NO20025527L - <Beta>-karbolinderivater for anvendelse som inhibitorer av fosfodiesterase - Google Patents

<Beta>-karbolinderivater for anvendelse som inhibitorer av fosfodiesterase

Info

Publication number: NO20025527L
Authority: NO; Norway
Prior art keywords: beta; phosphodiesterase inhibitors; carboline derivatives; carboline; derivatives
Prior art date: 2000-05-17

Application number

NO20025527A

Other languages

English (en)

Other versions

NO20025527D0 (no

NO324251B1 (no

Inventor

Zhihua Sui

Mark J Macielag

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2002-11-18

Publication date

2003-01-16

2002-11-18 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2002-11-18 Publication of NO20025527D0 publication Critical patent/NO20025527D0/no

2003-01-16 Publication of NO20025527L publication Critical patent/NO20025527L/no

2007-09-17 Publication of NO324251B1 publication Critical patent/NO324251B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20025527A 2000-05-17 2002-11-18 <Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament NO324251B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20466700P	2000-05-17	2000-05-17
PCT/US2001/014357 WO2001087038A2 (en)	2000-05-17	2001-05-03	β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

Publications (3)

Publication Number	Publication Date
NO20025527D0 NO20025527D0 (no)	2002-11-18
NO20025527L true NO20025527L (no)	2003-01-16
NO324251B1 NO324251B1 (no)	2007-09-17

Family

ID=22758909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20025527A NO324251B1 (no)	2000-05-17	2002-11-18	<Beta>-karbolinderivater, farmasoytisk preparat inneholdende samme, fremgangsmate for fremstilling av farmasoytisk preparat ved anvendelse av beta-karbolinderivater for fremstilling av medikament

Country Status (31)

Country	Link
US (2)	US6492358B2 (no)
EP (1)	EP1289985B1 (no)
JP (1)	JP5014551B2 (no)
KR (1)	KR20030031482A (no)
CN (1)	CN1255403C (no)
AR (1)	AR028576A1 (no)
AT (1)	ATE256127T1 (no)
AU (2)	AU2001261167B2 (no)
BG (1)	BG66141B1 (no)
CA (1)	CA2409715C (no)
CZ (1)	CZ20023934A3 (no)
DE (1)	DE60101479T2 (no)
DK (1)	DK1289985T3 (no)
ES (1)	ES2211806T3 (no)
GE (1)	GEP20053511B (no)
HR (1)	HRP20020910B1 (no)
HU (1)	HUP0302412A3 (no)
IL (2)	IL152873A0 (no)
MX (1)	MXPA02011426A (no)
MY (1)	MY128479A (no)
NO (1)	NO324251B1 (no)
NZ (1)	NZ522731A (no)
PL (1)	PL205507B1 (no)
PT (1)	PT1289985E (no)
RU (1)	RU2271358C2 (no)
SK (1)	SK16972002A3 (no)
TR (1)	TR200302309T4 (no)
TW (1)	TWI286553B (no)
UA (1)	UA74826C2 (no)
WO (1)	WO2001087038A2 (no)
ZA (1)	ZA200210111B (no)

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JP2004532816A (ja) *	2000-12-08	2004-10-28	スミスクライン・ビーチャム・コーポレイション	抗菌性化合物
US6900220B2 (en) *	2001-01-02	2005-05-31	Syntex (U.S.A.) Llc	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
AU2002246728A1 (en) *	2001-02-12	2002-08-28	Lilly Icos Llc	Carboline derivatives
DE60216233T2 (de) *	2001-02-12	2007-09-27	Lilly Icos Llc, Wilmington	Carbolinderivate
ATE348101T1 (de) *	2001-04-25	2007-01-15	Lilly Icos Llc	Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion
US6992192B2 (en)	2001-06-05	2006-01-31	Lilly Icos Llc.	Carboline derivatives as PDE5 inhibitors
EP1397361B1 (en) *	2001-06-21	2006-08-09	Lilly Icos LLC	Carboline derivatives as pdev inhibitors
ES2289159T3 (es)	2001-11-14	2008-02-01	Ortho-Mcneil Pharmaceutical Corporation	Derivados tetraciclicos sustituidos de pirroloquinolona utilizados como inhibidores de fosfodiesterasa.
EA200901492A1 (ru) *	2002-02-07	2010-08-30	Юниверсити Оф Теннесси Рисерч Фаундейшн	Лечение доброкачественной гиперплазии простаты селективным модулятором рецептора андрогенов (sarm)
CN100349893C (zh) *	2002-06-19	2007-11-21	詹森药业有限公司	用作磷酸二酯酶抑制剂的取代2,4－二氢－吡咯并[3,4－b]喹啉－9－酮衍生物
JP4671123B2 (ja) *	2003-06-23	2011-04-13	小野薬品工業株式会社	新規三環性複素環化合物
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JP5501251B2 (ja)	2008-01-11	2014-05-21	アルバニーモレキュラーリサーチ，インコーポレイテッド	Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
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MD4009C2 (ro) *	2008-07-15	2010-08-31	Институт Химии Академии Наук Молдовы	Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
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US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US9353113B2 (en)	2011-03-18	2016-05-31	Ono Pharmaceutical Co., Ltd.	Tetrahydrocarboline derivative
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
US10092574B2 (en)	2012-09-26	2018-10-09	Valorisation-Recherche, Limited Partnership	Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
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2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en not_active Ceased
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Withdrawn
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown

Also Published As

Publication number	Publication date
JP2003533453A (ja)	2003-11-11
PL365445A1 (en)	2005-01-10
BG66141B1 (bg)	2011-07-29
WO2001087038A3 (en)	2002-05-16
CA2409715A1 (en)	2001-11-22
UA74826C2 (en)	2006-02-15
US6492358B2 (en)	2002-12-10
JP5014551B2 (ja)	2012-08-29
PL205507B1 (pl)	2010-04-30
US6864253B2 (en)	2005-03-08
HK1051368A1 (en)	2003-08-01
WO2001087038A2 (en)	2001-11-22
MY128479A (en)	2007-02-28
HUP0302412A2 (hu)	2003-11-28
AU2001261167B2 (en)	2006-10-05
HUP0302412A3 (en)	2007-02-28
DE60101479D1 (en)	2004-01-22
MXPA02011426A (es)	2004-09-06
SK16972002A3 (sk)	2003-11-04
GEP20053511B (en)	2005-05-10
CN1255403C (zh)	2006-05-10
TR200302309T4 (tr)	2004-02-23
CA2409715C (en)	2010-09-14
EP1289985B1 (en)	2003-12-10
HRP20020910A2 (en)	2004-12-31
HRP20020910B1 (hr)	2011-02-28
US20030166641A1 (en)	2003-09-04
CZ20023934A3 (cs)	2003-10-15
BG107285A (bg)	2003-07-31
US20020010189A1 (en)	2002-01-24
ES2211806T3 (es)	2004-07-16
IL152873A (en)	2012-01-31
CN1446217A (zh)	2003-10-01
AR028576A1 (es)	2003-05-14
EP1289985A2 (en)	2003-03-12
PT1289985E (pt)	2004-03-31
NO20025527D0 (no)	2002-11-18
IL152873A0 (en)	2003-06-24
ATE256127T1 (de)	2003-12-15
RU2271358C2 (ru)	2006-03-10
DE60101479T2 (de)	2005-04-28
KR20030031482A (ko)	2003-04-21
TWI286553B (en)	2007-09-11
ZA200210111B (en)	2004-03-12
DK1289985T3 (da)	2004-04-05
NO324251B1 (no)	2007-09-17
NZ522731A (en)	2004-09-24
AU6116701A (en)	2001-11-26

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DK1222193T3 (da)	2003-12-01	Imidazolderivater som phosphodiesterase VII-inhibitorer
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AU2002348365A1 (en)	2003-05-26	Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors

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