NO20032253D0 - Piperazinylpyrazinforbindelser som antagonister av serotonin 5-HT2-reseptorer - Google Patents
Piperazinylpyrazinforbindelser som antagonister av serotonin 5-HT2-reseptorerInfo
- Publication number
- NO20032253D0 NO20032253D0 NO20032253A NO20032253A NO20032253D0 NO 20032253 D0 NO20032253 D0 NO 20032253D0 NO 20032253 A NO20032253 A NO 20032253A NO 20032253 A NO20032253 A NO 20032253A NO 20032253 D0 NO20032253 D0 NO 20032253D0
- Authority
- NO
- Norway
- Prior art keywords
- serotonin
- antagonists
- receptors
- compounds
- piperazinylpyrazine
- Prior art date
Links
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 title 1
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 title 1
- 108091005479 5-HT2 receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 102000006902 5-HT2C Serotonin Receptor Human genes 0.000 abstract 1
- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004244A SE0004244D0 (sv) | 2000-11-20 | 2000-11-20 | Novel compounds and their use |
| US25370200P | 2000-11-28 | 2000-11-28 | |
| PCT/SE2001/002570 WO2002040457A1 (en) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20032253D0 true NO20032253D0 (no) | 2003-05-19 |
| NO20032253L NO20032253L (no) | 2003-07-18 |
| NO325321B1 NO325321B1 (no) | 2008-03-31 |
Family
ID=26655310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20032253A NO325321B1 (no) | 2000-11-20 | 2003-05-19 | Piperazinylpyrazinforbindelser, preparat, fremgangsmate for fremstilling samt anvendelse av slike |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1337518B1 (no) |
| JP (1) | JP4204315B2 (no) |
| KR (1) | KR100831909B1 (no) |
| CN (1) | CN1227237C (no) |
| AT (1) | ATE433962T1 (no) |
| AU (1) | AU1529402A (no) |
| BR (1) | BR0115436A (no) |
| CA (2) | CA2449899C (no) |
| DE (1) | DE60139021D1 (no) |
| DK (1) | DK1337518T3 (no) |
| EA (1) | EA005975B1 (no) |
| ES (1) | ES2328671T3 (no) |
| IL (2) | IL155875A0 (no) |
| MX (1) | MXPA03004391A (no) |
| NO (1) | NO325321B1 (no) |
| NZ (1) | NZ525699A (no) |
| PL (1) | PL360982A1 (no) |
| WO (1) | WO2002040457A1 (no) |
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| DE60330864D1 (de) * | 2002-06-19 | 2010-02-25 | Biovitrum Ab Publ | Neue verbindungen, deren verwendung und herstellung |
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| DK1645558T3 (da) * | 2002-06-19 | 2008-10-06 | Biovitrum Ab Publ | Piperazinylpyraziner som serotonin 5-HT2C receptormodulatorer |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| EP1784390A2 (en) | 2004-08-13 | 2007-05-16 | Amgen Inc. | Substituted benzofused heterocycles |
| EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
| CA2584806C (en) | 2004-11-01 | 2014-06-17 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| WO2007022123A2 (en) | 2005-08-11 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
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| WO2007018248A1 (ja) | 2005-08-10 | 2007-02-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン化合物 |
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| CA2621470A1 (en) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | Bicyclic aromatic substituted pyridone derivative |
| KR20080048502A (ko) | 2005-09-29 | 2008-06-02 | 머크 앤드 캄파니 인코포레이티드 | 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체 |
| WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
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| EP2727585A1 (en) | 2006-05-16 | 2014-05-07 | Takeda Pharmaceutical Company Limited | In-vivo screening method |
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| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| NZ515786A (en) | 1999-05-21 | 2004-01-30 | Biovitrum Ab | Aryl compounds, their preparation and use in the preparation of medicaments for the treatment of serotonin-related disorders |
| IL147108A0 (en) | 1999-06-15 | 2002-08-14 | Du Pont Pharm Co | Substituted heterocycle fused gamma-carbolines |
| DE60002583T2 (de) | 1999-07-29 | 2004-03-25 | Eli Lilly And Co., Indianapolis | Benzofurylpiperazine als serotonin-agonisten |
| DK1204659T3 (da) | 1999-07-29 | 2004-04-05 | Lilly Co Eli | Serotonerge benzofuraner |
| BR0012752A (pt) | 1999-07-29 | 2002-04-02 | Lilly Co Eli | Benzofuril piperazinas e benzofuril homopiperazinas: agonistas de serotonina |
| DE60015146T2 (de) | 1999-07-29 | 2006-02-16 | Eli Lilly And Co., Indianapolis | Serotonerge benzothiophene |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
-
2001
- 2001-11-20 JP JP2002542785A patent/JP4204315B2/ja not_active Expired - Fee Related
- 2001-11-20 MX MXPA03004391A patent/MXPA03004391A/es active IP Right Grant
- 2001-11-20 EA EA200300595A patent/EA005975B1/ru not_active IP Right Cessation
- 2001-11-20 DE DE60139021T patent/DE60139021D1/de not_active Expired - Lifetime
- 2001-11-20 PL PL36098201A patent/PL360982A1/xx unknown
- 2001-11-20 IL IL15587501A patent/IL155875A0/xx active IP Right Grant
- 2001-11-20 EP EP01983901A patent/EP1337518B1/en not_active Expired - Lifetime
- 2001-11-20 CA CA2449899A patent/CA2449899C/en not_active Expired - Fee Related
- 2001-11-20 WO PCT/SE2001/002570 patent/WO2002040457A1/en not_active Ceased
- 2001-11-20 AU AU1529402A patent/AU1529402A/xx not_active Withdrawn
- 2001-11-20 AT AT01983901T patent/ATE433962T1/de not_active IP Right Cessation
- 2001-11-20 NZ NZ525699A patent/NZ525699A/en unknown
- 2001-11-20 BR BR0115436-2A patent/BR0115436A/pt not_active IP Right Cessation
- 2001-11-20 CN CNB018192416A patent/CN1227237C/zh not_active Expired - Fee Related
- 2001-11-20 KR KR1020037006822A patent/KR100831909B1/ko not_active Expired - Fee Related
- 2001-11-20 DK DK01983901T patent/DK1337518T3/da active
- 2001-11-20 ES ES01983901T patent/ES2328671T3/es not_active Expired - Lifetime
- 2001-11-20 CA CA002428905A patent/CA2428905A1/en active Pending
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2003
- 2003-05-12 IL IL155875A patent/IL155875A/en not_active IP Right Cessation
- 2003-05-19 NO NO20032253A patent/NO325321B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004531465A (ja) | 2004-10-14 |
| CN1227237C (zh) | 2005-11-16 |
| CN1520404A (zh) | 2004-08-11 |
| MXPA03004391A (es) | 2004-05-31 |
| HK1066810A1 (en) | 2005-04-01 |
| DK1337518T3 (da) | 2009-10-19 |
| AU1529402A (en) | 2002-05-27 |
| EP1337518A1 (en) | 2003-08-27 |
| JP4204315B2 (ja) | 2009-01-07 |
| ATE433962T1 (de) | 2009-07-15 |
| IL155875A0 (en) | 2003-12-23 |
| BR0115436A (pt) | 2004-01-06 |
| KR100831909B1 (ko) | 2008-05-26 |
| DE60139021D1 (de) | 2009-07-30 |
| EA005975B1 (ru) | 2005-08-25 |
| EP1337518B1 (en) | 2009-06-17 |
| PL360982A1 (en) | 2004-09-20 |
| EA200300595A1 (ru) | 2003-10-30 |
| NO325321B1 (no) | 2008-03-31 |
| CA2449899C (en) | 2010-04-06 |
| IL155875A (en) | 2007-06-17 |
| ES2328671T3 (es) | 2009-11-17 |
| NO20032253L (no) | 2003-07-18 |
| WO2002040457A1 (en) | 2002-05-23 |
| CA2428905A1 (en) | 2002-05-23 |
| CA2449899A1 (en) | 2002-05-23 |
| NZ525699A (en) | 2005-03-24 |
| KR20030060946A (ko) | 2003-07-16 |
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