202 Polyethylene glycol Substances 0.000 claims description 5
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239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 claims description 4
229920000936 Agarose Polymers 0.000 claims description 4
235000019489 Almond oil Nutrition 0.000 claims description 4
241000416162 Astragalus gummifer Species 0.000 claims description 4
229920001661 Chitosan Polymers 0.000 claims description 4
229920002907 Guar gum Polymers 0.000 claims description 4
229920000084 Gum arabic Polymers 0.000 claims description 4
229920000569 Gum karaya Polymers 0.000 claims description 4
239000004952 Polyamide Substances 0.000 claims description 4
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229920001710 Polyorthoester Polymers 0.000 claims description 4
239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
235000019485 Safflower oil Nutrition 0.000 claims description 4
229920002472 Starch Polymers 0.000 claims description 4
241000934878 Sterculia Species 0.000 claims description 4
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235000010489 acacia gum Nutrition 0.000 claims description 4
235000010443 alginic acid Nutrition 0.000 claims description 4
239000000783 alginic acid Substances 0.000 claims description 4
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150000004781 alginic acids Chemical class 0.000 claims description 4
239000008168 almond oil Substances 0.000 claims description 4
239000011575 calcium Substances 0.000 claims description 4
239000010495 camellia oil Substances 0.000 claims description 4
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239000004359 castor oil Substances 0.000 claims description 4
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239000003240 coconut oil Substances 0.000 claims description 4
235000019864 coconut oil Nutrition 0.000 claims description 4
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235000012343 cottonseed oil Nutrition 0.000 claims description 4
239000002385 cottonseed oil Substances 0.000 claims description 4
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235000014113 dietary fatty acids Nutrition 0.000 claims description 4
239000000194 fatty acid Substances 0.000 claims description 4
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150000004665 fatty acids Chemical class 0.000 claims description 4
150000002191 fatty alcohols Chemical class 0.000 claims description 4
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
235000010417 guar gum Nutrition 0.000 claims description 4
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KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 4
239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 4
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UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims description 3
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims description 3
239000005695 Ammonium acetate Substances 0.000 claims description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
229920000881 Modified starch Polymers 0.000 claims description 3
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
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235000019257 ammonium acetate Nutrition 0.000 claims description 3
229940043376 ammonium acetate Drugs 0.000 claims description 3
235000019270 ammonium chloride Nutrition 0.000 claims description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical group N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
235000011130 ammonium sulphate Nutrition 0.000 claims description 3
239000001110 calcium chloride Substances 0.000 claims description 3
229910001628 calcium chloride Inorganic materials 0.000 claims description 3
235000011148 calcium chloride Nutrition 0.000 claims description 3
239000011777 magnesium Substances 0.000 claims description 3
229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
235000019341 magnesium sulphate Nutrition 0.000 claims description 3
235000019426 modified starch Nutrition 0.000 claims description 3
239000001103 potassium chloride Substances 0.000 claims description 3
235000011164 potassium chloride Nutrition 0.000 claims description 3
229910000160 potassium phosphate Inorganic materials 0.000 claims description 3
235000011009 potassium phosphates Nutrition 0.000 claims description 3
239000001488 sodium phosphate Substances 0.000 claims description 3
229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
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235000011152 sodium sulphate Nutrition 0.000 claims description 3
239000000375 suspending agent Substances 0.000 claims description 3
YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 claims description 3
239000004280 Sodium formate Substances 0.000 claims description 2
INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 claims description 2
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NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 claims description 2
235000019254 sodium formate Nutrition 0.000 claims description 2
235000011008 sodium phosphates Nutrition 0.000 claims description 2
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 claims description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 claims 1
101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 abstract description 39
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LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 133
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RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 70
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YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 46
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QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Optical Communication System (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO19940436A 1993-04-07 1994-02-09 Stoffsammensetninger og anvendelse derav. NO318804B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4413393A	1993-04-07	1993-04-07

Publications (3)

Publication Number	Publication Date
NO940436D0 NO940436D0 (no)	1994-02-09
NO940436L NO940436L (no)	1994-10-10
NO318804B1 true NO318804B1 (no)	2005-05-09

Family

ID=21930680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19940436A NO318804B1 (no)	1993-04-07	1994-02-09	Stoffsammensetninger og anvendelse derav.

Country Status (18)

Country	Link
EP (1)	EP0619322B1 (zh)
JP (5)	JPH072695A (zh)
KR (1)	KR100186885B1 (zh)
CN (2)	CN1311865C (zh)
AT (1)	ATE314393T1 (zh)
AU (1)	AU682328B2 (zh)
BR (1)	BR9401185A (zh)
CA (1)	CA2116478C (zh)
CZ (1)	CZ296341B6 (zh)
DE (1)	DE69434588T2 (zh)
ES (1)	ES2255051T3 (zh)
HU (1)	HU225496B1 (zh)
IL (1)	IL108611A (zh)
NO (1)	NO318804B1 (zh)
NZ (1)	NZ250844A (zh)
PL (1)	PL180697B1 (zh)
RU (1)	RU2126264C1 (zh)
ZA (1)	ZA94878B (zh)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
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1994
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- 1994-02-09 CZ CZ0027594A patent/CZ296341B6/cs not_active IP Right Cessation
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- 1994-03-02 KR KR1019940003923A patent/KR100186885B1/ko not_active Expired - Lifetime
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CN1544084A (zh)	2004-11-10
IL108611A0 (en)	1994-05-30
HU225496B1 (en)	2007-01-29
AU5501694A (en)	1994-10-13
JP4610503B2 (ja)	2011-01-12
DE69434588D1 (de)	2006-02-02
CZ27594A3 (en)	1995-05-17
CN1080123C (zh)	2002-03-06
ZA94878B (en)	1995-08-10
BR9401185A (pt)	1994-10-18
EP0619322A2 (en)	1994-10-12
CN1311865C (zh)	2007-04-25
NO940436L (no)	1994-10-10
CZ296341B6 (cs)	2006-02-15
NO940436D0 (no)	1994-02-09
JPH072695A (ja)	1995-01-06
JP2001158749A (ja)	2001-06-12
KR100186885B1 (ko)	1999-05-01
JP2004099621A (ja)	2004-04-02
CN1106698A (zh)	1995-08-16
AU682328B2 (en)	1997-10-02
ES2255051T3 (es)	2006-06-16
IL108611A (en)	2004-06-20
CA2116478A1 (en)	1994-10-08
EP0619322A3 (en)	1996-03-13
DE69434588T2 (de)	2006-09-07
JP2006213727A (ja)	2006-08-17
RU2126264C1 (ru)	1999-02-20
HUT68525A (en)	1995-06-28
HK1070589A1 (zh)	2005-06-24
HU9400350D0 (en)	1994-05-30
NZ250844A (en)	1996-03-26
ATE314393T1 (de)	2006-01-15
EP0619322B1 (en)	2005-12-28
JP2010006841A (ja)	2010-01-14
PL180697B1 (pl)	2001-03-30
CA2116478C (en)	2002-12-03
JP5081213B2 (ja)	2012-11-28

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JP2009527526A (ja)	2009-07-30	単鎖インスリンのアナログとその製薬的製剤
WO2003035099A1 (en)	2003-05-01	Biphasic mixtures of glp-1 and insulin
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US20140004198A1 (en)	2014-01-02	Glp-1 particles and compositions
JP6995284B2 (ja)	2022-01-14	新規インスリン類似体およびそれらの使用
JP2014502984A (ja)	2014-02-06	Ｇｌｐ−１組成物
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EP1942115A1 (en)	2008-07-09	Agglutinable glp-1 analogue and sustained-release pharmaceutical composition
HK1070589B (zh)	2007-08-10	肽的延長釋放
AU711428B2 (en)	1999-10-14	Monomeric insulin analog formulations
AU738101B2 (en)	2001-09-06	Monomeric insulin analog formulations
CA2275446A1 (en)	1998-07-02	Protein crystals, their preparation and use
AU2002330064A1 (en)	2003-05-06	Biphasic mixtures of GLP-1 and insulin

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