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NI201300041A - Antagonistas de mdm2 de espiro-oxindol - Google Patents

Antagonistas de mdm2 de espiro-oxindol

Info

Publication number
NI201300041A
NI201300041A NI201300041A NI201300041A NI201300041A NI 201300041 A NI201300041 A NI 201300041A NI 201300041 A NI201300041 A NI 201300041A NI 201300041 A NI201300041 A NI 201300041A NI 201300041 A NI201300041 A NI 201300041A
Authority
NI
Nicaragua
Prior art keywords
spiro
oxindol
mdm2 antagonists
mdm2
antagonists
Prior art date
Application number
NI201300041A
Other languages
English (en)
Inventor
Wang Shaomeng
Zhao Yujun
Sun Wei
Kumar Sanjeev
Leopold Lance
Debussche Laurent
Barriere Cedric
Carry Jean-Christophe
Amaning Kwame
Guo Ming
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of NI201300041A publication Critical patent/NI201300041A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan en la presente compuestos, composiciones y métodos en el campo de la química farmacéutica. Los compuestos y composiciones proporcionados en la presente se relacionan con espiro - oxindoles que funcionan como antagonistas de la interacción entre p53 y MDM2 y su uso como agentes terapéuticos para el tratamiento de cáncer y otras enfermedades.
NI201300041A 2010-11-12 2013-05-09 Antagonistas de mdm2 de espiro-oxindol NI201300041A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US201161470992P 2011-04-01 2011-04-01

Publications (1)

Publication Number Publication Date
NI201300041A true NI201300041A (es) 2013-12-17

Family

ID=46048358

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201300041A NI201300041A (es) 2010-11-12 2013-05-09 Antagonistas de mdm2 de espiro-oxindol

Country Status (27)

Country Link
US (2) US8680132B2 (es)
EP (1) EP2638046A4 (es)
JP (1) JP2014500870A (es)
KR (1) KR101929188B1 (es)
CN (1) CN103298818B (es)
AR (1) AR083849A1 (es)
AU (1) AU2011326395B2 (es)
CA (1) CA2817585A1 (es)
CO (1) CO6721010A2 (es)
CR (1) CR20130271A (es)
DO (1) DOP2013000104A (es)
EA (1) EA201390682A1 (es)
EC (1) ECSP13012678A (es)
GT (1) GT201300118A (es)
IL (1) IL226275A0 (es)
MA (1) MA34732B1 (es)
MX (1) MX2013005238A (es)
NI (1) NI201300041A (es)
NZ (1) NZ611866A (es)
PE (1) PE20140408A1 (es)
PH (1) PH12013500955A1 (es)
SG (1) SG190230A1 (es)
TW (1) TWI535723B (es)
UA (1) UA109464C2 (es)
UY (1) UY33725A (es)
WO (1) WO2012065022A2 (es)
ZA (1) ZA201304042B (es)

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