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NO20081787L - Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet - Google Patents

Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Info

Publication number
NO20081787L
NO20081787L NO20081787A NO20081787A NO20081787L NO 20081787 L NO20081787 L NO 20081787L NO 20081787 A NO20081787 A NO 20081787A NO 20081787 A NO20081787 A NO 20081787A NO 20081787 L NO20081787 L NO 20081787L
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NO
Norway
Prior art keywords
group
hydrogen atom
new
binding activity
receptor binding
Prior art date
Application number
NO20081787A
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English (en)
Inventor
Mamoru Matsuda
Toshiyuki Mori
Kenji Kawashima
Masato Nagatsuka
Sachiko Kobayashi
Minoru Yamamoto
Masatomo Kato
Miwa Takai
Tomoko Oda
Original Assignee
Santen Pharmaceutical Co Inc
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Publication date
Application filed by Santen Pharmaceutical Co Inc filed Critical Santen Pharmaceutical Co Inc
Publication of NO20081787L publication Critical patent/NO20081787L/no

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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

En syntese av nye 1,2-dihydrokinolinderivater og deres farmakologiske virkning. En forbindelse representert ved den generelle formel (1) eller et salt derav er effektiv når det gjelder behandling av en glukokortikoid reseptorrelatert sykdom. I formelen betyr ring X betyr en benzenring eller en pyridinring; R1 betyr et halogenatom, en alkylgruppe, en hydroksygruppe, en alkoksygruppe, en aminogruppe eller lignende; p betyr et helt tall fra 0 til 5; R2 betyr et halogenatom, en alkylgruppe, en hydroksygruppe eller lignende; q betyr et helt tall fra 0 til 2; R3 betyr et hydrogenatom, en alkylgruppe, en alkenylgruppe eller lignende; R4 og R5 representerer et hydrogenatom eller lignende; R6 betyr et hydrogenatom eller lignende; A betyr en alkylengruppe eller lignende og R7 betyr OR8, NR8R9, SR8, S(0)R8 eller S(0)2R8, hvori R8 betyr en arylgruppe, en heterosyklisk gruppe eller lignende og R9 betyr et hydrogenatom eller lignende.
NO20081787A 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet NO20081787L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005266622 2005-09-14
JP2006027128 2006-02-03
PCT/JP2006/318674 WO2007032556A1 (ja) 2005-09-14 2006-09-14 グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体

Publications (1)

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NO20081787L true NO20081787L (no) 2008-06-10

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NO20081787A NO20081787L (no) 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Country Status (12)

Country Link
US (2) US8017775B2 (no)
EP (1) EP1944290B1 (no)
KR (1) KR101390094B1 (no)
CN (4) CN102311385B (no)
AU (1) AU2006289751A1 (no)
BR (1) BRPI0615892A2 (no)
CA (1) CA2621292C (no)
ES (1) ES2455142T3 (no)
NO (1) NO20081787L (no)
PL (1) PL1944290T3 (no)
RU (1) RU2008114369A (no)
WO (1) WO2007032556A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2621292C (en) 2005-09-14 2014-05-27 Santen Pharmaceutical Co., Ltd. 1-2-dihydroquinoline derivative having glucocorticoid receptor binding actvity
EP1995242B1 (en) 2006-03-14 2012-11-07 Santen Pharmaceutical Co., Ltd Novel 1,2,3,4-tetrahydroquinoxaline derivative having glucocorticoid receptor binding activity
CA2668596A1 (en) 2006-11-14 2008-05-22 Santen Pharmaceutical Co., Ltd. Novel 1,2-dihydroquinoline derivative having substituted phenylamino lower alkyl group and ester-introduced phenyl group as substituents
JP2008255112A (ja) * 2007-03-13 2008-10-23 Santen Pharmaceut Co Ltd ２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト
MX2009012885A (es) * 2007-05-29 2009-12-10 Santen Pharmaceutical Co Ltd Nuevo derivado de 1,2,3,4-tetrahidroquinoxalina que tiene, como sustituyente, grupo fenilo que tiene estructura de ester de acido sulfonico o estructura de amida de acido sulfonico introducida en este, y tiene actividad de enlace al receptor de gluco
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
JP2009084274A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd 新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
WO2009035067A1 (ja) * 2007-09-13 2009-03-19 Santen Pharmaceutical Co., Ltd. １，３，３－トリメチル－７－フェニル－３，４－ジヒドロ－１ｈ－キノキサリン－２－オン誘導体からなるグルココルチコイド受容体アゴニスト
EA019091B1 (ru) * 2008-05-12 2014-01-30 Сантен Фармасьютикал Ко., Лтд. Агонист глюкокортикоидного рецептора, включающий 2,2,4-триметил-6-фенил-1,2-дигидрохинолиновые производные, содержащие замещенную оксигруппу
MX2011002677A (es) * 2008-09-12 2011-04-12 Santen Pharma Co Ltd Agonista del receptor de glucocorticoide que comprende nuevos derivados de 1,2,3,-4-tetrahidroquinoxalina que contienen un grupo fenilo que tiene una estructura de ester de acido sulfonico introducida en el mismo como sustituyente.
US8802869B2 (en) 2011-02-09 2014-08-12 Santen Pharmaceutical Co., Ltd. 3-hydroxy-6H-benzo [c] chromene-6-one derivative and manufacturing method thereof
US20120316199A1 (en) 2011-06-07 2012-12-13 Ward Keith W Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
US20140371459A1 (en) * 2012-01-20 2014-12-18 Santen Pharmaceutical Co., Ltd. Industrial process for preparation of 1,2-dihydroquinoline derivative or a salt thereof, and intermediate for preparation thereof
RU2644944C1 (ru) * 2017-04-06 2018-02-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Способ получения (Z)-этил 2-(4-(4-хлорфенил)-2,4-диоксо-3-(3-оксо-3,4-дигидрохиноксалин-2(1Н)-илиден)бутанамидо)-4-метил-5-фенилтиофен-3-карбоксилата
WO2018230713A1 (ja) 2017-06-16 2018-12-20 学校法人同志社 カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用
KR102619458B1 (ko) 2017-06-16 2023-12-29 학교법인 도시샤 mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용

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BRPI0615892A2 (pt) 2011-05-31
ES2455142T3 (es) 2014-04-14
CA2621292A1 (en) 2007-03-22
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