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MA30006B1 - Composes anti-hypercholesterolemiques - Google Patents

Composes anti-hypercholesterolemiques

Info

Publication number
MA30006B1
MA30006B1 MA30894A MA30894A MA30006B1 MA 30006 B1 MA30006 B1 MA 30006B1 MA 30894 A MA30894 A MA 30894A MA 30894 A MA30894 A MA 30894A MA 30006 B1 MA30006 B1 MA 30006B1
Authority
MA
Morocco
Prior art keywords
compounds
cholesterol
hypercholesterolemic compounds
hypercholesterolemic
esters
Prior art date
Application number
MA30894A
Other languages
English (en)
Inventor
Robert J Devita
Gregori J Morriello
Peter Lin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA30006B1 publication Critical patent/MA30006B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention fournit des inhibiteurs de l'absorption du cholestérol de formule 1 et les sels pharmaceutiquement acceptables et esters de ceux-là. Les composés sont utiles pour abaisser les niveaux du cholestérol plasmatique, en particulier le LDL-cholestérol, et pour le traitement et la prévention de l'athérosclérose et des événements de la maladie athéroscléreuse.
MA30894A 2005-10-05 2008-05-02 Composes anti-hypercholesterolemiques MA30006B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72378105P 2005-10-05 2005-10-05

Publications (1)

Publication Number Publication Date
MA30006B1 true MA30006B1 (fr) 2008-12-01

Family

ID=37845278

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30894A MA30006B1 (fr) 2005-10-05 2008-05-02 Composes anti-hypercholesterolemiques

Country Status (25)

Country Link
US (2) US20090137546A1 (fr)
EP (1) EP1934175B1 (fr)
JP (1) JP4879991B2 (fr)
KR (1) KR20080050610A (fr)
CN (1) CN101277930A (fr)
AR (1) AR058068A1 (fr)
AT (1) ATE488495T1 (fr)
AU (1) AU2006302584B2 (fr)
BR (1) BRPI0616834A2 (fr)
CA (1) CA2624481C (fr)
CR (1) CR9903A (fr)
DE (1) DE602006018341D1 (fr)
DO (1) DOP2006000211A (fr)
EA (1) EA200801008A1 (fr)
ES (1) ES2354460T3 (fr)
GT (1) GT200600444A (fr)
IL (1) IL190434A0 (fr)
MA (1) MA30006B1 (fr)
NO (1) NO20082075L (fr)
PE (1) PE20070493A1 (fr)
SV (1) SV2009002863A (fr)
TN (1) TNSN08153A1 (fr)
TW (1) TW200806623A (fr)
WO (1) WO2007044318A2 (fr)
ZA (1) ZA200802587B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7871998B2 (en) * 2003-12-23 2011-01-18 Astrazeneca Ab Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity
CN100471835C (zh) * 2003-12-23 2009-03-25 默克公司 抗高胆固醇血症化合物
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
UY29607A1 (es) * 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR057380A1 (es) * 2005-06-22 2007-11-28 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos
AR057383A1 (es) * 2005-06-22 2007-12-05 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
MY148538A (en) * 2005-06-22 2013-04-30 Astrazeneca Ab Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AR060623A1 (es) * 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
WO2008085300A1 (fr) * 2006-12-20 2008-07-17 Merck & Co., Inc. Composé anti-hypercholestérolémique
US8029405B2 (en) 2008-05-30 2011-10-04 Hyundai Motor Company Gear train of automatic transmission for vehicles
WO2010056788A1 (fr) * 2008-11-17 2010-05-20 Merck Sharp & Dohme Corp. Composés anti-hypercholestérolémiques

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102582A0 (en) * 1991-07-23 1993-01-14 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AU2943095A (en) * 1994-06-20 1996-01-15 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
KR100833089B1 (ko) * 2000-12-21 2008-05-29 사노피-아벤티스 도이칠란트 게엠베하 신규한 1,2-디페닐아제티딘온 및 당해 화합물을 함유하는 지질 대사 장애를 치료하기 위한 약제학적 조성물
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
CA2517571C (fr) * 2003-03-07 2011-07-05 Schering Corporation Azetidinones substituees , procedes pour leur preparation, formulations et utilisations de celles-ci
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
CN100471835C (zh) * 2003-12-23 2009-03-25 默克公司 抗高胆固醇血症化合物
EP1851197A2 (fr) * 2005-02-09 2007-11-07 Microbia, Inc. Derives de phenylazetidinone
CA2611142A1 (fr) * 2005-06-15 2006-12-28 Merck & Co., Inc. Composes anti-hypercholesterolemiques
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AU2007315327A1 (en) * 2006-11-02 2008-05-08 Sanofi-Aventis Deutschland Gmbh Novel diphenylazetidinone substituted by piperazine-1-sulfonic acid having improved pharmacological properties

Also Published As

Publication number Publication date
ES2354460T3 (es) 2011-03-15
SV2009002863A (es) 2009-02-19
EP1934175B1 (fr) 2010-11-17
AU2006302584B2 (en) 2011-10-13
WO2007044318A3 (fr) 2007-07-12
JP2009511475A (ja) 2009-03-19
EA200801008A1 (ru) 2009-02-27
JP4879991B2 (ja) 2012-02-22
CA2624481C (fr) 2012-04-03
GT200600444A (es) 2007-05-04
AR058068A1 (es) 2008-01-23
ATE488495T1 (de) 2010-12-15
US7704988B2 (en) 2010-04-27
TW200806623A (en) 2008-02-01
CR9903A (es) 2008-07-29
DOP2006000211A (es) 2007-05-31
DE602006018341D1 (de) 2010-12-30
IL190434A0 (en) 2008-11-03
CN101277930A (zh) 2008-10-01
BRPI0616834A2 (pt) 2016-08-23
NO20082075L (no) 2008-07-04
PE20070493A1 (es) 2007-06-13
TNSN08153A1 (en) 2009-10-30
US20090137546A1 (en) 2009-05-28
US20070078098A1 (en) 2007-04-05
ZA200802587B (en) 2009-06-24
AU2006302584A1 (en) 2007-04-19
KR20080050610A (ko) 2008-06-09
CA2624481A1 (fr) 2007-04-19
EP1934175A2 (fr) 2008-06-25
WO2007044318A2 (fr) 2007-04-19

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