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NO20050068L - Nye karboksamid-forbindelser med en mch-antagonist-virkning, medikamenter inneholdende disse forbindelsene, og fremgangsmater for fremstilling derav - Google Patents

Nye karboksamid-forbindelser med en mch-antagonist-virkning, medikamenter inneholdende disse forbindelsene, og fremgangsmater for fremstilling derav

Info

Publication number
NO20050068L
NO20050068L NO20050068A NO20050068A NO20050068L NO 20050068 L NO20050068 L NO 20050068L NO 20050068 A NO20050068 A NO 20050068A NO 20050068 A NO20050068 A NO 20050068A NO 20050068 L NO20050068 L NO 20050068L
Authority
NO
Norway
Prior art keywords
compounds
preparing
methods
drugs containing
antagonist effect
Prior art date
Application number
NO20050068A
Other languages
English (en)
Inventor
Heike-Andrea Wieland
Martin Lenter
Klaus Rudolf
Thorsten Lehmann-Lintz
Stephan Georg Mueller
Ralf Richard Hermann Lotz
Dirk Stenkamp
Philipp Lustenberger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20050068L publication Critical patent/NO20050068L/no

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Foreliggende oppfinnelse angår karboksamid-forbindelser med den generelle formel I a r'¿n'' v n a-^w^itB ' hvor gruppene og restene A, B, W, X, Y, Z, R', R^, R' og k har betydningene som er oppgitt i krav 1. Videre angår oppfinnelsen en fremgangsmåte for fremstilling av de ovennevnte karboksamider, så vel som farmasøytiske preparater som inneholder minst ett karboksamid ifølge oppfinnelsen. På bakgrunn av deies MCH-reseptorantagonistiske virkning er de farmasøytiske preparater ifølge oppfinnelsen egnet for behandling av metabolske lidelser og/eller spiseforstyrrelser, spesielt fedme, bulimi, anoreksi, hyperfagi og diabetes.
NO20050068A 2002-08-24 2005-01-06 Nye karboksamid-forbindelser med en mch-antagonist-virkning, medikamenter inneholdende disse forbindelsene, og fremgangsmater for fremstilling derav NO20050068L (no)

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DE10238865A DE10238865A1 (de) 2002-08-24 2002-08-24 Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP2003/009099 WO2004024702A1 (de) 2002-08-24 2003-08-16 Neue carbonsäureamid-verbindungen mit mch-antagonistischer wirkung, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

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CN1273451C (zh) * 2000-12-22 2006-09-06 先灵公司 哌啶mch拮抗剂及其治疗肥胖症的用途
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds

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AR043046A1 (es) 2005-07-13
WO2004024702A1 (de) 2004-03-25
DE10238865A1 (de) 2004-03-11
PE20040974A1 (es) 2005-01-12
BR0313790A (pt) 2005-07-12
ECSP055615A (es) 2005-05-30
RS20050173A (sr) 2007-09-21
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KR20050040928A (ko) 2005-05-03
EA012834B1 (ru) 2009-12-30
CA2496563A1 (en) 2004-03-25
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CN1678591A (zh) 2005-10-05
UA82853C2 (en) 2008-05-26

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