NO20014013L - 16-halogen-epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem - Google Patents

16-halogen-epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem

Info

Publication number: NO20014013L
Authority: NO; Norway
Prior art keywords: halogen; processes; preparation; pharmaceutical use; epothilone derivatives
Prior art date: 1999-02-18

Application number

NO20014013A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014013D0 (no

Inventor

Ulrich Klar

Werner Skuballa

Bernd Buchmann

Wolfgang Schwede

Michael Schirner

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-18

Filing date

2001-08-17

Publication date

2001-10-18

1999-02-18 Priority claimed from DE19908765A external-priority patent/DE19908765A1/de

1999-11-04 Priority claimed from DE19954230A external-priority patent/DE19954230A1/de

2001-08-17 Application filed by Schering Ag filed Critical Schering Ag

2001-08-17 Publication of NO20014013D0 publication Critical patent/NO20014013D0/no

2001-10-18 Publication of NO20014013L publication Critical patent/NO20014013L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

NO20014013A 1999-02-18 2001-08-17 16-halogen-epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem NO20014013L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19908765A DE19908765A1 (de)	1999-02-18	1999-02-18	16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954230A DE19954230A1 (de)	1999-11-04	1999-11-04	16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001333 WO2000049021A2 (de)	1999-02-18	2000-02-18	16-halogen-epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Publications (2)

Publication Number	Publication Date
NO20014013D0 NO20014013D0 (no)	2001-08-17
NO20014013L true NO20014013L (no)	2001-10-18

Family

ID=26052117

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014013A NO20014013L (no)	1999-02-18	2001-08-17	16-halogen-epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem

Country Status (27)

Country	Link
US (3)	US6610736B1 (zh)
EP (1)	EP1150980B1 (zh)
JP (1)	JP2002537301A (zh)
KR (1)	KR100718616B1 (zh)
CN (1)	CN1209360C (zh)
AR (1)	AR022636A1 (zh)
AT (1)	ATE370946T1 (zh)
AU (1)	AU3156700A (zh)
BG (1)	BG105802A (zh)
BR (1)	BR0008331A (zh)
CA (1)	CA2361278A1 (zh)
CZ (1)	CZ20012951A3 (zh)
DE (1)	DE50014587D1 (zh)
EA (1)	EA009206B1 (zh)
EE (1)	EE200100431A (zh)
ES (1)	ES2291194T3 (zh)
HR (1)	HRP20010677A2 (zh)
HU (1)	HUP0105478A3 (zh)
IL (1)	IL144519A0 (zh)
MX (1)	MXPA01008328A (zh)
NO (1)	NO20014013L (zh)
NZ (1)	NZ513268A (zh)
PL (1)	PL349863A1 (zh)
SK (1)	SK11852001A3 (zh)
TW (1)	TWI285645B (zh)
WO (1)	WO2000049021A2 (zh)
YU (1)	YU59001A (zh)

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WO1998022461A1 (de)	1996-11-18	1998-05-28	GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)	Epothilone c, d, e und f, deren herstellung und deren verwendung als cytostatische mittel bzw. als pflanzenschutzmittel
WO1999001124A1 (en)	1996-12-03	1999-01-14	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) *	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US20050043376A1 (en) *	1996-12-03	2005-02-24	Danishefsky Samuel J.	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
CA2299608A1 (en) *	1997-08-09	1999-02-18	Schering Aktiengesellschaft	New epothilone derivatives, method for producing same and their pharmaceutical use
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6399638B1 (en)	1998-04-21	2002-06-04	Bristol-Myers Squibb Company	12,13-modified epothilone derivatives
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
US6518421B1 (en)	2000-03-20	2003-02-11	Bristol-Myers Squibb Company	Process for the preparation of epothilone analogs
DE10020899A1 (de) *	2000-04-20	2001-10-25	Schering Ag	9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
BRPI0206509B8 (pt)	2001-01-25	2021-05-25	R Pharm Us Operating Llc	processo para formular, para administração parenteral, um análogo de epotilona, preparação farmacêutica, processo para formar uma composição farmacêutica para administração parental, composição farmacêutica e uso de um análogo de epotilona na preparação de uma composição farmacêutica para o tratamento de câncer
NZ526871A (en)	2001-01-25	2006-01-27	Bristol Myers Squibb Co	Pharmaceutical dosage forms of epothilones for oral administration
IL156578A0 (en) *	2001-01-25	2004-01-04	Bristol Myers Squibb Co	A method for formulating an epothilone analog for pharmaceutical use and pharmaceutical preparations including an epothilone analog
CA2434566A1 (en)	2001-01-25	2002-08-15	Timothy M. Malloy	Parenteral formulation containing epothilone analogs
PL363363A1 (en)	2001-02-20	2004-11-15	Bristol-Myers Squibb Company	Epothilone derivatives for the treatment of refractory tumors
PL363362A1 (en)	2001-02-20	2004-11-15	Bristol-Myers Squibb Company	Treatment of refractory tumors using epothilone derivatives
EP1383490B1 (en)	2001-03-14	2012-04-25	Bristol-Myers Squibb Company	Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases
US6800653B2 (en)	2001-06-01	2004-10-05	Bristol-Myers Squibb Compnay	Epothilone derivatives
WO2003026744A1 (en) *	2001-09-25	2003-04-03	Alcon, Inc.	The use of epothilones and analogs in conjunction with ophthalmic surgery
EP1340498A1 (en) *	2002-03-01	2003-09-03	Schering Aktiengesellschaft	Use of epothilones in the treatment of brain diseases associated with proliferative processes
DK1483251T3 (da)	2002-03-12	2010-04-12	Bristol Myers Squibb Co	C3-cyano-epothilon-derivater
WO2003077903A1 (en)	2002-03-12	2003-09-25	Bristol-Myers Squibb Company	C12-cyano epothilone derivatives
TW200403994A (en)	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en)	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
AU2003243561A1 (en)	2002-06-14	2003-12-31	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
ATE450534T1 (de)	2002-08-23	2009-12-15	Sloan Kettering Inst Cancer	Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung
RU2462463C2 (ru) *	2002-08-23	2012-09-27	Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч	Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
PL375902A1 (en)	2002-09-23	2005-12-12	Bristol-Myers Squibb Company	Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b
EP1559447A1 (en)	2004-01-30	2005-08-03	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism
KR20070084325A (ko) *	2004-11-18	2007-08-24	브리스톨-마이어스 스큅 컴퍼니	익사베필론을 포함하는 장용성 코팅된 비드 및 그의 제조방법
EP1824458A1 (en) *	2004-11-18	2007-08-29	Bristol-Myers Squibb Company	Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
EP1674098A1 (en)	2004-12-23	2006-06-28	Schering Aktiengesellschaft	Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
EP1856255A4 (en)	2005-02-11	2010-01-27	Univ Southern California	PROCESS FOR EXPRESSING PROTEINS VIA DISULPHIDE BRIDGES
CA2607940C (en)	2005-05-18	2009-12-15	Aegera Therapeutics Inc.	Bir domain binding compounds
US20070014978A1 (en) *	2005-07-18	2007-01-18	Anthony Poloso	Method of flame blocking and articles made therefrom
US8008256B2 (en) *	2006-05-01	2011-08-30	University Of Southern California	Combination therapy for treatment of cancer
AU2007250443B2 (en)	2006-05-16	2013-06-13	Pharmascience Inc.	IAP BIR domain binding compounds
EP2065054A1 (en) *	2007-11-29	2009-06-03	Bayer Schering Pharma Aktiengesellschaft	Combinations comprising a prostaglandin and uses thereof
EP2070521A1 (en)	2007-12-10	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Surface-modified nanoparticles
DE102007059752A1 (de)	2007-12-10	2009-06-18	Bayer Schering Pharma Aktiengesellschaft	Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
WO2010056901A2 (en)	2008-11-13	2010-05-20	University Of Southern California	Method of expressing proteins with disulfide bridges with enhanced yields and activity
EP2210584A1 (en)	2009-01-27	2010-07-28	Bayer Schering Pharma Aktiengesellschaft	Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
EP2534170B1 (en)	2010-02-12	2017-04-19	Pharmascience Inc.	Iap bir domain binding compounds
EP2793949B1 (en)	2011-12-23	2018-08-22	Innate Pharma	Enzymatic conjugation of antibodies
WO2014009426A2 (en)	2012-07-13	2014-01-16	Innate Pharma	Screening of conjugated antibodies
EP2916872B1 (en)	2012-11-09	2019-02-27	Innate Pharma	Recognition tags for tgase-mediated conjugation
WO2014140300A1 (en)	2013-03-15	2014-09-18	Innate Pharma	Solid phase tgase-mediated conjugation of antibodies
WO2014202773A1 (en)	2013-06-20	2014-12-24	Innate Pharma	Enzymatic conjugation of polypeptides
CA2914189C (en)	2013-06-21	2023-03-14	Innate Pharma	Enzymatic conjugation of polypeptides
WO2019092148A1 (en)	2017-11-10	2019-05-16	Innate Pharma	Antibodies with functionalized glutamine residues
GB202309910D0 (en) *	2023-06-29	2023-08-16	Implexion Pharma Ab	Therpay

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EP0353732A3 (de) *	1988-08-05	1991-11-06	Ciba-Geigy Ag	Neue Fluorolefine, Verfahren zu deren Herstellung und deren Verwendung
JP2685521B2 (ja)	1988-08-05	1997-12-03	株式会社日立製作所	車両用換気装置
ES2025033T3 (es) *	1989-12-27	1994-10-01	Monsanto Co	Compuestos de piridina sustituidos.
US6441186B1 (en) *	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
CA2299608A1 (en) *	1997-08-09	1999-02-18	Schering Aktiengesellschaft	New epothilone derivatives, method for producing same and their pharmaceutical use
WO2000000485A1 (de) *	1998-06-30	2000-01-06	Schering Aktiengesellschaft	Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung
DE10020517A1 (de) *	2000-04-19	2001-10-25	Schering Ag	Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung

2000
- 2000-02-18 DE DE50014587T patent/DE50014587D1/de not_active Expired - Fee Related
- 2000-02-18 PL PL00349863A patent/PL349863A1/xx not_active Application Discontinuation
- 2000-02-18 BR BR0008331-3A patent/BR0008331A/pt not_active Application Discontinuation
- 2000-02-18 ES ES00909205T patent/ES2291194T3/es not_active Expired - Lifetime
- 2000-02-18 MX MXPA01008328A patent/MXPA01008328A/es active IP Right Grant
- 2000-02-18 US US09/913,495 patent/US6610736B1/en not_active Expired - Fee Related
- 2000-02-18 IL IL14451900A patent/IL144519A0/xx unknown
- 2000-02-18 HU HU0105478A patent/HUP0105478A3/hu unknown
- 2000-02-18 SK SK1185-2001A patent/SK11852001A3/sk unknown
- 2000-02-18 HR HR20010677A patent/HRP20010677A2/hr not_active Application Discontinuation
- 2000-02-18 YU YU59001A patent/YU59001A/sh unknown
- 2000-02-18 EP EP00909205A patent/EP1150980B1/de not_active Expired - Lifetime
- 2000-02-18 NZ NZ513268A patent/NZ513268A/en unknown
- 2000-02-18 EA EA200100826A patent/EA009206B1/ru unknown
- 2000-02-18 WO PCT/EP2000/001333 patent/WO2000049021A2/de not_active Ceased
- 2000-02-18 AT AT00909205T patent/ATE370946T1/de not_active IP Right Cessation
- 2000-02-18 CA CA002361278A patent/CA2361278A1/en not_active Abandoned
- 2000-02-18 AU AU31567/00A patent/AU3156700A/en not_active Abandoned
- 2000-02-18 EE EEP200100431A patent/EE200100431A/xx unknown
- 2000-02-18 JP JP2000599760A patent/JP2002537301A/ja active Pending
- 2000-02-18 KR KR1020017010455A patent/KR100718616B1/ko not_active Expired - Fee Related
- 2000-02-18 CZ CZ20012951A patent/CZ20012951A3/cs unknown
- 2000-02-18 CN CNB008039763A patent/CN1209360C/zh not_active Expired - Fee Related
- 2000-02-21 AR ARP000100714A patent/AR022636A1/es unknown
- 2000-04-19 TW TW089102834A patent/TWI285645B/zh not_active IP Right Cessation
2001
- 2001-08-09 BG BG105802A patent/BG105802A/bg unknown
- 2001-08-17 NO NO20014013A patent/NO20014013L/no not_active Application Discontinuation
2003
- 2003-02-12 US US10/364,337 patent/US6930102B2/en not_active Expired - Fee Related
2005
- 2005-03-25 US US11/090,841 patent/US20050187270A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2002537301A (ja)	2002-11-05
US6610736B1 (en)	2003-08-26
HUP0105478A3 (en)	2002-08-28
HRP20010677A2 (en)	2005-06-30
WO2000049021A2 (de)	2000-08-24
US20050187270A1 (en)	2005-08-25
US6930102B2 (en)	2005-08-16
NZ513268A (en)	2004-05-28
MXPA01008328A (es)	2002-06-04
EP1150980B1 (de)	2007-08-22
AR022636A1 (es)	2002-09-04
WO2000049021A3 (de)	2000-12-28
AU3156700A (en)	2000-09-04
BR0008331A (pt)	2002-01-29
SK11852001A3 (sk)	2002-04-04
KR20010102215A (ko)	2001-11-15
NO20014013D0 (no)	2001-08-17
YU59001A (sh)	2005-07-19
CA2361278A1 (en)	2000-08-24
PL349863A1 (en)	2002-09-23
ES2291194T3 (es)	2008-03-01
CN1209360C (zh)	2005-07-06
CN1341115A (zh)	2002-03-20
CZ20012951A3 (cs)	2001-11-14
KR100718616B1 (ko)	2007-05-16
IL144519A0 (en)	2002-05-23
EA009206B1 (ru)	2007-12-28
DE50014587D1 (de)	2007-10-04
ATE370946T1 (de)	2007-09-15
TWI285645B (en)	2007-08-21
HUP0105478A2 (en)	2002-06-29
EA200100826A1 (ru)	2002-02-28
EE200100431A (et)	2002-12-16
BG105802A (bg)	2002-03-29
US20040014978A1 (en)	2004-01-22
EP1150980A2 (de)	2001-11-07
HK1044945A1 (zh)	2002-11-08

Publication	Publication Date	Title
NO20014013L (no)	2001-10-18	16-halogen-epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem
NO20001409L (no)	2000-05-16	Karboksamidotiazolderivater, fremgangsmÕte for fremstilling derav og farmasøytiske blandinger
HUP0105414A3 (en)	2003-04-28	Pyrrolo-isoquinoline, azepino- and diazepino-indole derivatives, their use and pharmaceutical compisitions containing them
DK1117645T3 (da)	2004-08-02	Arylsubstituerede propanolaminderivater, fremgangsmåder til fremstilling deraf, lægemidler indeholdende disse forbindelser og anvendelse deraf
DK1180518T3 (da)	2007-05-21	5-pyridyl-1,3-azolforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf
EE200200095A (et)	2003-04-15	Sulfonüülkarboksamiidi derivaadid, nende kasutamine, ravim ja nende valmistamismeetod
NO20021379D0 (no)	2002-03-20	Benzodiazepin-derivater, fremstilling og anvendelse derav
DK1202965T3 (da)	2005-02-14	Indolderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse og deres medicinske anvendelse
NO20014487D0 (no)	2001-09-14	Bisykliske heterosykler, farmasöytiske blandinger inneholdende disse forbindelsene og fremgangsmåter forfremstilling av dem
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