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NO20083737L - Hydroksysubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler - Google Patents

Hydroksysubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler

Info

Publication number
NO20083737L
NO20083737L NO20083737A NO20083737A NO20083737L NO 20083737 L NO20083737 L NO 20083737L NO 20083737 A NO20083737 A NO 20083737A NO 20083737 A NO20083737 A NO 20083737A NO 20083737 L NO20083737 L NO 20083737L
Authority
NO
Norway
Prior art keywords
substituted
hydroxy
hypocholesterolemic agents
azetidinones useful
cholesterol
Prior art date
Application number
NO20083737A
Other languages
English (en)
Inventor
Harry R Davis
James E Patrick
Anima Ghosal
Shmuel Zbaida
Swapan K Chowdhury
Robert M Iannucci
Wenqing Feng
Kevin B Alton
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083737(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO20083737L publication Critical patent/NO20083737L/no
Application filed by Schering Corp filed Critical Schering Corp

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hypokolesterolemiske sukkersubstitu-erte 2-azetidinon-forbindelser og fremgangsmåte for å senke kolesterol ved å administrere forbindelsen, farmasøytiske preparater som inneholder den og kombinasjonen av et sukkersubstituert kolesterolsenkende 2-azetidinon og en kolesterolbiosynteseinhibitor for behandling og forhindring av aterosklerose.
NO20083737A 2000-12-20 2008-08-29 Hydroksysubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler NO20083737L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20
PCT/US2001/049127 WO2002050090A1 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
NO20083737L true NO20083737L (no) 2003-08-19

Family

ID=22973953

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20032806A NO326981B1 (no) 2000-12-20 2003-06-19 Sukkersubstituerte 2-azetidinoner anvendelige som hypokolesterolemiske midler, farmasoytisk preparat og anvendelse av forbindelsene for fremstilling av et medikament
NO20083737A NO20083737L (no) 2000-12-20 2008-08-29 Hydroksysubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20032806A NO326981B1 (no) 2000-12-20 2003-06-19 Sukkersubstituerte 2-azetidinoner anvendelige som hypokolesterolemiske midler, farmasoytisk preparat og anvendelse av forbindelsene for fremstilling av et medikament

Country Status (34)

Country Link
US (1) US20020137690A1 (no)
EP (1) EP1347987B1 (no)
JP (2) JP4351842B2 (no)
KR (1) KR100883461B1 (no)
CN (1) CN100475829C (no)
AR (1) AR035611A1 (no)
AT (2) ATE279425T1 (no)
AU (2) AU2002231049B2 (no)
BR (1) BR0116212A (no)
CA (1) CA2432798C (no)
CY (1) CY1106912T1 (no)
CZ (1) CZ302193B6 (no)
DE (2) DE60129863T2 (no)
DK (2) DK1347987T3 (no)
EC (1) ECSP034659A (no)
ES (2) ES2287826T3 (no)
GE (1) GEP20053548B (no)
HU (1) HUP0302269A3 (no)
IL (1) IL155771A0 (no)
MA (1) MA26975A1 (no)
MX (1) MXPA03005671A (no)
MY (1) MY129148A (no)
NO (2) NO326981B1 (no)
NZ (1) NZ525722A (no)
PE (1) PE20020718A1 (no)
PL (1) PL208242B1 (no)
PT (2) PT1593670E (no)
RU (1) RU2297422C2 (no)
SI (2) SI1347987T1 (no)
SK (1) SK286703B6 (no)
TR (1) TR200402758T4 (no)
TW (1) TWI316942B (no)
WO (1) WO2002050090A1 (no)
ZA (1) ZA200303694B (no)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
RS50406B (sr) 2001-01-26 2009-12-31 Schering Corporation, Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
UA75644C2 (en) 2001-03-28 2006-05-15 Schering Corp Enantioselective synthesis of azetidinone intermediate compounds
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
EP1562582A1 (en) 2002-11-06 2005-08-17 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
ES2311806T3 (es) 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2005015434A (ja) 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
ATE485267T1 (de) * 2003-12-23 2010-11-15 Astrazeneca Ab Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
JP2007516287A (ja) 2003-12-23 2007-06-21 メルク　エンド　カムパニー　インコーポレーテッド 抗高コレステロール血症化合物
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
MX2007003732A (es) * 2004-09-29 2007-04-23 Schering Corp Combinaciones de azetidononas sustituidas y antagonistas de receptor de canabinoide 1.
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008136765A (ru) * 2006-03-06 2010-04-20 Тева Фармасьютикл Индастриес Лтд. (Il) Композиции эзетимиба
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
CN101652377A (zh) * 2007-04-02 2010-02-17 泰拉科斯有限公司 苄基化糖苷衍生物及其用法
WO2010075068A1 (en) 2008-12-16 2010-07-01 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
ES2487540T3 (es) * 2009-02-11 2014-08-21 Dow Agrosciences Llc Composiciones plaguicidas
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
MY114803A (en) * 1995-10-31 2003-01-31 Schering Corp Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
AU3104902A (en) 2002-07-01
CN1483039A (zh) 2004-03-17
DE60129863T2 (de) 2008-04-30
HUP0302269A2 (hu) 2003-10-28
DK1593670T3 (da) 2007-11-05
ECSP034659A (es) 2003-07-25
DK1347987T3 (da) 2005-01-31
KR100883461B1 (ko) 2009-02-16
CA2432798C (en) 2007-02-27
PT1347987E (pt) 2005-01-31
HUP0302269A3 (en) 2009-08-28
WO2002050090A1 (en) 2002-06-27
PL363237A1 (en) 2004-11-15
TWI316942B (en) 2009-11-11
GEP20053548B (en) 2005-06-27
US20020137690A1 (en) 2002-09-26
JP4351842B2 (ja) 2009-10-28
CN100475829C (zh) 2009-04-08
PE20020718A1 (es) 2002-08-09
DE60106489T2 (de) 2005-10-13
SI1593670T1 (sl) 2007-12-31
MY129148A (en) 2007-03-30
ATE279425T1 (de) 2004-10-15
NO20032806D0 (no) 2003-06-19
ES2230385T3 (es) 2005-05-01
RU2297422C2 (ru) 2007-04-20
CZ20031674A3 (cs) 2003-10-15
NO20032806L (no) 2003-08-19
DE60106489D1 (de) 2004-11-18
SI1347987T1 (en) 2005-02-28
IL155771A0 (en) 2003-12-23
MA26975A1 (fr) 2004-12-20
CY1106912T1 (el) 2012-09-26
JP2009132745A (ja) 2009-06-18
HK1084945A1 (en) 2006-08-11
CA2432798A1 (en) 2002-06-27
RU2003122520A (ru) 2005-02-27
JP2004516299A (ja) 2004-06-03
ZA200303694B (en) 2004-08-13
SK7702003A3 (en) 2003-10-07
BR0116212A (pt) 2003-12-30
KR20030063414A (ko) 2003-07-28
PT1593670E (pt) 2007-11-08
WO2002050090A8 (en) 2004-04-15
PL208242B1 (pl) 2011-04-29
DE60129863D1 (de) 2007-09-20
MXPA03005671A (es) 2003-10-06
CZ302193B6 (cs) 2010-12-08
AR035611A1 (es) 2004-06-16
SK286703B6 (sk) 2009-03-05
ATE369334T1 (de) 2007-08-15
TR200402758T4 (tr) 2004-11-22
EP1347987A1 (en) 2003-10-01
NO326981B1 (no) 2009-03-30
NZ525722A (en) 2004-11-26
ES2287826T3 (es) 2007-12-16
EP1347987B1 (en) 2004-10-13
AU2002231049B2 (en) 2006-07-20
HK1056735A1 (en) 2004-02-27

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