MA26975A1 - 2-azetinones substituees par des sucres utilisees comme agents hypocholesterolemiants - Google Patents

2-azetinones substituees par des sucres utilisees comme agents hypocholesterolemiants

Info

Publication number: MA26975A1
Authority: MA; Morocco
Prior art keywords: substituted; azetinones; hypocholesterolemizing; agents; cholesterol
Prior art date: 2000-12-20

Application number

MA27205A

Other languages

English (en)

Inventor

Anima Ghosal

Shmuel Zbaida

Swapan K Chowdhury

Robert M Iannucci

Wenqing Feng

Kevin B Alton

James E Patrick

Harry R Davis

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-20

Filing date

2003-06-19

Publication date

2004-12-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA26975(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-06-19 Application filed by Schering Corp filed Critical Schering Corp

2004-12-20 Publication of MA26975A1 publication Critical patent/MA26975A1/fr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MA27205A 2000-12-20 2003-06-19 2-azetinones substituees par des sucres utilisees comme agents hypocholesterolemiants MA26975A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25687500P	2000-12-20	2000-12-20

Publications (1)

Publication Number	Publication Date
MA26975A1 true MA26975A1 (fr)	2004-12-20

Family

ID=22973953

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA27205A MA26975A1 (fr)	2000-12-20	2003-06-19	2-azetinones substituees par des sucres utilisees comme agents hypocholesterolemiants

Country Status (34)

Country	Link
US (1)	US20020137690A1 (fr)
EP (1)	EP1347987B1 (fr)
JP (2)	JP4351842B2 (fr)
KR (1)	KR100883461B1 (fr)
CN (1)	CN100475829C (fr)
AR (1)	AR035611A1 (fr)
AT (2)	ATE279425T1 (fr)
AU (2)	AU2002231049B2 (fr)
BR (1)	BR0116212A (fr)
CA (1)	CA2432798C (fr)
CY (1)	CY1106912T1 (fr)
CZ (1)	CZ302193B6 (fr)
DE (2)	DE60129863T2 (fr)
DK (2)	DK1347987T3 (fr)
EC (1)	ECSP034659A (fr)
ES (2)	ES2287826T3 (fr)
GE (1)	GEP20053548B (fr)
HU (1)	HUP0302269A3 (fr)
IL (1)	IL155771A0 (fr)
MA (1)	MA26975A1 (fr)
MX (1)	MXPA03005671A (fr)
MY (1)	MY129148A (fr)
NO (2)	NO326981B1 (fr)
NZ (1)	NZ525722A (fr)
PE (1)	PE20020718A1 (fr)
PL (1)	PL208242B1 (fr)
PT (2)	PT1593670E (fr)
RU (1)	RU2297422C2 (fr)
SI (2)	SI1347987T1 (fr)
SK (1)	SK286703B6 (fr)
TR (1)	TR200402758T4 (fr)
TW (1)	TWI316942B (fr)
WO (1)	WO2002050090A1 (fr)
ZA (1)	ZA200303694B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl)	2001-01-26	2008-02-29	Schering Corp	Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
RS50406B (sr)	2001-01-26	2009-12-31	Schering Corporation,	Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
UA75644C2 (en)	2001-03-28	2006-05-15	Schering Corp	Enantioselective synthesis of azetidinone intermediate compounds
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es)	2001-09-21	2004-06-18	Schering Corp	Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
EP1562582A1 (fr)	2002-11-06	2005-08-17	Schering Corporation	Inhibiteurs d'absorption du cholesterol pour le traitement de la demyelination
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
ES2311806T3 (es)	2003-03-07	2009-02-16	Schering Corporation	Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7192944B2 (en)	2003-03-07	2007-03-20	Schering Corp.	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2005015434A (ja)	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (fr) *	2003-10-07	2005-04-13	Lipideon Biotechnology AG	Nouveaux composés hypocholesterolémiques
EP1918000A2 (fr)	2003-11-05	2008-05-07	Schering Corporation	Combinaisons d'agents de modulation lipide et azétidinones substitués et traitements pour conditions vasculaires
ATE485267T1 (de) *	2003-12-23	2010-11-15	Astrazeneca Ab	Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
JP2007516287A (ja)	2003-12-23	2007-06-21	メルク　エンド　カムパニー　インコーポレーテッド	抗高コレステロール血症化合物
GB0329778D0 (en) *	2003-12-23	2004-01-28	Astrazeneca Ab	Chemical compounds
MX2007003732A (es) *	2004-09-29	2007-04-23	Schering Corp	Combinaciones de azetidononas sustituidas y antagonistas de receptor de canabinoide 1.
US7737155B2 (en)	2005-05-17	2010-06-15	Schering Corporation	Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) *	2005-06-22	2007-06-27	Astrazeneca Ab	Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008136765A (ru) *	2006-03-06	2010-04-20	Тева Фармасьютикл Индастриес Лтд. (Il)	Композиции эзетимиба
AR060623A1 (es)	2006-04-27	2008-07-02	Astrazeneca Ab	Compuestos derivados de 2-azetidinona y un metodo de preparacion
CN101652377A (zh) *	2007-04-02	2010-02-17	泰拉科斯有限公司	苄基化糖苷衍生物及其用法
WO2010075068A1 (fr)	2008-12-16	2010-07-01	Schering Corporation	Dérivés de pyridopyrimidine et leurs procédés d'utilisation
EP2379562A1 (fr)	2008-12-16	2011-10-26	Schering Corporation	Dérivés de pyranone bicyclique comme agonistes du récepteur de l'acide nicotinique
ES2487540T3 (es) *	2009-02-11	2014-08-21	Dow Agrosciences Llc	Composiciones plaguicidas
WO2010100255A1 (fr)	2009-03-06	2010-09-10	Lipideon Biotechnology Ag	Compositions pharmaceutiques hypocholestérolémiques
EP2414529A2 (fr)	2009-04-01	2012-02-08	Matrix Laboratories Ltd	Procédé enzymatique pour la préparation de la (s)-5-(4-fluorophényl)-5-hydroxy-1-morpholin-4-yl-pentan-1-one, un intermédiaire de l'ézétimibe et la conversion ultérieure en ézétimibe
CN101993403B (zh)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) *	2009-11-30	2012-01-05	최길용	곱셈 학습기
KR20150079373A (ko)	2013-12-30	2015-07-08	한미약품 주식회사	에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) *	2015-08-19	2017-07-18	四川大学	Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3595B (en) *	1993-01-21	1995-12-27	Schering Corp	Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) *	1994-03-25	1997-05-06	Schering Corporation	Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) *	1994-11-18	1997-05-27	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
MY114803A (en) *	1995-10-31	2003-01-31	Schering Corp	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US5756470A (en) *	1996-10-29	1998-05-26	Schering Corporation	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) *	1999-10-14	1999-11-04	University Of Melbourne, The	Conjugates and uses thereof

2001
- 2001-12-17 CZ CZ20031674A patent/CZ302193B6/cs not_active IP Right Cessation
- 2001-12-17 CA CA002432798A patent/CA2432798C/fr not_active Expired - Fee Related
- 2001-12-17 SI SI200130228T patent/SI1347987T1/xx unknown
- 2001-12-17 ES ES05004699T patent/ES2287826T3/es not_active Expired - Lifetime
- 2001-12-17 SK SK770-2003A patent/SK286703B6/sk not_active IP Right Cessation
- 2001-12-17 EP EP01991315A patent/EP1347987B1/fr not_active Expired - Lifetime
- 2001-12-17 BR BR0116212-8A patent/BR0116212A/pt active Search and Examination
- 2001-12-17 WO PCT/US2001/049127 patent/WO2002050090A1/fr not_active Ceased
- 2001-12-17 DK DK01991315T patent/DK1347987T3/da active
- 2001-12-17 PL PL363237A patent/PL208242B1/pl not_active IP Right Cessation
- 2001-12-17 PT PT05004699T patent/PT1593670E/pt unknown
- 2001-12-17 DE DE60129863T patent/DE60129863T2/de not_active Expired - Lifetime
- 2001-12-17 AT AT01991315T patent/ATE279425T1/de active
- 2001-12-17 KR KR1020037007778A patent/KR100883461B1/ko not_active Expired - Fee Related
- 2001-12-17 AU AU2002231049A patent/AU2002231049B2/en not_active Ceased
- 2001-12-17 AR ARP010105837A patent/AR035611A1/es not_active Application Discontinuation
- 2001-12-17 NZ NZ525722A patent/NZ525722A/en not_active IP Right Cessation
- 2001-12-17 AT AT05004699T patent/ATE369334T1/de active
- 2001-12-17 US US10/023,295 patent/US20020137690A1/en not_active Abandoned
- 2001-12-17 HU HU0302269A patent/HUP0302269A3/hu unknown
- 2001-12-17 RU RU2003122520/04A patent/RU2297422C2/ru not_active IP Right Cessation
- 2001-12-17 AU AU3104902A patent/AU3104902A/xx active Pending
- 2001-12-17 PT PT01991315T patent/PT1347987E/pt unknown
- 2001-12-17 MX MXPA03005671A patent/MXPA03005671A/es active IP Right Grant
- 2001-12-17 PE PE2001001260A patent/PE20020718A1/es not_active Application Discontinuation
- 2001-12-17 TR TR2004/02758T patent/TR200402758T4/xx unknown
- 2001-12-17 CN CNB01821133XA patent/CN100475829C/zh not_active Expired - Fee Related
- 2001-12-17 DK DK05004699T patent/DK1593670T3/da active
- 2001-12-17 ES ES01991315T patent/ES2230385T3/es not_active Expired - Lifetime
- 2001-12-17 JP JP2002551983A patent/JP4351842B2/ja not_active Expired - Fee Related
- 2001-12-17 IL IL15577101A patent/IL155771A0/xx not_active IP Right Cessation
- 2001-12-17 SI SI200130760T patent/SI1593670T1/sl unknown
- 2001-12-17 DE DE60106489T patent/DE60106489T2/de not_active Expired - Lifetime
- 2001-12-18 TW TW090131349A patent/TWI316942B/zh not_active IP Right Cessation
- 2001-12-19 MY MYPI20015742A patent/MY129148A/en unknown
2003
- 2003-05-13 ZA ZA200303694A patent/ZA200303694B/en unknown
- 2003-06-19 NO NO20032806A patent/NO326981B1/no not_active IP Right Cessation
- 2003-06-19 MA MA27205A patent/MA26975A1/fr unknown
- 2003-06-19 EC EC2003004659A patent/ECSP034659A/es unknown
2004
- 2004-11-19 GE GEAP8505A patent/GEP20053548B/en unknown
2007
- 2007-10-08 CY CY20071101279T patent/CY1106912T1/el unknown
2008
- 2008-08-29 NO NO20083737A patent/NO20083737L/no not_active Application Discontinuation
2009
- 2009-03-25 JP JP2009075266A patent/JP2009132745A/ja active Pending

Also Published As

Publication number	Publication date
AU3104902A (en)	2002-07-01
CN1483039A (zh)	2004-03-17
DE60129863T2 (de)	2008-04-30
HUP0302269A2 (hu)	2003-10-28
DK1593670T3 (da)	2007-11-05
ECSP034659A (es)	2003-07-25
DK1347987T3 (da)	2005-01-31
KR100883461B1 (ko)	2009-02-16
CA2432798C (fr)	2007-02-27
PT1347987E (pt)	2005-01-31
HUP0302269A3 (en)	2009-08-28
WO2002050090A1 (fr)	2002-06-27
PL363237A1 (en)	2004-11-15
TWI316942B (en)	2009-11-11
GEP20053548B (en)	2005-06-27
US20020137690A1 (en)	2002-09-26
JP4351842B2 (ja)	2009-10-28
CN100475829C (zh)	2009-04-08
PE20020718A1 (es)	2002-08-09
DE60106489T2 (de)	2005-10-13
SI1593670T1 (sl)	2007-12-31
MY129148A (en)	2007-03-30
ATE279425T1 (de)	2004-10-15
NO20032806D0 (no)	2003-06-19
ES2230385T3 (es)	2005-05-01
RU2297422C2 (ru)	2007-04-20
CZ20031674A3 (cs)	2003-10-15
NO20032806L (no)	2003-08-19
DE60106489D1 (de)	2004-11-18
SI1347987T1 (en)	2005-02-28
IL155771A0 (en)	2003-12-23
CY1106912T1 (el)	2012-09-26
JP2009132745A (ja)	2009-06-18
HK1084945A1 (en)	2006-08-11
CA2432798A1 (fr)	2002-06-27
RU2003122520A (ru)	2005-02-27
JP2004516299A (ja)	2004-06-03
NO20083737L (no)	2003-08-19
ZA200303694B (en)	2004-08-13
SK7702003A3 (en)	2003-10-07
BR0116212A (pt)	2003-12-30
KR20030063414A (ko)	2003-07-28
PT1593670E (pt)	2007-11-08
WO2002050090A8 (fr)	2004-04-15
PL208242B1 (pl)	2011-04-29
DE60129863D1 (de)	2007-09-20
MXPA03005671A (es)	2003-10-06
CZ302193B6 (cs)	2010-12-08
AR035611A1 (es)	2004-06-16
SK286703B6 (sk)	2009-03-05
ATE369334T1 (de)	2007-08-15
TR200402758T4 (tr)	2004-11-22
EP1347987A1 (fr)	2003-10-01
NO326981B1 (no)	2009-03-30
NZ525722A (en)	2004-11-26
ES2287826T3 (es)	2007-12-16
EP1347987B1 (fr)	2004-10-13
AU2002231049B2 (en)	2006-07-20
HK1056735A1 (en)	2004-02-27

Publication	Publication Date	Title
MA26975A1 (fr)	2004-12-20	2-azetinones substituees par des sucres utilisees comme agents hypocholesterolemiants
MY114803A (en)	2003-01-31	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
PL369108A1 (en)	2005-04-18	17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
WO2001081310A8 (fr)	2002-02-07	1-aroyle-piperidinyle benzamidines
CY1110361T1 (el)	2015-04-29	Φαρμακευτικες συνθεσεις ως αναστολεις διπεπτιδυλικης πεπτιδασης iv (dpp-iv)
ECSP045104A (es)	2004-06-28	Ligandos de los receptores de los cannabinoides
DK1499590T3 (da)	2006-07-31	Piperidinderivater som kaliumkanalblokkere
WO2005005389A3 (fr)	2005-03-24	Derives de malonamide
HRP20090159T1 (en)	2009-05-31	Use of glucosidase inhibitors for therapy of mucovisidosis
WO2004043456A8 (fr)	2004-07-22	Inhibiteurs d'absorption du cholesterol pour le traitement de la demyelination
WO2002042271A3 (fr)	2002-11-21	Biphenylcarboxamides utiles comme hypolipidemiants
NO20054787L (no)	2005-11-14	Indenderivater som farmasotiske midler
JO2390B1 (en)	2007-06-17	Diphenylcarboxamides act as lipid-lowering agents
MXPA05001712A (es)	2005-04-19	Bifenilcarboxamidas sustituidas con n-aril piperidina como inhibidores de la secrecion de apolipoproteina b.
AUPR118000A0 (en)	2000-11-23	Therapeutic molecules and methods
MXPA04000324A (es)	2004-07-23	Una combinacion farmaceutica sinergistica para la prevencion o tratamiento de diabetes.
AU2003300385A1 (en)	2004-05-04	Anticancer compounds
ATE308540T1 (de)	2005-11-15	Antithrombosemittel
AU2002339158A1 (en)	2003-06-10	2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
AU2001282238A1 (en)	2002-02-13	Dihydroporphyrin derivatives and their uses
PL365517A1 (en)	2005-01-10	Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence
DE602004011064D1 (en)	2008-02-14	Antitrombotische aether
TW200640464A (en)	2006-12-01	Pharmaceutical composition comprising phenoxazinium compounds as an active ingredient
EP1626044A4 (fr)	2008-08-20	Nouveau derive de piperidine
WO2003090737A3 (fr)	2004-04-01	Methodes et compositions de traitement de la douleur cancereuse