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NO20013900L - Epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem - Google Patents

Epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem

Info

Publication number
NO20013900L
NO20013900L NO20013900A NO20013900A NO20013900L NO 20013900 L NO20013900 L NO 20013900L NO 20013900 A NO20013900 A NO 20013900A NO 20013900 A NO20013900 A NO 20013900A NO 20013900 L NO20013900 L NO 20013900L
Authority
NO
Norway
Prior art keywords
processes
preparation
pharmaceutical use
epothilone derivatives
epothilone
Prior art date
Application number
NO20013900A
Other languages
English (en)
Other versions
NO20013900D0 (no
Inventor
Ulrich Klar
Werner Skuballa
Bernd Buchmann
Wolfgang Schwede
Michael Schirner
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107480 external-priority patent/DE19907480A1/de
Priority claimed from DE19954229A external-priority patent/DE19954229A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20013900D0 publication Critical patent/NO20013900D0/no
Publication of NO20013900L publication Critical patent/NO20013900L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20013900A 1999-02-11 2001-08-10 Epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem NO20013900L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107480 DE19907480A1 (de) 1999-02-11 1999-02-11 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229A DE19954229A1 (de) 1999-11-04 1999-11-04 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001104 WO2000047584A2 (de) 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Publications (2)

Publication Number Publication Date
NO20013900D0 NO20013900D0 (no) 2001-08-10
NO20013900L true NO20013900L (no) 2001-10-11

Family

ID=26051977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013900A NO20013900L (no) 1999-02-11 2001-08-10 Epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem

Country Status (21)

Country Link
US (2) US7001916B1 (no)
EP (1) EP1161430A2 (no)
JP (1) JP2002536450A (no)
KR (1) KR20010094763A (no)
CN (1) CN1340053A (no)
AU (1) AU4101800A (no)
BG (1) BG105803A (no)
BR (1) BR0008206A (no)
CA (1) CA2360952A1 (no)
CZ (1) CZ20012886A3 (no)
EA (1) EA200100833A1 (no)
EE (1) EE200100422A (no)
HK (1) HK1044946A1 (no)
HU (1) HUP0105330A2 (no)
IL (1) IL144370A0 (no)
MX (1) MXPA01008148A (no)
NO (1) NO20013900L (no)
PL (1) PL350190A1 (no)
SK (1) SK11452001A3 (no)
WO (1) WO2000047584A2 (no)
YU (1) YU57601A (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
US7125893B1 (en) * 1999-04-30 2006-10-24 Schering Ag 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
US7723339B2 (en) * 2001-02-27 2010-05-25 Novartis Ag Combination comprising a signal transduction inhibitor and an epothilone derivative
ES2315399T3 (es) * 2001-08-23 2009-04-01 Novartis Ag Analogos de epotilona ciclobutilo y ciclopropilo.
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
RU2379032C9 (ru) * 2002-06-10 2010-03-27 Новартис Аг Комбинации, включающие эпотилоны, и их фармацевтическое применение
CN101816792A (zh) * 2002-06-10 2010-09-01 诺瓦提斯公司 包含埃坡霉素的组合及其药学用途
CA2494536C (en) * 2002-07-31 2011-10-04 Mercian Corporation A 12-membered ring macrolide active substance
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1589011A1 (en) * 2004-04-22 2005-10-26 Schering Aktiengesellschaft Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation
EP1856255A4 (en) 2005-02-11 2010-01-27 Univ Southern California PROCESS FOR EXPRESSING PROTEINS VIA DISULPHIDE BRIDGES
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
US20100113128A1 (en) * 2008-11-05 2010-05-06 Snow Richard N Methods and apparatus for determining a reel strip position
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
JP5881254B2 (ja) 2010-05-18 2016-03-09 セルリアン・ファーマ・インコーポレイテッド 自己免疫疾患およびその他の疾患の治療のための組成物および方法
WO2017066606A1 (en) 2015-10-16 2017-04-20 William Marsh Rice University Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
WO2017096559A1 (en) * 2015-12-09 2017-06-15 Rhodia Operations Production of xylene derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5469145A (en) 1992-05-29 1995-11-21 Johnson; Lonnie Wet diaper detector
DK0873341T3 (da) 1995-11-17 2004-01-19 Biotechnolog Forschung Gmbh Epothilonderivater, fremstilling og anvendelse
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
JP2001500851A (ja) 1996-08-30 2001-01-23 ノバルティス アクチエンゲゼルシャフト エポシロンの製造法および製造過程中に得られる中間生産物
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
WO1999001124A1 (en) * 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
CA2299608A1 (en) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft New epothilone derivatives, method for producing same and their pharmaceutical use
AU4775299A (en) 1998-06-22 2000-01-10 Nicolaou, Kyriacos Costa Desmethyl epothilones
WO2001066154A2 (de) 2000-03-09 2001-09-13 Klar, Ulrich Radioaktiv markierte epothilon-derivate, verfahren zu deren herstellung und ihre biochemische und pharmazeutische verwendung
CA2359267A1 (en) 2000-10-19 2002-04-19 Manabu Takami Wavelength selecting module and wavelength selecting apparatus
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
KR20050026033A (ko) * 2002-07-31 2005-03-14 쉐링 악티엔게젤샤프트 신규 효과기 접합체, 그의 제조 방법 및 그의 약학적 용도
WO2004015088A2 (en) 2002-08-13 2004-02-19 Kosan Biosciences, Inc. Transposon-based transformation system

Also Published As

Publication number Publication date
US20060040990A1 (en) 2006-02-23
PL350190A1 (en) 2002-11-18
SK11452001A3 (sk) 2002-04-04
WO2000047584A3 (de) 2000-12-28
BG105803A (en) 2002-03-29
KR20010094763A (ko) 2001-11-01
MXPA01008148A (es) 2003-07-21
EP1161430A2 (de) 2001-12-12
YU57601A (sh) 2005-06-10
CN1340053A (zh) 2002-03-13
AU4101800A (en) 2000-08-29
BR0008206A (pt) 2002-02-19
US7001916B1 (en) 2006-02-21
CA2360952A1 (en) 2000-08-17
IL144370A0 (en) 2002-05-23
CZ20012886A3 (cs) 2001-11-14
JP2002536450A (ja) 2002-10-29
HUP0105330A2 (hu) 2002-05-29
NO20013900D0 (no) 2001-08-10
EE200100422A (et) 2002-12-16
EA200100833A1 (ru) 2002-02-28
HK1044946A1 (zh) 2002-11-08
WO2000047584A2 (de) 2000-08-17

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application