NO162819C - Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater.

Info

Publication number: NO162819C
Authority: NO; Norway
Prior art keywords: phenyledic; preparation; acetic acid; acid derivatives; therapeutic active
Prior art date: 1983-12-30

Application number

NO845282A

Other languages

English (en)

Norwegian (no)

Other versions

NO845282L (no

NO162819B (no

Inventor

Wolfgang Grell

Rudolf Hurnaus

Gerhart Griss

Robert Sauter

Eckhard Rupprecht

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-30

Filing date

1984-12-28

Publication date

1990-02-21

1984-12-28 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1985-07-01 Publication of NO845282L publication Critical patent/NO845282L/no

1989-11-13 Publication of NO162819B publication Critical patent/NO162819B/no

1990-02-21 Publication of NO162819C publication Critical patent/NO162819C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Lubricants (AREA)
Glass Compositions (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)

NO845282A 1983-12-30 1984-12-28 Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater. NO162819C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19833347565 DE3347565A1 (de)	1983-12-30	1983-12-30	Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19853522604 DE3522604A1 (de)	1983-12-30	1985-06-25	Neue feste formen von 2-(gamma)thoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl)-benzoesaeure, diese formen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number	Publication Date
NO845282L NO845282L (no)	1985-07-01
NO162819B NO162819B (no)	1989-11-13
NO162819C true NO162819C (no)	1990-02-21

Family

ID=37847099

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO845282A NO162819C (no)	1983-12-30	1984-12-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater.
NO862532A NO168302C (no)	1983-12-30	1986-06-24	Fremgangsmaate for fremstilling av krystallform (b) av 2-etoksy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1-butyl)-aminokarbonylmetyl)-benzoesyre
NO1999016C NO1999016I1 (no)	1983-12-30	1999-07-20	Repaglinid

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO862532A NO168302C (no)	1983-12-30	1986-06-24	Fremgangsmaate for fremstilling av krystallform (b) av 2-etoksy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1-butyl)-aminokarbonylmetyl)-benzoesyre
NO1999016C NO1999016I1 (no)	1983-12-30	1999-07-20	Repaglinid

Country Status (26)

Country	Link
EP (2)	EP0147850B1 (fr)
JP (2)	JPH0623200B2 (fr)
KR (1)	KR900005320B1 (fr)
AT (1)	ATE44027T1 (fr)
AU (2)	AU577815B2 (fr)
BG (1)	BG61519B2 (fr)
CA (2)	CA1225398A (fr)
CS (1)	CS409791A3 (fr)
DD (1)	DD231348A5 (fr)
DE (4)	DE3347565A1 (fr)
DK (2)	DK167439B1 (fr)
ES (7)	ES8605500A1 (fr)
FI (2)	FI80447C (fr)
GR (2)	GR82614B (fr)
HK (1)	HK87492A (fr)
HU (1)	HU194548B (fr)
IE (1)	IE57700B1 (fr)
IL (2)	IL73963A (fr)
LU (1)	LU90301I2 (fr)
MX (1)	MX9202772A (fr)
NL (1)	NL980034I1 (fr)
NO (3)	NO162819C (fr)
NZ (2)	NZ210657A (fr)
PT (2)	PT79772B (fr)
SG (1)	SG55492G (fr)
ZA (2)	ZA8410103B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3347565A1 (de) *	1983-12-30	1985-07-11	Thomae Gmbh Dr K	Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3523466A1 (de) *	1985-07-01	1987-01-08	Thomae Gmbh Dr K	Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE223391T1 (de) *	1991-06-21	2002-09-15	Boehringer Ingelheim Pharma	Verfahren zur herstellung von (s)-3-methyl-1-(2- piperidino-phenyl)-1-butylamin
DE10075006I2 (de) *	1991-06-21	2004-01-08	Boehringer Ingelheim Pharma	Verwendung von (S)(+)-2-Äthoxy-4-[N-[1-(2-Piperidino-Phenyl)-3-Methyl-1-Butyl[Aminocarbonylmethyl]-Benzoesäure zur Herstellung eines Langzeitantidiabetikums.
FR2763590B1 (fr) *	1997-05-22	2000-03-24	Synthelabo	Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
EP1741447B1 (fr)	2000-01-21	2013-09-18	Novartis AG	Combinaisons à base d'inhibiteurs de DPP-IV et d'antidiabetiques
WO2004018442A1 (fr) *	2002-08-23	2004-03-04	Dr. Reddy's Laboratories Limited	Formes cristalline et amorphe de (s)-repaglinide et procedes de preparation
WO2004101540A2 (fr) *	2003-05-14	2004-11-25	Cilag Ag	Procede de production de derives d'acide phenylacetique
WO2004103983A1 (fr) *	2003-05-26	2004-12-02	Biocon Limited	Procede de preparation de derives d'acide benzoique s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]
CA2526506A1 (fr) *	2003-06-09	2004-12-16	Boehringer Ingelheim International Gmbh	Inhibiteurs du papillomavirus
FR2875805B1 (fr) *	2004-09-27	2006-12-29	Genfit S A	Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
CN1305863C (zh) *	2004-12-27	2007-03-21	浙江大学	(s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
EP1931350B2 (fr)	2005-09-14	2021-08-04	Takeda Pharmaceutical Company Limited	Administration d'inhibiteurs de dipeptidyl peptidase
EP2177221A1 (fr)	2008-10-20	2010-04-21	Krka Tovarna Zdravil, D.D., Novo Mesto	Procedure de préparation de répaglinide essentielment optiquement pur et ses précurseurs
EP2430018B1 (fr)	2009-05-15	2013-07-03	Novartis AG	Dérivés de benzoxazolone en tant qu'inhibiteurs d'aldostérone synthase
SI2429995T1 (sl)	2009-05-15	2014-05-30	Novartis Ag	Arilpiridini kot inhibitorji aldosteron sintaze
JP5420761B2 (ja)	2009-05-28	2014-02-19	ノバルティスアーゲー	ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
MX2011012627A (es)	2009-05-28	2011-12-14	Novartis Ag	Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
WO2011041293A1 (fr)	2009-09-30	2011-04-07	Takeda Pharmaceutical Company Limited	Dérivés pyrazolo [1, 5a] pyrimidines comme inhibiteurs de kinase 1 régulatrice de signal d'apoptose
ES2551002T3 (es)	2009-11-17	2015-11-13	Novartis Ag	Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es)	2009-11-30	2014-07-01	Novartis Ag	Derivados de imidazol como inhibidores de aldosterona sintasa
CN102834393B (zh)	2010-02-03	2015-07-22	武田药品工业株式会社	细胞凋亡信号调节激酶1抑制剂
US8673974B2 (en)	2010-11-16	2014-03-18	Novartis Ag	Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012095548A2 (fr)	2011-01-13	2012-07-19	Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned)	Composés pour le traitement de maladies neurodégénératives
UY35144A (es)	2012-11-20	2014-06-30	Novartis Ag	Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
PE20151666A1 (es)	2013-02-14	2015-11-19	Novartis Ag	Derivados sustituidos del acido bisfenil butanoico fosfonico como inhibidores de la nep
PE20160991A1 (es)	2013-07-25	2016-10-15	Novartis Ag	Bioconjugados de polipeptidos de apelina sintetica
TW201536814A (zh)	2013-07-25	2015-10-01	Novartis Ag	用於治療心臟衰竭之合成環狀多肽
CA2972871A1 (fr)	2015-01-23	2016-07-28	Novartis Ag	Conjugues d'acides gras de l'apeline synthetique presentant une demi-vie amelioree
UY38072A (es)	2018-02-07	2019-10-01	Novartis Ag	Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3100575A1 (de) *	1981-01-10	1982-09-02	Dr. Karl Thomae Gmbh, 7950 Biberach	"neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
DE3100535A1 (de) *	1981-01-10	1982-08-12	Dr. Karl Thomae Gmbh, 7950 Biberach	"neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
SU1170969A3 (ru) *	1982-07-06	1985-07-30	Др.Карл Томэ,Гмбх (Фирма)	Способ получени производных фенилуксусной кислоты или их солей
FR2554875B1 (fr) *	1983-11-10	1986-02-28	Dba	Amplificateur hydraulique de freinage
DE3523466A1 (de) *	1985-07-01	1987-01-08	Thomae Gmbh Dr K	Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3347565A1 (de) *	1983-12-30	1985-07-11	Thomae Gmbh Dr K	Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

1983
- 1983-12-30 DE DE19833347565 patent/DE3347565A1/de not_active Withdrawn
1984
- 1984-12-20 NZ NZ210657A patent/NZ210657A/xx unknown
- 1984-12-20 DK DK613184A patent/DK167439B1/da active Protection Beyond IP Right Term
- 1984-12-24 JP JP59272685A patent/JPH0623200B2/ja not_active Expired - Lifetime
- 1984-12-27 DE DE8484116359T patent/DE3478682D1/de not_active Expired
- 1984-12-27 EP EP84116359A patent/EP0147850B1/fr not_active Expired
- 1984-12-27 DE DE1998175044 patent/DE19875044I2/de active Active
- 1984-12-27 ES ES539078A patent/ES8605500A1/es not_active Expired
- 1984-12-27 AT AT84116359T patent/ATE44027T1/de active
- 1984-12-28 KR KR1019840008504A patent/KR900005320B1/ko not_active Expired
- 1984-12-28 IL IL73963A patent/IL73963A/xx not_active IP Right Cessation
- 1984-12-28 CA CA000471120A patent/CA1225398A/fr not_active Expired
- 1984-12-28 HU HU844870A patent/HU194548B/hu unknown
- 1984-12-28 GR GR82614A patent/GR82614B/el unknown
- 1984-12-28 DD DD84272061A patent/DD231348A5/de not_active IP Right Cessation
- 1984-12-28 PT PT79772A patent/PT79772B/pt unknown
- 1984-12-28 NO NO845282A patent/NO162819C/no not_active IP Right Cessation
- 1984-12-28 IE IE3349/84A patent/IE57700B1/en not_active IP Right Cessation
- 1984-12-28 AU AU37210/84A patent/AU577815B2/en not_active Expired
- 1984-12-28 FI FI845145A patent/FI80447C/fi active IP Right Grant
- 1984-12-28 ZA ZA8410103A patent/ZA8410103B/xx unknown
1985
- 1985-06-25 DE DE19853522604 patent/DE3522604A1/de not_active Withdrawn
- 1985-08-05 ES ES545880A patent/ES8604545A1/es not_active Expired
- 1985-08-05 ES ES545883A patent/ES8604548A1/es not_active Expired
- 1985-08-05 ES ES545879A patent/ES8604544A1/es not_active Expired
- 1985-08-05 ES ES545881A patent/ES8604546A1/es not_active Expired
- 1985-08-05 ES ES545882A patent/ES8604547A1/es not_active Expired
1986
- 1986-06-10 EP EP86107890A patent/EP0207331B1/fr not_active Expired - Lifetime
- 1986-06-16 GR GR861558A patent/GR861558B/el unknown
- 1986-06-23 FI FI862650A patent/FI82689C/fi not_active IP Right Cessation
- 1986-06-24 NO NO862532A patent/NO168302C/no not_active IP Right Cessation
- 1986-06-24 PT PT82832A patent/PT82832B/pt unknown
- 1986-06-24 DK DK296686A patent/DK167573B1/da not_active IP Right Cessation
- 1986-06-24 ZA ZA864695A patent/ZA864695B/xx unknown
- 1986-06-24 CA CA000512269A patent/CA1292000C/fr not_active Expired - Lifetime
- 1986-06-24 IL IL79217A patent/IL79217A/xx not_active IP Right Cessation
- 1986-06-24 AU AU59139/86A patent/AU583631B2/en not_active Expired
- 1986-06-24 JP JP61148027A patent/JPH0739405B2/ja not_active Expired - Lifetime
- 1986-06-24 NZ NZ216640A patent/NZ216640A/xx unknown
- 1986-06-24 ES ES556495A patent/ES8802145A1/es not_active Expired
1991
- 1991-12-27 CS CS914097A patent/CS409791A3/cs unknown
1992
- 1992-05-25 SG SG554/92A patent/SG55492G/en unknown
- 1992-06-10 MX MX9202772A patent/MX9202772A/es unknown
- 1992-11-05 HK HK874/92A patent/HK87492A/xx not_active IP Right Cessation
1994
- 1994-01-24 BG BG098407A patent/BG61519B2/bg unknown
1998
- 1998-10-21 LU LU90301C patent/LU90301I2/fr unknown
- 1998-11-18 NL NL980034C patent/NL980034I1/nl unknown
1999
- 1999-07-20 NO NO1999016C patent/NO1999016I1/no unknown

Also Published As

Publication number	Publication date
NO168302B (no)	1991-10-28
EP0207331A1 (fr)	1987-01-07
DE19875044I2 (de)	2002-07-18
JPS60158171A (ja)	1985-08-19
AU583631B2 (en)	1989-05-04
DE3347565A1 (de)	1985-07-11
JPS62474A (ja)	1987-01-06
ES8604546A1 (es)	1986-02-01
FI80447B (fi)	1990-02-28
DE3478682D1 (en)	1989-07-20
KR900005320B1 (ko)	1990-07-27
AU3721084A (en)	1985-08-01
PT79772A (de)	1985-01-01
IE843349L (en)	1985-06-30
EP0147850B1 (fr)	1989-06-14
SG55492G (en)	1992-10-02
NO845282L (no)	1985-07-01
IL73963A (en)	1989-01-31
FI82689C (fi)	1991-04-10
NZ210657A (en)	1988-10-28
HK87492A (en)	1992-11-13
ES8802145A1 (es)	1988-04-01
CA1292000C (fr)	1991-11-12
ES545880A0 (es)	1986-02-01
LU90301I2 (fr)	1998-12-21
PT79772B (de)	1987-01-05
JPH0739405B2 (ja)	1995-05-01
JPH0623200B2 (ja)	1994-03-30
MX9202772A (es)	1992-06-30
ES8604548A1 (es)	1986-02-01
AU577815B2 (en)	1988-10-06
PT82832B (pt)	1988-12-15
EP0147850A3 (en)	1985-08-07
ES8604544A1 (es)	1986-02-01
ES8604547A1 (es)	1986-02-01
NO862532D0 (no)	1986-06-24
ES8604545A1 (es)	1986-02-01
NO168302C (no)	1992-02-05
HUT37773A (en)	1986-02-28
ES539078A0 (es)	1986-03-16
IL79217A (en)	1991-01-31
ZA8410103B (en)	1986-09-24
FI862650L (fi)	1986-12-26
DD231348A5 (de)	1985-12-24
ES545881A0 (es)	1986-02-01
ATE44027T1 (de)	1989-06-15
CA1225398A (fr)	1987-08-11
HU194548B (en)	1988-02-29
NO1999016I1 (no)	1999-07-20
BG61519B2 (bg)	1997-10-31
PT82832A (de)	1986-07-01
EP0207331B1 (fr)	1990-05-23
ES545882A0 (es)	1986-02-01
NZ216640A (en)	1989-02-24
FI80447C (fi)	1990-06-11
DE3522604A1 (de)	1987-01-08
EP0147850A2 (fr)	1985-07-10
ES556495A0 (es)	1988-04-01
FI845145A0 (fi)	1984-12-28
AU5913986A (en)	1987-01-08
DK167573B1 (da)	1993-11-22
ES545879A0 (es)	1986-02-01
GR861558B (en)	1986-10-17
GR82614B (en)	1985-05-02
FI862650A0 (fi)	1986-06-23
ES8605500A1 (es)	1986-03-16
CS409791A3 (en)	1992-07-15
IL73963A0 (en)	1985-03-31
IL79217A0 (en)	1986-09-30
DK613184D0 (da)	1984-12-20
DK296686A (da)	1986-12-26
DK613184A (da)	1985-07-01
ES545883A0 (es)	1986-02-01
DK296686D0 (da)	1986-06-24
DK167439B1 (da)	1993-11-01
ZA864695B (en)	1988-02-24
NO162819B (no)	1989-11-13
FI845145L (fi)	1985-07-01
KR850004590A (ko)	1985-07-25
NO862532L (no)	1986-12-29
IE57700B1 (en)	1993-03-10
NL980034I1 (nl)	1999-02-01
FI82689B (fi)	1990-12-31

Publication	Publication Date	Title
NO162819C (no)	1990-02-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyleddiksyrederivater.
NO171499C (no)	1993-03-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6-dihydro-4h-cyklo-penta(b)tiofen-6-karboksylsyre-derivater
DE3265110D1 (en)	1985-09-05	New compound having antiinflammatory, analgesic and mucoregulating activity, process for its production and relative pharmaceutical compositions

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2003-11-17	SPCG	Granted supplementary protection certificate	Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543, NO , 97-2544, NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817 Spc suppl protection certif: 1999016 Filing date: 19990720 Extension date: 20091228
2005-01-31	MK1K	Patent expired

Date

Code

Title

Description

2003-11-17

SPCG

Granted supplementary protection certificate

Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543, NO , 97-2544, NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817

Spc suppl protection certif: 1999016

Filing date: 19990720

Extension date: 20091228

2005-01-31

MK1K

Patent expired