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NO20033683L - 2,4-disubstituerte pyrimidin-5-karboksamidderivater som KCNQ kaliumkanal modulatorer - Google Patents

2,4-disubstituerte pyrimidin-5-karboksamidderivater som KCNQ kaliumkanal modulatorer

Info

Publication number
NO20033683L
NO20033683L NO20033683A NO20033683A NO20033683L NO 20033683 L NO20033683 L NO 20033683L NO 20033683 A NO20033683 A NO 20033683A NO 20033683 A NO20033683 A NO 20033683A NO 20033683 L NO20033683 L NO 20033683L
Authority
NO
Norway
Prior art keywords
potassium channel
channel modulators
carboxamide derivatives
kcnq potassium
disubstituted pyrimidine
Prior art date
Application number
NO20033683A
Other languages
English (en)
Norwegian (no)
Other versions
NO20033683D0 (no
Inventor
Piyasena Hewawasam
Dharmpal S Dodd
Charles D Weaver
Pierre Dextraze
Valentin K Gribkoff
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20033683D0 publication Critical patent/NO20033683D0/no
Publication of NO20033683L publication Critical patent/NO20033683L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20033683A 2001-02-20 2003-08-19 2,4-disubstituerte pyrimidin-5-karboksamidderivater som KCNQ kaliumkanal modulatorer NO20033683L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26980001P 2001-02-20 2001-02-20
PCT/US2002/004305 WO2002066036A1 (fr) 2001-02-20 2002-02-14 Derives de 2,4-disubstitue pyrimidine-5-carboxamide en tant que modulateur des canaux potassium kcnq

Publications (2)

Publication Number Publication Date
NO20033683D0 NO20033683D0 (no) 2003-08-19
NO20033683L true NO20033683L (no) 2003-10-17

Family

ID=23028698

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033683A NO20033683L (no) 2001-02-20 2003-08-19 2,4-disubstituerte pyrimidin-5-karboksamidderivater som KCNQ kaliumkanal modulatorer

Country Status (10)

Country Link
US (1) US20020183335A1 (fr)
EP (1) EP1361879A1 (fr)
JP (1) JP2005508833A (fr)
CA (1) CA2438231A1 (fr)
CZ (1) CZ20032233A3 (fr)
HU (1) HUP0303841A2 (fr)
MX (1) MXPA03007395A (fr)
NO (1) NO20033683L (fr)
PL (1) PL372944A1 (fr)
WO (1) WO2002066036A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2463989C (fr) 2001-10-17 2012-01-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Derives pyrimidine, compositions pharmaceutiques contenant ces composes, utilisation et procede de fabrication de ces composes
EP1453516A2 (fr) 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament
US7205307B2 (en) 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
US7176310B1 (en) * 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
EP1534687B1 (fr) * 2002-08-21 2006-09-27 Glaxo Group Limited Derives de 2-phenylamino-4-trifluoromethyl-5-(benzyl- ou pyridin-4-ylmethyl)carbamoylpyrimidine comme modulateurs selectifs du recepteur cannabinoide cb2
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
US7459460B2 (en) * 2003-05-28 2008-12-02 Bristol-Myers Squibb Company Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
JP2007521287A (ja) * 2003-07-02 2007-08-02 バーテックス　ファーマシューティカルズ　インコーポレイテッド 電位依存性イオンチャネルの調節因子として有用なピリミジン
DK2305221T3 (en) * 2003-12-01 2015-08-24 Kudos Pharm Ltd DNA damage repair inhibitors for the treatment of cancer
GB0402356D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
GB0404105D0 (en) * 2004-02-24 2004-03-31 Glaxo Group Ltd Novel compounds
TWI349666B (en) 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
DE602005024382D1 (de) 2004-04-13 2010-12-09 Astellas Pharma Inc Polycyclische pyrimidine als kaliumionenkanal-modulatoren
WO2006047504A1 (fr) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Amides aromatiques en tant qu’inhibiteurs de kinase c-fms
EP1809290A2 (fr) 2004-11-03 2007-07-25 Vertex Pharmaceuticals Incorporated Derives de la pyrimidine en tant que modulateurs de canaux ioniques et leurs methodes d'utilisation
UA92340C2 (en) * 2005-03-03 2010-10-25 Х. Луннбек А/С Substituted pyridine derivatives
MX2007010547A (es) * 2005-03-03 2007-10-03 Lundbeck & Co As H Derivados de piridina sustituidos.
WO2006100212A1 (fr) * 2005-03-22 2006-09-28 Neurosearch A/S Pyrazolyl-pyrimidines comme agents de modulation de la voie du potassium et leur utilisation medicale
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
WO2006130493A2 (fr) * 2005-05-31 2006-12-07 Vertex Pharmaceuticals Incorporated Heterocycles utiles comme modulateurs de canaux ioniques
CN101258133A (zh) * 2005-09-09 2008-09-03 H.隆德贝克有限公司 嘧啶衍生物和它们作为kcnq钾通道开放剂的用途
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
WO2008104869A1 (fr) 2007-02-26 2008-09-04 Pfizer Products Inc. Composés hétérocycliques utiles dans le traitement de maladies et de conditions
JP5557832B2 (ja) 2008-03-18 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換４−ヒドロキシピリジン−５−カルボキサミド
TWI504395B (zh) 2009-03-10 2015-10-21 Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
TW201038565A (en) 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
TWI461197B (zh) 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
KR101449348B1 (ko) * 2010-07-08 2014-10-08 화이자 인코포레이티드 Ｋｖ７ 칼륨 채널 개방제로서의 피페리디닐 피리미딘 아미드
TWI522349B (zh) 2010-08-27 2016-02-21 歌林達股份有限公司 作為ｋｃｎｑ２／３調節劑之被取代之２－氧基－喹啉－３－甲醯胺
KR101983979B1 (ko) 2010-08-27 2019-05-30 그뤼넨탈 게엠베하 Ｋｃｎｑ２／３ 조절제로서의 치환된 ２-옥소- 및 ２-티옥소-디하이드로퀴놀린-３-카복스아미드
AU2011295406B2 (en) 2010-08-27 2015-08-06 Grunenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
AU2011297937B2 (en) 2010-09-01 2015-10-01 Grunenthal Gmbh Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators
US9168259B2 (en) 2010-10-20 2015-10-27 Grünenthal GmbH Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
EA022582B1 (ru) 2010-10-20 2016-01-29 Грюненталь Гмбх Замещенные 6-аминоникотинамиды в качестве модуляторов kcnq2/3
AU2013248638A1 (en) * 2012-04-18 2014-12-04 Grünenthal GmbH Substituted 4-aminobenzamides as KCNQ2/3 modulators
HUE030859T2 (en) 2012-04-18 2017-06-28 Gruenenthal Gmbh Substituted 6-amino-nicotinamides bearing an OH-containing group as modulators of KCNQ2 / 3
BR112015012420A8 (pt) * 2012-11-28 2017-10-24 Gruenenthal Gmbh amino-arilcarboxamidas substituídas como moduladores de kcnq2/3
WO2014082737A1 (fr) 2012-11-28 2014-06-05 Grunenthal Gmbh Carboxamides spécifiques utilisés en tant que modulateurs des canaux kcnq2/3
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852028A (en) * 1995-12-18 1998-12-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5935966A (en) * 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5811428A (en) * 1995-12-18 1998-09-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
TW550258B (en) * 1999-05-31 2003-09-01 Hoffmann La Roche 4-phenyl-pyrimidine derivatives
NZ516743A (en) * 1999-08-04 2004-02-27 Icagen Inc Methods for treating or preventing pain and anxiety
IL157313A0 (en) * 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof

Also Published As

Publication number Publication date
US20020183335A1 (en) 2002-12-05
WO2002066036A1 (fr) 2002-08-29
MXPA03007395A (es) 2003-12-04
NO20033683D0 (no) 2003-08-19
CA2438231A1 (fr) 2002-08-29
HUP0303841A2 (hu) 2004-03-01
CZ20032233A3 (cs) 2004-12-15
JP2005508833A (ja) 2005-04-07
EP1361879A1 (fr) 2003-11-19
PL372944A1 (en) 2005-08-08

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Legal Events

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