ATE348101T1 - Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion - Google Patents

Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion

Info

Publication number: ATE348101T1
Authority: AT; Austria
Prior art keywords: inhibitors; phospphodiesterase; pde5; treatment; cardiovascular diseases
Prior art date: 2001-04-25

Application number

AT02766739T

Other languages

English (en)

Inventor

Jason Scott Sawyer

Mark W Orme

James D Copp

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-25

Filing date

2002-04-02

Publication date

2007-01-15

2002-04-02 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE348101T1 publication Critical patent/ATE348101T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02766739T 2001-04-25 2002-04-02 Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion ATE348101T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28673001P	2001-04-25	2001-04-25

Publications (1)

Publication Number	Publication Date
ATE348101T1 true ATE348101T1 (de)	2007-01-15

Family

ID=23099912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02766739T ATE348101T1 (de)	2001-04-25	2002-04-02	Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion

Country Status (9)

Country	Link
US (1)	US7115621B2 (de)
EP (1)	EP1383765B1 (de)
JP (1)	JP4216606B2 (de)
AT (1)	ATE348101T1 (de)
CA (1)	CA2441792C (de)
DE (1)	DE60216745T2 (de)
ES (1)	ES2278956T3 (de)
MX (1)	MXPA03009750A (de)
WO (1)	WO2002088123A1 (de)

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TWI329111B (en)	2002-05-24	2010-08-21	X Ceptor Therapeutics Inc	Azepinoindole and pyridoindole derivatives as pharmaceutical agents
JP4671123B2 (ja)	2003-06-23	2011-04-13	小野薬品工業株式会社	新規三環性複素環化合物
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
AU2005222632B2 (en)	2004-03-15	2012-02-09	Ptc Therapeutics, Inc.	Carboline derivatives useful in the inhibition of angiogenesis
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8063214B2 (en) *	2004-10-28	2011-11-22	Dr. Reddy's Laboratories Limited	Polymorphic forms of tadalafil
AR051780A1 (es) *	2004-11-29	2007-02-07	Japan Tobacco Inc	Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
JP4997976B2 (ja) *	2004-12-22	2012-08-15	小野薬品工業株式会社	三環式化合物およびその用途
EP1747779A1 (de)	2005-07-28	2007-01-31	Laboratorios Del Dr. Esteve, S.A.	Tetrahydro-b-carbolinsulfonamid-Derivate als 5-HT6 Liganden
CA2616366A1 (en) *	2005-07-29	2007-02-08	Concert Pharmaceuticals Inc.	Novel pharmaceutical compounds
WO2007020521A1 (en) *	2005-08-16	2007-02-22	Pharmacia & Upjohn Company Llc	Pyridoyrazinones as pde-5 inhibitors
WO2007110734A1 (en) *	2006-03-24	2007-10-04	Glenmark Pharmaceuticals Limited	Process for the preparation of tadalafil
MX2010003149A (es) *	2007-09-20	2010-11-10	D2E Llc	Derivados que contienen fluor de pirido[4,3-b]indoles hidrogenados con propiedades neuroprotectoras y de mejoramiento de cognicion, proceso de preparacion y uso.
JP5501251B2 (ja)	2008-01-11	2014-05-21	アルバニーモレキュラーリサーチ，インコーポレイテッド	Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
EP2448585B1 (de) *	2009-07-01	2014-01-01	Albany Molecular Research, Inc.	Azinon-substituiertes azepin[b]indol und pyrido-pyrrolo-azepin mch-1 antagonisten, verfahren zur herstellung und verwendung davon
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US9353113B2 (en)	2011-03-18	2016-05-31	Ono Pharmaceutical Co., Ltd.	Tetrahydrocarboline derivative
CN102391323B (zh) *	2011-10-18	2013-09-25	首都医科大学	四氢-β-咔啉衍生物、其制备方法及其用途
TW201710258A (zh)	2015-06-23	2017-03-16	碩騰服務公司	咔啉抗寄生蟲藥

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* Cited by examiner, † Cited by third party
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ES273769A1 (es) *	1961-01-18	1962-06-01	Geigy Ag J R	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
JPS5543475B2 (de) *	1972-09-14	1980-11-06
US4336260A (en) *	1977-12-08	1982-06-22	The Dow Chemical Company	Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression
JPS5936676A (ja) *	1982-08-20	1984-02-28	Tanabe Seiyaku Co Ltd	β−カルボリン誘導体の新規製法
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
GB9401090D0 (en) *	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514473D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
ES2169857T3 (es) *	1996-04-04	2002-07-16	Hoffmann La Roche	Uso de derivados de tetrahidro-beta-carbolinas como agentes antimetastaticos.
ES2175404T3 (es) *	1996-05-10	2002-11-16	Icos Corp	Derivados de carbolina.
CA2253910A1 (en)	1996-05-11	1997-11-20	King's College London	Pyrazines
US6043252A (en) *	1997-05-05	2000-03-28	Icos Corporation	Carboline derivatives
EP1114048A1 (de)	1998-09-16	2001-07-11	Agnès Bombrun	Carbolin-derivate als cgmp phosphodiesterase-inhibitoren
DK1200090T3 (da) *	1999-08-03	2013-11-25	Icos Corp	Farmaceutisk formulering omfattende en beta-carbolin og dens anvendelse til behandling af seksuel dysfunktion
UA74826C2 (en) *	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
AU2001268064A1 (en) *	2000-06-07	2001-12-17	Lilly Icos Llc	Derivatives of 2,3,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
EP1289990A1 (de)	2000-06-08	2003-03-12	Lilly Icos LLC	Tetrazyklische diketopierazin verbidnungen als pdev inhibitoren
DE60121461T2 (de) *	2000-10-03	2007-02-08	Lilly Icos Llc, Wilmington	Kondensierte pyridoindolderivate
WO2002036593A1 (en)	2000-11-06	2002-05-10	Lilly Icos Llc	Indole derivatives as pde5-inhibitors

2002
- 2002-04-02 AT AT02766739T patent/ATE348101T1/de not_active IP Right Cessation
- 2002-04-02 ES ES02766739T patent/ES2278956T3/es not_active Expired - Lifetime
- 2002-04-02 DE DE60216745T patent/DE60216745T2/de not_active Expired - Lifetime
- 2002-04-02 MX MXPA03009750A patent/MXPA03009750A/es active IP Right Grant
- 2002-04-02 JP JP2002585422A patent/JP4216606B2/ja not_active Expired - Fee Related
- 2002-04-02 US US10/471,476 patent/US7115621B2/en not_active Expired - Fee Related
- 2002-04-02 CA CA2441792A patent/CA2441792C/en not_active Expired - Fee Related
- 2002-04-02 WO PCT/US2002/010367 patent/WO2002088123A1/en not_active Ceased
- 2002-04-02 EP EP02766739A patent/EP1383765B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20040147542A1 (en)	2004-07-29
CA2441792C (en)	2010-08-03
DE60216745D1 (de)	2007-01-25
JP2004532852A (ja)	2004-10-28
DE60216745T2 (de)	2007-05-16
ES2278956T3 (es)	2007-08-16
JP4216606B2 (ja)	2009-01-28
MXPA03009750A (es)	2004-06-30
US7115621B2 (en)	2006-10-03
CA2441792A1 (en)	2002-11-07
EP1383765A1 (de)	2004-01-28
WO2002088123A1 (en)	2002-11-07
EP1383765B1 (de)	2006-12-13

Publication	Publication Date	Title
DE60216745D1 (de)	2007-01-25	Carbolin Derivate als Hemmstoffe von Phospphodiesterase 5 (PDE5) zur Behandlung kardiovaskulärer Erkrankungen und der erektilen Dysfunktion
ATE302775T1 (de)	2005-09-15	Carbolinderivate
EA200200208A1 (ru)	2002-08-29	Синергитическая композиция
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
EA200700099A1 (ru)	2007-08-31	Производные пиридина
AU5584901A (en)	2001-10-30	Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
TNSN03144A1 (en)	2005-12-23	Pyrrolopyrimidines as protein kinase inhibitors
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
ATE307810T1 (de)	2005-11-15	Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
ATE346067T1 (de)	2006-12-15	Carbolinderivate
ATE332903T1 (de)	2006-08-15	Kondensierte pyridoindolderivate
MXPA04005886A (es)	2004-09-13	Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
DE60112306D1 (de)	2005-09-01	Kondensierte pyrazindionderivate als pde5 inhibitore
DE60312736D1 (de)	2007-05-03	1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
AP2003002929A0 (en)	2003-12-31	Pyrrolopyrimidines as protein kinase inhibitors
ECSP055809A (es)	2005-08-11	Inhibidores 4-oxo-1-(3-fenil sustituido)-1,4-dihidro-1,8-naftiridina-3-carboxamida de la fosfodiesterasa-4
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE302776T1 (de)	2005-09-15	Kondensierte pyridoindolderivate
DE60226970D1 (de)	2008-07-17	Pyrazinoä1',2':1,6ü-pyridoä3,4-bü indole-1,4-dionderivate
ATE337320T1 (de)	2006-09-15	Indolderivate als pde5-inhibitoren
MXPA03004023A (es)	2004-02-12	Compuestos quimicos.
ATE297926T1 (de)	2005-07-15	Hexahydropyrazino(1'2':1,6)-pyrido(3,4-b)indole 1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
ATE335742T1 (de)	2006-09-15	Carbolinderivate als pdev inhibitoren

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties