UA96568C2 - Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor - Google Patents
Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitorInfo
- Publication number
- UA96568C2 UA96568C2 UAA200711345A UAA200711345A UA96568C2 UA 96568 C2 UA96568 C2 UA 96568C2 UA A200711345 A UAA200711345 A UA A200711345A UA A200711345 A UAA200711345 A UA A200711345A UA 96568 C2 UA96568 C2 UA 96568C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hiv
- compound
- ris
- integrase inhibitor
- optionally substituted
- Prior art date
Links
- -1 Polycyclic carbamoyl pyridone derivative Chemical class 0.000 title abstract 3
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 230000002155 anti-virotic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Zis NR; Ris hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SOand NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; Ris optionally substituted aryl; Ris hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and Rand Zpart taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound., (I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005131161 | 2005-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA96568C2 true UA96568C2 (en) | 2011-11-25 |
Family
ID=39612449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200711345A UA96568C2 (en) | 2005-04-28 | 2006-04-28 | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101212903B (en) |
| UA (1) | UA96568C2 (en) |
| ZA (1) | ZA200708970B (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105198804B (en) * | 2008-07-25 | 2018-03-23 | 盐野义制药株式会社 | Compound as hiv integrase inhibitor |
| JP5572168B2 (en) * | 2008-12-11 | 2014-08-13 | ビーブ・ヘルスケア・カンパニー | Process for producing carbamoylpyridone HIV integrase inhibitor and intermediate |
| PT2444400T (en) * | 2009-06-15 | 2018-06-06 | Shionogi & Co | Substituted polycyclic carbamoylpyridone derivative |
| SMT201800290T1 (en) * | 2010-01-27 | 2018-07-17 | Viiv Healthcare Co | Antiviral therapy |
| TWI582097B (en) * | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | Process for preparing carbamoylpyridone derivatives and intermediates |
| PT3456721T (en) * | 2010-08-05 | 2021-05-04 | Shionogi & Co | Method of producing compounds having hiv integrase inhivitory activity |
| KR101773226B1 (en) * | 2010-09-24 | 2017-09-12 | 시오노기세야쿠 가부시키가이샤 | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| AU2014324829B2 (en) * | 2013-09-27 | 2017-09-07 | Merck Sharp & Dohme Corp. | Substituted Quinolizine Derivatives useful as HIV integrase inhibitors |
| NO2717902T3 (en) * | 2014-06-20 | 2018-06-23 | ||
| KR20190057158A (en) * | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| US11091483B2 (en) * | 2016-08-12 | 2021-08-17 | Madera Therapeutics, LLC | Protein kinase regulators |
| CN106565747A (en) * | 2016-11-10 | 2017-04-19 | 顾世海 | Novel method for preparing dolutegravir |
| JOP20190130A1 (en) * | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | Tetracyclic heterocyclic compounds useful as integrated enzyme inhibitors for human immunodeficiency virus (HIV) |
| CN108250215B (en) * | 2016-12-28 | 2022-04-19 | 华创合成制药股份有限公司 | Novel anti-HIV medicine, preparation method and application thereof |
| MX388699B (en) * | 2017-02-16 | 2025-03-20 | Viiv Healthcare Uk No 3 Ltd | Crystalline forms of sodium cabotegravir |
| CN110526930B (en) * | 2018-05-23 | 2022-06-03 | 莫云芬 | anti-HIV (human immunodeficiency virus) sulfur-containing polycyclic-hydroxypyridone formamide analogue and application thereof |
| CN113795491B (en) * | 2019-04-30 | 2024-09-03 | 上海拓界生物医药科技有限公司 | Bridged ring-3, 4-dihydro-pyrido [1,2-a ] pyrazine-1, 8-dione compounds and pharmaceutical uses thereof |
| CN114426540B (en) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | Pyrido [1,2-a ] pyrazine-1, 8-dione prodrug derivatives, preparation method and application thereof |
| TW202227445A (en) * | 2020-10-30 | 2022-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | Use of inhibiting genetically defective hiv virus |
| EP4389745A4 (en) * | 2021-06-03 | 2025-10-01 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Pyridone compound with integrase-inhibiting activity and pharmaceutical use thereof |
| CN114230579A (en) * | 2021-11-12 | 2022-03-25 | 南京艾迪医药科技有限公司 | Polycyclic carbamoylpyridone derivatives, process for their preparation and pharmaceutical compositions containing them |
| CN120424092B (en) * | 2025-07-02 | 2025-09-12 | 中国人民解放军军事科学院军事医学研究院 | Bunyavirus inhibitor and its preparation method and use |
-
2006
- 2006-04-28 UA UAA200711345A patent/UA96568C2/en unknown
- 2006-04-28 CN CN200680022891.4A patent/CN101212903B/en active Active
-
2007
- 2007-10-18 ZA ZA200708970A patent/ZA200708970B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101212903B (en) | 2013-07-24 |
| CN101212903A (en) | 2008-07-02 |
| ZA200708970B (en) | 2008-07-30 |
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