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NO20081892L - Polycykliske karbamoylpyridonderivat med HIV-integraseinhiberende aktivitet - Google Patents

Polycykliske karbamoylpyridonderivat med HIV-integraseinhiberende aktivitet

Info

Publication number
NO20081892L
NO20081892L NO20081892A NO20081892A NO20081892L NO 20081892 L NO20081892 L NO 20081892L NO 20081892 A NO20081892 A NO 20081892A NO 20081892 A NO20081892 A NO 20081892A NO 20081892 L NO20081892 L NO 20081892L
Authority
NO
Norway
Prior art keywords
optionally substituted
lower alkyl
heterocyclic group
hydrogen
inhibitory activity
Prior art date
Application number
NO20081892A
Other languages
English (en)
Inventor
Takashi Kawasuji
Teruhiko Taishi
Yoshiyuki Taoda
Hiroshi Yoshida
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37967785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081892(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO20081892L publication Critical patent/NO20081892L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår en ny forbindelse som har en antiviral aktivitet, spesielt en HIV integrasehemmende aktivitet, og et farmasøytisk preparat, spesielt et anti-HIV middel. (hvor R1 er hyd rogen eller lavere alkyl; X er lavere alkylen etc.; R2 er eventuelt substituert aryl; R3 er hydrogen, halogen, hydroksy, eventuelt substituert lavere alkyl etc.; R4 er hydrogen, eventuelt substituert lavere alkyl, eventuelt substituert sykloalkyl, eventuelt substituert sykloalkyl lavere alkyl, eventuelt substituert aryl, eventuelt substituert aryl lavere alkyl, eventuelt substituert heterosyklisk gruppe, eventuelt substituert heterosyklisk lavere alkyl etc.; En brutt linje indikerer nærvær eller fravær av en binding; B1 og B2 er slik at hvilken som helst av dem er CR20R21 og den andre er NR22, og i dette tilfellet er det ingen brutt linje. Når B2 er NR22 kan R4 og R22 være forbundet sammen for å danne en eventuelt substituert heterosyklisk gruppe; Når B2 er CHR21 kan R4 og R21 være forbundet sammen for å danne en eventuelt substituert heterosyklisk gruppe. Alternativt er B1 og B2 uavhengig C, CR23 eller N, og i dette tilfellet kan B1 og B2 sammen danne en heterosyklisk gruppe. R20, R21, R22 og R23 er uavhengig hydrogen, eventuelt substituert lavere alkyl, eventuelt substituert sykloalkyl, eventuelt substituert sykloalkyl lavere alkyl etc.
NO20081892A 2005-10-27 2008-04-22 Polycykliske karbamoylpyridonderivat med HIV-integraseinhiberende aktivitet NO20081892L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005312076 2005-10-27
JP2006223875 2006-08-21
PCT/JP2006/321335 WO2007049675A1 (ja) 2005-10-27 2006-10-26 Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体

Publications (1)

Publication Number Publication Date
NO20081892L true NO20081892L (no) 2008-06-23

Family

ID=37967785

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081892A NO20081892L (no) 2005-10-27 2008-04-22 Polycykliske karbamoylpyridonderivat med HIV-integraseinhiberende aktivitet

Country Status (15)

Country Link
US (2) US8188271B2 (no)
EP (1) EP1950212B1 (no)
JP (1) JP5131689B2 (no)
KR (1) KR20080064182A (no)
AU (1) AU2006307101A1 (no)
BR (1) BRPI0617842A2 (no)
CA (1) CA2626956A1 (no)
EA (1) EA200801144A1 (no)
ES (1) ES2569357T3 (no)
IL (1) IL190879A0 (no)
MA (1) MA29879B1 (no)
MX (1) MX2008005137A (no)
NO (1) NO20081892L (no)
TW (1) TW200800988A (no)
WO (1) WO2007049675A1 (no)

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EP1950212A4 (en) 2010-08-04
WO2007049675A1 (ja) 2007-05-03
BRPI0617842A2 (pt) 2011-08-09
MA29879B1 (fr) 2008-10-03
EP1950212A1 (en) 2008-07-30
US20120208998A1 (en) 2012-08-16
KR20080064182A (ko) 2008-07-08
MX2008005137A (es) 2008-09-29
IL190879A0 (en) 2008-11-03
JPWO2007049675A1 (ja) 2009-04-30
JP5131689B2 (ja) 2013-01-30
TW200800988A (en) 2008-01-01
CA2626956A1 (en) 2007-05-03
EA200801144A1 (ru) 2008-10-30
AU2006307101A1 (en) 2007-05-03
US8188271B2 (en) 2012-05-29
US20090143356A1 (en) 2009-06-04
EP1950212B1 (en) 2016-02-24

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