EE200100431A - 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine - Google Patents

16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine

Info

Publication number: EE200100431A
Authority: EE; Estonia
Prior art keywords: haloepothilone; derivatives; preparation; pharmaceutical use; pharmaceutical
Prior art date: 1999-02-18

Application number

EEP200100431A

Other languages

English (en)

Estonian (et)

Inventor

Klar Ulrich

Skuballa Werner

Buchmann Bernd

Schwede Wolfgang

Schirner Michael

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-18

Filing date

2000-02-18

Publication date

2002-12-16

1999-02-18 Priority claimed from DE19908765A external-priority patent/DE19908765A1/de

1999-11-04 Priority claimed from DE19954230A external-priority patent/DE19954230A1/de

2000-02-18 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2002-12-16 Publication of EE200100431A publication Critical patent/EE200100431A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

EEP200100431A 1999-02-18 2000-02-18 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine EE200100431A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19908765A DE19908765A1 (de)	1999-02-18	1999-02-18	16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954230A DE19954230A1 (de)	1999-11-04	1999-11-04	16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001333 WO2000049021A2 (de)	1999-02-18	2000-02-18	16-halogen-epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Publications (1)

Publication Number	Publication Date
EE200100431A true EE200100431A (et)	2002-12-16

Family

ID=26052117

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100431A EE200100431A (et)	1999-02-18	2000-02-18	16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine

Country Status (27)

Country	Link
US (3)	US6610736B1 (xx)
EP (1)	EP1150980B1 (xx)
JP (1)	JP2002537301A (xx)
KR (1)	KR100718616B1 (xx)
CN (1)	CN1209360C (xx)
AR (1)	AR022636A1 (xx)
AT (1)	ATE370946T1 (xx)
AU (1)	AU3156700A (xx)
BG (1)	BG105802A (xx)
BR (1)	BR0008331A (xx)
CA (1)	CA2361278A1 (xx)
CZ (1)	CZ20012951A3 (xx)
DE (1)	DE50014587D1 (xx)
EA (1)	EA009206B1 (xx)
EE (1)	EE200100431A (xx)
ES (1)	ES2291194T3 (xx)
HR (1)	HRP20010677A2 (xx)
HU (1)	HUP0105478A3 (xx)
IL (1)	IL144519A0 (xx)
MX (1)	MXPA01008328A (xx)
NO (1)	NO20014013L (xx)
NZ (1)	NZ513268A (xx)
PL (1)	PL349863A1 (xx)
SK (1)	SK11852001A3 (xx)
TW (1)	TWI285645B (xx)
WO (1)	WO2000049021A2 (xx)
YU (1)	YU59001A (xx)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0941227T5 (da)	1996-11-18	2009-10-05	Biotechnolog Forschung Gmbh	Epothilon D, dens fremstilling samt dens anvendelse som cytostatisk middel og som plantebeskyttelsesmiddel
US20050043376A1 (en) *	1996-12-03	2005-02-24	Danishefsky Samuel J.	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
CA2273083C (en)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
US7407975B2 (en) *	1997-08-09	2008-08-05	Bayer Schering Pharma Ag	Epothilone derivatives, method for producing same and their pharmaceutical use
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6380395B1 (en)	1998-04-21	2002-04-30	Bristol-Myers Squibb Company	12, 13-cyclopropane epothilone derivatives
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
US6518421B1 (en) *	2000-03-20	2003-02-11	Bristol-Myers Squibb Company	Process for the preparation of epothilone analogs
DE10020899A1 (de) *	2000-04-20	2001-10-25	Schering Ag	9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
BRPI0206509B8 (pt)	2001-01-25	2021-05-25	R Pharm Us Operating Llc	processo para formular, para administração parenteral, um análogo de epotilona, preparação farmacêutica, processo para formar uma composição farmacêutica para administração parental, composição farmacêutica e uso de um análogo de epotilona na preparação de uma composição farmacêutica para o tratamento de câncer
MXPA03006485A (es)	2001-01-25	2003-09-22	Bristol Myers Squibb Co	Formulacion parenteral que contiene analogos de epotilona.
JP4633331B2 (ja) *	2001-01-25	2011-02-16	ブリストル−マイヤーズスクイブカンパニー	癌治療のためのエポチロン類似体の投与方法
NZ526871A (en) *	2001-01-25	2006-01-27	Bristol Myers Squibb Co	Pharmaceutical dosage forms of epothilones for oral administration
MXPA03007423A (es)	2001-02-20	2003-11-18	Bristol Myers Squibb Co	Derivados de epotilona para tratamiento de tumores refractarios.
EP1385529A4 (en)	2001-02-20	2007-05-09	Bristol Myers Squibb Co	TREATMENT OF REFRACTORY TUMORS USING EPOTHILONE DERIVATIVES
IL157443A0 (en)	2001-03-14	2004-03-28	Bristol Myers Squibb Co	Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent
EP1392664A4 (en)	2001-06-01	2005-01-26	Bristol Myers Squibb Co	EPOTHILONE DERIVATIVES
WO2003026744A1 (en) *	2001-09-25	2003-04-03	Alcon, Inc.	The use of epothilones and analogs in conjunction with ophthalmic surgery
EP1340498A1 (en) *	2002-03-01	2003-09-03	Schering Aktiengesellschaft	Use of epothilones in the treatment of brain diseases associated with proliferative processes
AU2003218107A1 (en)	2002-03-12	2003-09-29	Bristol-Myers Squibb Company	C12-cyano epothilone derivatives
DK1483251T3 (da)	2002-03-12	2010-04-12	Bristol Myers Squibb Co	C3-cyano-epothilon-derivater
TW200403994A (en)	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en)	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
WO2003105828A1 (en)	2002-06-14	2003-12-24	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
PT1506203E (pt) *	2002-08-23	2007-04-30	Sloan Kettering Inst Cancer	Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
RU2462463C2 (ru) *	2002-08-23	2012-09-27	Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч	Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CN1705662B (zh)	2002-09-23	2011-07-06	布里斯托尔-迈尔斯斯奎布公司	埃坡霉素b的制备、分离和纯化的方法,及埃坡霉素b的x-射线晶体结构
EP1559447A1 (en)	2004-01-30	2005-08-03	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism
MX2007005763A (es) *	2004-11-18	2007-07-20	Squibb Bristol Myers Co	Perla recubierta enterica que comprende ixabepilona, y preparacion y administracion de la misma.
EP1824458A1 (en) *	2004-11-18	2007-08-29	Bristol-Myers Squibb Company	Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
EP1674098A1 (en)	2004-12-23	2006-06-28	Schering Aktiengesellschaft	Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
EP2634252B1 (en)	2005-02-11	2018-12-19	University of Southern California	Method of expressing proteins with disulfide bridges
CA2607940C (en)	2005-05-18	2009-12-15	Aegera Therapeutics Inc.	Bir domain binding compounds
US20070014978A1 (en) *	2005-07-18	2007-01-18	Anthony Poloso	Method of flame blocking and articles made therefrom
WO2007130501A2 (en) *	2006-05-01	2007-11-15	University Of Southern California	Combination therapy for treatment of cancer
SG10201407457UA (en)	2006-05-16	2014-12-30	Pharmascience Inc	Iap bir domain binding compounds
EP2065054A1 (en) *	2007-11-29	2009-06-03	Bayer Schering Pharma Aktiengesellschaft	Combinations comprising a prostaglandin and uses thereof
DE102007059752A1 (de)	2007-12-10	2009-06-18	Bayer Schering Pharma Aktiengesellschaft	Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
EP2070521A1 (en)	2007-12-10	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Surface-modified nanoparticles
US8802394B2 (en)	2008-11-13	2014-08-12	Radu O. Minea	Method of expressing proteins with disulfide bridges with enhanced yields and activity
EP2210584A1 (en)	2009-01-27	2010-07-28	Bayer Schering Pharma Aktiengesellschaft	Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
KR20120140658A (ko)	2010-02-12	2012-12-31	파마사이언스 인크.	Ｉａｐｂｉｒ 도메인 결합 화합물
WO2013092998A1 (en)	2011-12-23	2013-06-27	Innate Pharma	Enzymatic conjugation of antibodies
WO2014009426A2 (en)	2012-07-13	2014-01-16	Innate Pharma	Screening of conjugated antibodies
EP3564259A3 (en)	2012-11-09	2020-02-12	Innate Pharma	Recognition tags for tgase-mediated conjugation
US10611824B2 (en)	2013-03-15	2020-04-07	Innate Pharma	Solid phase TGase-mediated conjugation of antibodies
EP3010547B1 (en)	2013-06-20	2021-04-21	Innate Pharma	Enzymatic conjugation of polypeptides
WO2014202775A1 (en)	2013-06-21	2014-12-24	Innate Pharma	Enzymatic conjugation of polypeptides
WO2019092148A1 (en)	2017-11-10	2019-05-16	Innate Pharma	Antibodies with functionalized glutamine residues
GB202309910D0 (en) *	2023-06-29	2023-08-16	Implexion Pharma Ab	Therpay

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2685521B2 (ja)	1988-08-05	1997-12-03	株式会社日立製作所	車両用換気装置
EP0353732A3 (de) *	1988-08-05	1991-11-06	Ciba-Geigy Ag	Neue Fluorolefine, Verfahren zu deren Herstellung und deren Verwendung
AU624034B2 (en) *	1989-12-27	1992-05-28	Monsanto Company	Substituted pyridine compounds
US6441186B1 (en) *	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
US7407975B2 (en) *	1997-08-09	2008-08-05	Bayer Schering Pharma Ag	Epothilone derivatives, method for producing same and their pharmaceutical use
AU5036999A (en) *	1998-06-30	2000-01-17	Schering Aktiengesellschaft	Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
DE10020517A1 (de) *	2000-04-19	2001-10-25	Schering Ag	Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung

2000
- 2000-02-18 DE DE50014587T patent/DE50014587D1/de not_active Expired - Fee Related
- 2000-02-18 CZ CZ20012951A patent/CZ20012951A3/cs unknown
- 2000-02-18 ES ES00909205T patent/ES2291194T3/es not_active Expired - Lifetime
- 2000-02-18 SK SK1185-2001A patent/SK11852001A3/sk unknown
- 2000-02-18 EA EA200100826A patent/EA009206B1/ru unknown
- 2000-02-18 AU AU31567/00A patent/AU3156700A/en not_active Abandoned
- 2000-02-18 PL PL00349863A patent/PL349863A1/xx not_active Application Discontinuation
- 2000-02-18 BR BR0008331-3A patent/BR0008331A/pt not_active Application Discontinuation
- 2000-02-18 YU YU59001A patent/YU59001A/sh unknown
- 2000-02-18 NZ NZ513268A patent/NZ513268A/en unknown
- 2000-02-18 EP EP00909205A patent/EP1150980B1/de not_active Expired - Lifetime
- 2000-02-18 HR HR20010677A patent/HRP20010677A2/hr not_active Application Discontinuation
- 2000-02-18 WO PCT/EP2000/001333 patent/WO2000049021A2/de not_active Ceased
- 2000-02-18 CA CA002361278A patent/CA2361278A1/en not_active Abandoned
- 2000-02-18 HU HU0105478A patent/HUP0105478A3/hu unknown
- 2000-02-18 JP JP2000599760A patent/JP2002537301A/ja active Pending
- 2000-02-18 AT AT00909205T patent/ATE370946T1/de not_active IP Right Cessation
- 2000-02-18 US US09/913,495 patent/US6610736B1/en not_active Expired - Fee Related
- 2000-02-18 EE EEP200100431A patent/EE200100431A/xx unknown
- 2000-02-18 CN CNB008039763A patent/CN1209360C/zh not_active Expired - Fee Related
- 2000-02-18 KR KR1020017010455A patent/KR100718616B1/ko not_active Expired - Fee Related
- 2000-02-18 IL IL14451900A patent/IL144519A0/xx unknown
- 2000-02-18 MX MXPA01008328A patent/MXPA01008328A/es active IP Right Grant
- 2000-02-21 AR ARP000100714A patent/AR022636A1/es unknown
- 2000-04-19 TW TW089102834A patent/TWI285645B/zh not_active IP Right Cessation
2001
- 2001-08-09 BG BG105802A patent/BG105802A/bg unknown
- 2001-08-17 NO NO20014013A patent/NO20014013L/no not_active Application Discontinuation
2003
- 2003-02-12 US US10/364,337 patent/US6930102B2/en not_active Expired - Fee Related
2005
- 2005-03-25 US US11/090,841 patent/US20050187270A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE50014587D1 (de)	2007-10-04
KR20010102215A (ko)	2001-11-15
AU3156700A (en)	2000-09-04
EP1150980A2 (de)	2001-11-07
HK1044945A1 (en)	2002-11-08
NO20014013D0 (no)	2001-08-17
MXPA01008328A (es)	2002-06-04
IL144519A0 (en)	2002-05-23
YU59001A (sh)	2005-07-19
HUP0105478A2 (en)	2002-06-29
EA009206B1 (ru)	2007-12-28
TWI285645B (en)	2007-08-21
ES2291194T3 (es)	2008-03-01
CN1209360C (zh)	2005-07-06
ATE370946T1 (de)	2007-09-15
SK11852001A3 (sk)	2002-04-04
BR0008331A (pt)	2002-01-29
US6610736B1 (en)	2003-08-26
US20040014978A1 (en)	2004-01-22
WO2000049021A2 (de)	2000-08-24
BG105802A (bg)	2002-03-29
EA200100826A1 (ru)	2002-02-28
CA2361278A1 (en)	2000-08-24
JP2002537301A (ja)	2002-11-05
US6930102B2 (en)	2005-08-16
EP1150980B1 (de)	2007-08-22
HUP0105478A3 (en)	2002-08-28
US20050187270A1 (en)	2005-08-25
PL349863A1 (en)	2002-09-23
WO2000049021A3 (de)	2000-12-28
NO20014013L (no)	2001-10-18
KR100718616B1 (ko)	2007-05-16
AR022636A1 (es)	2002-09-04
NZ513268A (en)	2004-05-28
CZ20012951A3 (cs)	2001-11-14
HRP20010677A2 (en)	2005-06-30
CN1341115A (zh)	2002-03-20

Publication	Publication Date	Title
EE200100431A (et)	2002-12-16	16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
EE200200095A (et)	2003-04-15	Sulfonüülkarboksamiidi derivaadid, nende kasutamine, ravim ja nende valmistamismeetod
EE04464B1 (et)	2005-04-15	Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE04915B1 (et)	2007-10-15	Kinuklidiinderivaadid, nende valmistamismeetod, vahehendid, farmatseutiline kompositsioon ja nende kasutamine
EE04275B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid
EE200200487A (et)	2004-02-16	Asetidiini derivaadid, nende valmistamismeetodid ja farmatseutiline kompositsioon
EE04565B1 (et)	2005-12-15	Adamantaani derivaadid, nende saamine ja kasutamine
FI955913A0 (fi)	1995-12-08	Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
NO20001409D0 (no)	2000-03-17	Karboksamidotiazolderivater, fremgangsmåte for fremstilling derav og farmasøytiske blandinger
EE200300327A (et)	2003-10-15	Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon
EE200300369A (et)	2003-10-15	Atsüülitud indanüülamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat
EE200300581A (et)	2004-02-16	Karboksamiid-asendatud fenüüluurea derivaadid ja nende kasutamine, ravim ja selle valmistamismeetod
EE05109B1 (et)	2008-12-15	Sulfoonamiidi derivaadid, nende kasutamine meditsiinis ning meetod nende valmistamiseks
EE200300245A (et)	2003-08-15	Bensotiofeeni derivaadid, nende valmistamise meetod ja kasutamine
EE200100470A (et)	2002-12-16	Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine
NO20016038D0 (no)	2001-12-10	Benzenderivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
EE04151B1 (et)	2003-10-15	Atsüülpiperasinüülpürimidiinide derivaadid, nendevalmistamine ja kasutamine ravimitena
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
EE200100422A (et)	2002-12-16	Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine
EE9900112A (et)	1999-10-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
NO20022021D0 (no)	2002-04-29	Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidler
EE04346B1 (et)	2004-08-16	Asoolid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE04683B1 (et)	2006-08-15	A-grupi streptogramiinide derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon
EE04902B1 (et)	2007-10-15	Mikrograanul, selle valmistamismeetod ja farmatseutiline preparaat