NO20000700L - Interleukin-18-proteiner samt fremstilling og anvendelse derav - Google Patents

Interleukin-18-proteiner samt fremstilling og anvendelse derav

Info

Publication number: NO20000700L
Authority: NO; Norway
Prior art keywords: interleukin; proteins; preparation
Prior art date: 1997-08-14

Application number

NO20000700A

Other languages

English (en)

Other versions

NO327240B1 (no

NO20000700D0 (no

Inventor

Daniela Novick

Charles Dinarello

Menachem Rubinstein

Soo Hyun Kim

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-14

Filing date

2000-02-11

Publication date

2000-04-14

1997-08-14 Priority claimed from IL12155497A external-priority patent/IL121554A0/xx

1997-08-27 Priority claimed from IL12163997A external-priority patent/IL121639A0/xx

2000-02-11 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2000-02-11 Publication of NO20000700D0 publication Critical patent/NO20000700D0/no

2000-04-14 Publication of NO20000700L publication Critical patent/NO20000700L/no

2009-05-18 Publication of NO327240B1 publication Critical patent/NO327240B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Cell Biology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)

NO20000700A 1997-08-14 2000-02-11 Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter. NO327240B1 (no)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
IL12155497A IL121554A0 (en)	1997-08-14	1997-08-14	Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en)	1997-08-14	1997-08-27	Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en)	1997-08-14	1997-09-29	Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en)	1997-08-14	1997-11-06	Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en)	1997-08-14	1998-07-22	Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en)	1997-08-14	1998-08-13	Interleukin-18 binding proteins, their preparation and use

Publications (3)

Publication Number	Publication Date
NO20000700D0 NO20000700D0 (no)	2000-02-11
NO20000700L true NO20000700L (no)	2000-04-14
NO327240B1 NO327240B1 (no)	2009-05-18

Family

ID=27517687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000700A NO327240B1 (no)	1997-08-14	2000-02-11	Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter.

Country Status (28)

Country	Link
US (4)	US6605280B1 (no)
EP (1)	EP1003781B1 (no)
JP (1)	JP4272348B2 (no)
KR (1)	KR100687388B1 (no)
CN (1)	CN1243021C (no)
AR (2)	AR013422A1 (no)
AT (1)	ATE443719T1 (no)
AU (1)	AU755794B2 (no)
BG (1)	BG65519B1 (no)
BR (1)	BRPI9811940B8 (no)
CA (1)	CA2298855C (no)
CY (1)	CY1109664T1 (no)
CZ (1)	CZ300818B6 (no)
DE (2)	DE1003781T1 (no)
DK (1)	DK1003781T3 (no)
EA (1)	EA003675B1 (no)
EE (1)	EE05538B1 (no)
ES (1)	ES2149149T3 (no)
HU (1)	HU226698B1 (no)
IL (5)	IL121860A0 (no)
NO (1)	NO327240B1 (no)
NZ (1)	NZ502392A (no)
PL (1)	PL206070B1 (no)
PT (1)	PT1003781E (no)
SI (1)	SI1003781T1 (no)
SK (1)	SK287194B6 (no)
UA (1)	UA75862C2 (no)
WO (1)	WO1999009063A1 (no)

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AU2001236807A1 (en) *	2000-02-10	2001-08-20	Abbott Laboratories	Antibodies that bind human interleukin-18 and methods of making and using
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PL376536A1 (pl)	2002-08-28	2006-01-09	Immunex Corporation	Kompozycje i sposoby leczenia chorób układu sercowo-naczyniowego
MXPA05003869A (es) *	2002-10-08	2005-06-22	Ares Trading Sa	El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina.
IL152232A0 (en) *	2002-10-10	2003-05-29	Yeda Res & Dev	Promoter to il-18bp, its preparation and use
CN100457901C (zh) *	2003-04-30	2009-02-04	独立行政法人科学技术振兴机构	人抗人白介素-18抗体及其片断和它们的利用方法
ATE549353T1 (de)	2003-05-13	2012-03-15	Merck Serono Sa	Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
ATE360647T1 (de)	2003-11-05	2007-05-15	Ares Trading Sa	Verfahren zur aufreinigung von il-18-bindendem protein
CA2545359C (en) *	2003-11-12	2012-11-06	The Regents Of The University Of Colorado, A Body Corporate	Compositions and methods for regulation of tumor necrosis factor-alpha
US20050100965A1 (en) *	2003-11-12	2005-05-12	Tariq Ghayur	IL-18 binding proteins
US7968684B2 (en) *	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
IL159670A0 (en) *	2003-12-31	2004-06-01	Yeda Res & Dev	Use of il-18 binding protein in inflammations
ATE375385T1 (de) *	2004-03-01	2007-10-15	Ares Trading Sa	Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2005097998A2 (en) *	2004-03-31	2005-10-20	Regeneron Pharmaceuticals, Inc.	Il-18 specific polypeptides and therapeutic uses thereof
US7439336B2 (en)	2004-06-29	2008-10-21	Ares Trading S.A.	Process for the purification of IL-18 binding protein
DK1888100T3 (da) *	2005-06-03	2012-01-23	Merck Serono Sa	Anvendelse af IL-18BP-isoformer til behandling og/eller forebyggelse af neurologiske inflammatoriske sygdomme
CA2609060C (en)	2005-06-03	2014-07-15	Urs Weber	Production of recombinant il-18 binding protein
ES2375831T3 (es) *	2005-06-10	2012-03-06	Ares Trading S.A.	Procedimiento para la purificación de prote�?nas de unión a il-18.
CN101003812B (zh) *	2006-01-17	2011-01-05	温州医学院	一种用于制备重组人egf-il18融合蛋白的方法
BRPI0711908B8 (pt)	2006-05-25	2021-05-25	Glaxo Group Ltd	anticorpo anti-interleucina-18 humanizado, composição farmacêutica, uso de um anticorpo anti-interleucina 18, e, método de produção de um anticorpo.
WO2010040736A2 (en) *	2008-10-07	2010-04-15	Ablynx Nv	Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
US20150352561A1 (en) *	2013-01-02	2015-12-10	Wilsa Holdings ,LLC	Method and Apparatus for Conditioning Fluids
PT3041864T (pt) *	2013-09-05	2021-10-26	Ab2 Bio Sa	Proteína de ligação a il-18 (il-18bp) em doenças inflamatórias
RU2755691C2 (ru)	2015-03-05	2021-09-20	Аб2 Био Са	Il-18-связывающие белок (il-18bp) и антитела при воспалительных заболеваниях
EP3943097A1 (en)	2020-07-24	2022-01-26	AB2 Bio SA	Car-t cell therapy
WO2023143535A1 (zh) *	2022-01-28	2023-08-03	和径医药科技（上海）有限公司	一种靶向il-18bp的抗体及其应用
IL314346A (en) *	2022-03-15	2024-09-01	Compugen Ltd	Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment
CN114605521A (zh) *	2022-04-06	2022-06-10	内蒙古农业大学	一种细胞免疫调节蛋白及其应用
CN114891125B (zh) *	2022-06-16	2023-04-11	广东医科大学	一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
JP2026503273A (ja)	2023-01-06	2026-01-28	ラッセン・セラピューティクス・インコーポレイテッド	抗ｉｌ－１８ｂｐ抗体
TW202515608A (zh)	2023-06-26	2025-04-16	以色列商坎布根有限公司	Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

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1997
- 1997-09-29 IL IL12186097A patent/IL121860A0/xx unknown
- 1997-11-06 IL IL12213497A patent/IL122134A0/xx unknown
1998
- 1998-07-22 IL IL12546398A patent/IL125463A0/xx unknown
- 1998-08-13 DE DE1003781T patent/DE1003781T1/de active Pending
- 1998-08-13 WO PCT/IL1998/000379 patent/WO1999009063A1/en not_active Ceased
- 1998-08-13 CN CNB988081342A patent/CN1243021C/zh not_active Expired - Lifetime
- 1998-08-13 PT PT98938877T patent/PT1003781E/pt unknown
- 1998-08-13 SI SI9830922T patent/SI1003781T1/sl unknown
- 1998-08-13 IL IL13452398A patent/IL134523A0/xx active IP Right Grant
- 1998-08-13 DE DE69841175T patent/DE69841175D1/de not_active Expired - Lifetime
- 1998-08-13 JP JP2000509740A patent/JP4272348B2/ja not_active Expired - Lifetime
- 1998-08-13 AT AT98938877T patent/ATE443719T1/de active
- 1998-08-13 DK DK98938877.2T patent/DK1003781T3/da active
- 1998-08-13 PL PL338647A patent/PL206070B1/pl unknown
- 1998-08-13 NZ NZ502392A patent/NZ502392A/xx not_active IP Right Cessation
- 1998-08-13 HU HU0003533A patent/HU226698B1/hu unknown
- 1998-08-13 EA EA200000216A patent/EA003675B1/ru not_active IP Right Cessation
- 1998-08-13 ES ES98938877T patent/ES2149149T3/es not_active Expired - Lifetime
- 1998-08-13 CZ CZ20000490A patent/CZ300818B6/cs not_active IP Right Cessation
- 1998-08-13 US US09/485,632 patent/US6605280B1/en not_active Expired - Lifetime
- 1998-08-13 EE EEP200000073A patent/EE05538B1/xx unknown
- 1998-08-13 CA CA2298855A patent/CA2298855C/en not_active Expired - Lifetime
- 1998-08-13 EP EP98938877A patent/EP1003781B1/en not_active Expired - Lifetime
- 1998-08-13 BR BRPI9811940 patent/BRPI9811940B8/pt not_active IP Right Cessation
- 1998-08-13 SK SK176-2000A patent/SK287194B6/sk not_active IP Right Cessation
- 1998-08-13 KR KR1020007001504A patent/KR100687388B1/ko not_active Expired - Lifetime
- 1998-08-13 AU AU87460/98A patent/AU755794B2/en not_active Expired
- 1998-08-13 UA UA2000031437A patent/UA75862C2/uk unknown
- 1998-08-14 AR ARP980104054A patent/AR013422A1/es active IP Right Grant
2000
- 2000-02-10 BG BG104149A patent/BG65519B1/bg unknown
- 2000-02-11 NO NO20000700A patent/NO327240B1/no not_active IP Right Cessation
- 2000-02-13 IL IL134523A patent/IL134523A/en not_active IP Right Cessation
2003
- 2003-05-08 US US10/434,583 patent/US7101689B2/en not_active Expired - Lifetime
2006
- 2006-03-15 US US11/376,794 patent/US7799541B2/en not_active Expired - Fee Related
2007
- 2007-09-17 AR ARP070104104A patent/AR062867A2/es not_active Application Discontinuation
2009
- 2009-07-29 US US12/511,756 patent/US8436148B2/en not_active Expired - Fee Related
- 2009-11-25 CY CY20091101232T patent/CY1109664T1/el unknown

Also Published As

Publication number	Publication date
DE1003781T1 (de)	2001-01-11
SK287194B6 (sk)	2010-03-08
US7799541B2 (en)	2010-09-21
IL125463A0 (en)	1999-03-12
NZ502392A (en)	2002-12-20
SI1003781T1 (sl)	2009-12-31
KR20010022900A (ko)	2001-03-26
US6605280B1 (en)	2003-08-12
IL134523A (en)	2011-09-27
AR062867A2 (es)	2008-12-10
HUP0003533A2 (hu)	2001-01-29
PT1003781E (pt)	2009-10-26
SK1762000A3 (en)	2000-09-12
JP4272348B2 (ja)	2009-06-03
EA200000216A1 (ru)	2000-08-28
CZ2000490A3 (cs)	2000-08-16
CY1109664T1 (el)	2014-08-13
ES2149149T1 (es)	2000-11-01
PL206070B1 (pl)	2010-06-30
CA2298855A1 (en)	1999-02-25
NO327240B1 (no)	2009-05-18
US20100010200A1 (en)	2010-01-14
KR100687388B1 (ko)	2007-02-26
ES2149149T3 (es)	2009-12-01
BG104149A (bg)	2000-08-31
IL121860A0 (en)	1998-02-22
BG65519B1 (bg)	2008-10-31
PL338647A1 (en)	2000-11-06
DK1003781T3 (da)	2010-01-25
EP1003781B1 (en)	2009-09-23
WO1999009063A1 (en)	1999-02-25
BRPI9811940B1 (pt)	2011-10-04
US8436148B2 (en)	2013-05-07
BRPI9811940A (pt)	2000-09-05
IL134523A0 (en)	2001-04-30
BRPI9811940B8 (pt)	2021-07-06
CA2298855C (en)	2014-05-27
NO20000700D0 (no)	2000-02-11
US20060154294A1 (en)	2006-07-13
HUP0003533A3 (en)	2003-08-28
AR013422A1 (es)	2000-12-27
ATE443719T1 (de)	2009-10-15
HK1028773A1 (en)	2001-03-02
IL122134A0 (en)	1998-04-05
JP2001514876A (ja)	2001-09-18
CZ300818B6 (cs)	2009-08-19
CN1267307A (zh)	2000-09-20
UA75862C2 (uk)	2006-06-15
DE69841175D1 (de)	2009-11-05
EP1003781A1 (en)	2000-05-31
US7101689B2 (en)	2006-09-05
AU755794B2 (en)	2002-12-19
EE200000073A (no)	2000-10-16
US20040037829A1 (en)	2004-02-26
CN1243021C (zh)	2006-02-22
AU8746098A (en)	1999-03-08
EE05538B1 (et)	2012-04-16
HU226698B1 (en)	2009-07-28
EA003675B1 (ru)	2003-08-28

Publication	Publication Date	Title
NO20000700L (no)	2000-04-14	Interleukin-18-proteiner samt fremstilling og anvendelse derav
NO983364D0 (no)	1998-07-21	Konsensusproteiner
IS5375A (is)	2000-02-11	KAY-nýstárlegt ónæmisprótín
IS4496A (is)	1997-06-04	Úðablöndur úr peptíðum og próteinum
NO20071415L (no)	1999-08-19	OB-fusjonsproteinpreparater og fremgangsmater
DE69839603D1 (de)	2008-07-24	Zierenden proteins
NO963371D0 (no)	1996-08-13	Hematopoeseprotein samt materialer og fremgangsmåter for fremstilling av det
ATE285788T1 (de)	2005-01-15	Aktiviertes protein c formulierungen
DK0921796T3 (da)	2001-07-16	Tetrahydrolipstatinholdige præparater
DE69735926D1 (de)	2006-06-29	Interleukin-18 Rezeptorproteine
NO20002990L (no)	2000-08-08	Nytt overflateprotein
DK0941056T3 (da)	2002-07-15	Sphingomyelinasepræparater samt anvendelse deraf
FI970979L (fi)	1997-03-07	Muokatut ihmisen C3-proteiinit
NO971505D0 (no)	1997-04-03	Trofinin og trofininhjelperproteiner
DE69705017D1 (de)	2001-07-05	Medikamente bindendes Protein
EP1018551A4 (en)	2003-07-23	MEGSIN PROTEIN
ID21034A (id)	1999-04-08	Protein kinase dan penggunaannya
DE69837507D1 (de)	2007-05-24	Humanes Hedgehog-Protein
NO20005547D0 (no)	2000-11-03	Myelinbasiske proteinpeptider og anvendelser derav
KR960010685A (ko)	1996-04-20	펩티드 및 그 용도
SE9701041D0 (sv)	1997-03-21	Novel proteins and their use
NO20006091D0 (no)	2000-11-30	Humant protein C-polypeptid
NO20002832D0 (no)	2000-06-02	Humantyroidprotein ZSig45 og DNA som koder for dette
IS8568A (is)	2006-11-14	Vatnsfælanlega umbreyttar prótínsamsetningar og aðferðir
DE69434900D1 (de)	2007-02-08	Menschliche chemokin-polypeptide

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2018-09-10	MK1K	Patent expired