EE05538B1 - Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine - Google Patents

Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine

Info

Publication number: EE05538B1
Authority: EE; Estonia
Prior art keywords: interleukin; preparation; binding proteins; proteins; binding
Prior art date: 1997-08-14

Application number

EEP200000073A

Other languages

English (en)

Estonian (et)

Inventor

Novick Daniela

Dinarello Charles

Rubinstein Menachem

Hyun Kim Soo

Original Assignee

Yeda Research And Development Co. Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-14

Filing date

1998-08-13

Publication date

2012-04-16

1997-08-14 Priority claimed from IL12155497A external-priority patent/IL121554A0/xx

1997-08-27 Priority claimed from IL12163997A external-priority patent/IL121639A0/xx

1998-08-13 Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.

2000-10-16 Publication of EE200000073A publication Critical patent/EE200000073A/xx

2012-04-16 Publication of EE05538B1 publication Critical patent/EE05538B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Neurology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Transplantation (AREA)

EEP200000073A 1997-08-14 1998-08-13 Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine EE05538B1 (et)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
IL12155497A IL121554A0 (en)	1997-08-14	1997-08-14	Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en)	1997-08-14	1997-08-27	Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en)	1997-08-14	1997-09-29	Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en)	1997-08-14	1997-11-06	Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en)	1997-08-14	1998-07-22	Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en)	1997-08-14	1998-08-13	Interleukin-18 binding proteins, their preparation and use

Publications (2)

Publication Number	Publication Date
EE200000073A EE200000073A (xx)	2000-10-16
EE05538B1 true EE05538B1 (et)	2012-04-16

Family

ID=27517687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000073A EE05538B1 (et)	1997-08-14	1998-08-13	Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine

Country Status (28)

Country	Link
US (4)	US6605280B1 (xx)
EP (1)	EP1003781B1 (xx)
JP (1)	JP4272348B2 (xx)
KR (1)	KR100687388B1 (xx)
CN (1)	CN1243021C (xx)
AR (2)	AR013422A1 (xx)
AT (1)	ATE443719T1 (xx)
AU (1)	AU755794B2 (xx)
BG (1)	BG65519B1 (xx)
BR (1)	BRPI9811940B8 (xx)
CA (1)	CA2298855C (xx)
CY (1)	CY1109664T1 (xx)
CZ (1)	CZ300818B6 (xx)
DE (2)	DE69841175D1 (xx)
DK (1)	DK1003781T3 (xx)
EA (1)	EA003675B1 (xx)
EE (1)	EE05538B1 (xx)
ES (1)	ES2149149T3 (xx)
HU (1)	HU226698B1 (xx)
IL (5)	IL121860A0 (xx)
NO (1)	NO327240B1 (xx)
NZ (1)	NZ502392A (xx)
PL (1)	PL206070B1 (xx)
PT (1)	PT1003781E (xx)
SI (1)	SI1003781T1 (xx)
SK (1)	SK287194B6 (xx)
UA (1)	UA75862C2 (xx)
WO (1)	WO1999009063A1 (xx)

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IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en)	1998-06-24	1999-12-24	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	An artificial peptide capable of neutralizing the biological activity of interleukin-18
CA2340579A1 (en) *	1998-09-01	2000-03-09	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Interleukin 18-binding protein
AR022952A1 (es) *	1999-03-19	2002-09-04	Smithkline Beecham Corp	ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
IL131047A0 (en) *	1999-07-22	2001-01-28	Yeda Res & Dev	Use of il-18 inhibitors
DE60041432D1 (de) *	1999-11-16	2009-03-12	Hayashibara Biochem Lab	Antikörper spezifisch für den Interleukin-18 Vorläufer
CN102206277A (zh) *	2000-02-10	2011-10-05	雅培制药有限公司	结合人白介素-18的抗体及制备和使用方法
KR20070087256A (ko) *	2000-02-21	2007-08-27	어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이.	Ｉｌ-18 저해물질의 용도
AU2005211606B2 (en) *	2000-05-05	2007-02-22	Inserm - Institut National De La Sante Et De La Recherche Medicale	Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
EA007014B1 (ru) *	2000-05-05	2006-06-30	Апплайд Резеч Системз Арс Холдинг Н.В.	Применение il-18 в качестве диагностического маркера
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US7718368B2 (en) *	2000-12-04	2010-05-18	Viron Therapeutics Inc.	Immunomodulatory protein and useful embodiments thereof
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JP2006508056A (ja)	2002-08-28	2006-03-09	イミュネックス・コーポレーション	心臓血管疾患を治療するための組成物および方法
EP1572291B1 (en) *	2002-10-08	2013-04-03	Ares Trading S.A.	The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine
IL152232A0 (en) *	2002-10-10	2003-05-29	Yeda Res & Dev	Promoter to il-18bp, its preparation and use
KR100988129B1 (ko)	2003-04-30	2010-10-18	쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트	인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법
US20080076708A1 (en) *	2003-05-13	2008-03-27	Valter Altarocca	Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
DK1689777T3 (da)	2003-11-05	2007-06-11	Ares Trading Sa	Fremgangsmåde til oprensning af il18-bindende protein
US7968684B2 (en)	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
BRPI0416467A (pt) *	2003-11-12	2007-03-06	Univ Colorado Regents	ácido nucléico purificado, célula hospedeira, proteìna purificada, anticorpo, fragmento fab, e, métodos para induzir a produção de tnf alfa, para tratar um paciente, e para triagem para inibidores da il-32
US20050100965A1 (en)	2003-11-12	2005-05-12	Tariq Ghayur	IL-18 binding proteins
IL159670A0 (en) *	2003-12-31	2004-06-01	Yeda Res & Dev	Use of il-18 binding protein in inflammations
DK1720979T3 (da) *	2004-03-01	2007-12-10	Ares Trading Sa	Anvendelse af et serumfrit celledyrkningsmedium til fremstilling af IL-18BP I pattedyrceller
WO2005097998A2 (en) *	2004-03-31	2005-10-20	Regeneron Pharmaceuticals, Inc.	Il-18 specific polypeptides and therapeutic uses thereof
DE602005009827D1 (de) *	2004-06-29	2008-10-30	Ares Trading Sa	Verfahren zur aufreinigung von il-18-bindendem protein
SI1888100T1 (sl) *	2005-06-03	2012-01-31	Merck Serono Sa	Uporaba izooblik il-18pb za zdravljenje in/ali prepreäśevanje nevroloĺ kih vnetnih bolezni
PL1885753T3 (pl) *	2005-06-03	2011-12-30	Ares Trading Sa	Wytwarzanie rekombinowanego białka wiążącego IL-18
ATE529433T1 (de) *	2005-06-10	2011-11-15	Ares Trading Sa	Verfahren zur reinigung eines il-18-bindenden proteins
CN101003812B (zh) *	2006-01-17	2011-01-05	温州医学院	一种用于制备重组人egf-il18融合蛋白的方法
CA2652733C (en)	2006-05-25	2016-06-21	Glaxo Group Limited	Modified humanised anti-interleukin-18 antibodies
WO2010040736A2 (en) *	2008-10-07	2010-04-15	Ablynx Nv	Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
CA2897067A1 (en) *	2013-01-02	2014-07-10	Wilsa, Inc.	Method and apparatus for conditioning fluids
KR102321172B1 (ko) *	2013-09-05	2021-11-05	에이비2 바이오 에스에이	염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ)
CA2972689A1 (en)	2015-03-05	2016-09-09	Ab2 Bio Sa	Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
EP3943097A1 (en)	2020-07-24	2022-01-26	AB2 Bio SA	Car-t cell therapy
CN120737196A (zh) *	2022-01-28	2025-10-03	和径医药科技（上海）有限公司	一种靶向il-18bp的抗体及其应用
IL314346A (en) *	2022-03-15	2024-09-01	Compugen Ltd	Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment
CN114605521A (zh) *	2022-04-06	2022-06-10	内蒙古农业大学	一种细胞免疫调节蛋白及其应用
CN114891125B (zh) *	2022-06-16	2023-04-11	广东医科大学	一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
KR20250133728A (ko)	2023-01-06	2025-09-08	라센 테라퓨틱스, 인코포레이티드	항-il-18bp 항체
TW202515608A (zh)	2023-06-26	2025-04-16	以色列商坎布根有限公司	Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

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1997
- 1997-09-29 IL IL12186097A patent/IL121860A0/xx unknown
- 1997-11-06 IL IL12213497A patent/IL122134A0/xx unknown
1998
- 1998-07-22 IL IL12546398A patent/IL125463A0/xx unknown
- 1998-08-13 AU AU87460/98A patent/AU755794B2/en not_active Expired
- 1998-08-13 DK DK98938877.2T patent/DK1003781T3/da active
- 1998-08-13 ES ES98938877T patent/ES2149149T3/es not_active Expired - Lifetime
- 1998-08-13 WO PCT/IL1998/000379 patent/WO1999009063A1/en not_active Ceased
- 1998-08-13 NZ NZ502392A patent/NZ502392A/xx not_active IP Right Cessation
- 1998-08-13 EE EEP200000073A patent/EE05538B1/xx unknown
- 1998-08-13 JP JP2000509740A patent/JP4272348B2/ja not_active Expired - Lifetime
- 1998-08-13 AT AT98938877T patent/ATE443719T1/de active
- 1998-08-13 CN CNB988081342A patent/CN1243021C/zh not_active Expired - Lifetime
- 1998-08-13 CZ CZ20000490A patent/CZ300818B6/cs not_active IP Right Cessation
- 1998-08-13 US US09/485,632 patent/US6605280B1/en not_active Expired - Lifetime
- 1998-08-13 UA UA2000031437A patent/UA75862C2/uk unknown
- 1998-08-13 PL PL338647A patent/PL206070B1/pl unknown
- 1998-08-13 CA CA2298855A patent/CA2298855C/en not_active Expired - Lifetime
- 1998-08-13 IL IL13452398A patent/IL134523A0/xx active IP Right Grant
- 1998-08-13 DE DE69841175T patent/DE69841175D1/de not_active Expired - Lifetime
- 1998-08-13 EA EA200000216A patent/EA003675B1/ru not_active IP Right Cessation
- 1998-08-13 SI SI9830922T patent/SI1003781T1/sl unknown
- 1998-08-13 BR BRPI9811940 patent/BRPI9811940B8/pt not_active IP Right Cessation
- 1998-08-13 HU HU0003533A patent/HU226698B1/hu unknown
- 1998-08-13 KR KR1020007001504A patent/KR100687388B1/ko not_active Expired - Lifetime
- 1998-08-13 PT PT98938877T patent/PT1003781E/pt unknown
- 1998-08-13 EP EP98938877A patent/EP1003781B1/en not_active Expired - Lifetime
- 1998-08-13 SK SK176-2000A patent/SK287194B6/sk not_active IP Right Cessation
- 1998-08-13 DE DE1003781T patent/DE1003781T1/de active Pending
- 1998-08-14 AR ARP980104054A patent/AR013422A1/es active IP Right Grant
2000
- 2000-02-10 BG BG104149A patent/BG65519B1/bg unknown
- 2000-02-11 NO NO20000700A patent/NO327240B1/no not_active IP Right Cessation
- 2000-02-13 IL IL134523A patent/IL134523A/en not_active IP Right Cessation
2003
- 2003-05-08 US US10/434,583 patent/US7101689B2/en not_active Expired - Lifetime
2006
- 2006-03-15 US US11/376,794 patent/US7799541B2/en not_active Expired - Fee Related
2007
- 2007-09-17 AR ARP070104104A patent/AR062867A2/es not_active Application Discontinuation
2009
- 2009-07-29 US US12/511,756 patent/US8436148B2/en not_active Expired - Fee Related
- 2009-11-25 CY CY20091101232T patent/CY1109664T1/el unknown

Also Published As

Publication number	Publication date
AR013422A1 (es)	2000-12-27
BG104149A (bg)	2000-08-31
SK287194B6 (sk)	2010-03-08
CA2298855C (en)	2014-05-27
KR20010022900A (ko)	2001-03-26
BRPI9811940B1 (pt)	2011-10-04
CY1109664T1 (el)	2014-08-13
US6605280B1 (en)	2003-08-12
IL134523A0 (en)	2001-04-30
ES2149149T1 (es)	2000-11-01
ES2149149T3 (es)	2009-12-01
WO1999009063A1 (en)	1999-02-25
US20100010200A1 (en)	2010-01-14
CN1243021C (zh)	2006-02-22
EA200000216A1 (ru)	2000-08-28
US7101689B2 (en)	2006-09-05
IL134523A (en)	2011-09-27
EE200000073A (xx)	2000-10-16
HU226698B1 (en)	2009-07-28
BG65519B1 (bg)	2008-10-31
BRPI9811940B8 (pt)	2021-07-06
US20040037829A1 (en)	2004-02-26
NO327240B1 (no)	2009-05-18
CN1267307A (zh)	2000-09-20
PT1003781E (pt)	2009-10-26
PL206070B1 (pl)	2010-06-30
KR100687388B1 (ko)	2007-02-26
IL121860A0 (en)	1998-02-22
DE1003781T1 (de)	2001-01-11
JP4272348B2 (ja)	2009-06-03
AR062867A2 (es)	2008-12-10
HUP0003533A2 (hu)	2001-01-29
EA003675B1 (ru)	2003-08-28
IL122134A0 (en)	1998-04-05
PL338647A1 (en)	2000-11-06
US7799541B2 (en)	2010-09-21
EP1003781B1 (en)	2009-09-23
IL125463A0 (en)	1999-03-12
US8436148B2 (en)	2013-05-07
AU8746098A (en)	1999-03-08
BRPI9811940A (pt)	2000-09-05
US20060154294A1 (en)	2006-07-13
UA75862C2 (uk)	2006-06-15
NZ502392A (en)	2002-12-20
SK1762000A3 (en)	2000-09-12
ATE443719T1 (de)	2009-10-15
NO20000700L (no)	2000-04-14
AU755794B2 (en)	2002-12-19
DE69841175D1 (de)	2009-11-05
CZ2000490A3 (cs)	2000-08-16
CA2298855A1 (en)	1999-02-25
EP1003781A1 (en)	2000-05-31
JP2001514876A (ja)	2001-09-18
DK1003781T3 (da)	2010-01-25
HUP0003533A3 (en)	2003-08-28
NO20000700D0 (no)	2000-02-11
CZ300818B6 (cs)	2009-08-19
SI1003781T1 (sl)	2009-12-31
HK1028773A1 (en)	2001-03-02

Publication	Publication Date	Title
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FI964311L (fi)	1996-10-25	Bifunktionaalinen proteiini, valmistus ja käyttö
NO983364D0 (no)	1998-07-21	Konsensusproteiner
ATA1198A (de)	2002-02-15	Snowboard - einstiegsbindung
DE69828330D1 (de)	2005-02-03	Aktiviertes Protein C Formulierungen
ATA144897A (de)	1998-11-15	Wirbelsäulen-prothese
EP1110969A4 (en)	2002-01-09	INTERLEUKIN 18-BINDING PROTEINS
DE69705017D1 (de)	2001-07-05	Medikamente bindendes Protein
NO995062D0 (no)	1999-10-15	<Beta>-anyloidpeptid-bindende proteiner og polynuldeotider som kodes for samme
EP1018551A4 (en)	2003-07-23	MEGSIN PROTEIN
ATE262917T1 (de)	2004-04-15	Präparation umfassend thiolgruppen-haltige proteine
TR199701666A3 (tr)	1999-10-21	Sismanliga karsi proteinler
FI950516L (fi)	1995-08-08	Interferoni-alfa/beta-sitojaproteiini, sen valmistus ja käyttö
FI972965A7 (fi)	1997-07-11	Uusia peptidejä, niiden valmistus ja käyttö
EE200000018A (et)	2000-08-15	6-pürrolidiin-2-üülpüridiinid, nende valmistamine ja terapeutiline kasutamine
EE9900092A (et)	1999-10-15	PTX-tundlikud G-valgud, nende valmistamine ja kasutamine
FI971872A0 (fi)	1997-04-30	Proteiinikoostumus ja sen valmistus ja käyttö sekä sitä sisältävät valmisteet ja näiden valmistus
FI971086L (fi)	1997-03-14	Kinaasia sitova proteiini ja sen käyttö
AU1320600A (en)	2000-05-08	Human rna binding proteins
AU2003200442A1 (en)	2003-04-10	Interleukin-18 binding proteins, their preparation and use
ZA987310B (en)	2000-08-14	Interleukin-18 binding proteins, their preparation and use.
EP1030859A4 (en)	2002-10-30	RAS FIXING PROTEIN (PRE1)
IL121639A0 (en)	1998-02-08	Interleukin-18 binding proteins their preparation and use
SE9701041D0 (sv)	1997-03-21	Novel proteins and their use
NO981089D0 (no)	1998-03-12	Epoksy-azetidinoner, fremstilling og anvendelse derav