CL2014001829A1 - Compuestos derivados de indolizina; procedimiento de preparación; composiciones farmacéuticas que los contienen y uso en el tratamiento del cancer. - Google Patents

Compuestos derivados de indolizina; procedimiento de preparación; composiciones farmacéuticas que los contienen y uso en el tratamiento del cancer.

Info

Publication number: CL2014001829A1
Authority: CL; Chile
Prior art keywords: indolizine; cancer; treatment; pharmaceutical compositions; compositions containing
Prior art date: 2012-01-24

Application number

CL2014001829A

Other languages

English (en)

Inventor

Diguarher Thierry Le

Patrick Casara

Jerome-Benoit Starck

Jean-Michel Henlin

James Edward Paul Davidson

James Brooke Murray

Christopher John Graham

I-Jen Chen

Olivier Geneste

John Hickman

Stephane Depil

Tiran Arnaud Le

Miklos Nyerges

Nanteuil Guillaume De

Original Assignee

Servier Lab

Vernalis R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-01-24

Filing date

2014-07-10

Publication date

2015-01-02

2014-07-10 Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab

2015-01-02 Publication of CL2014001829A1 publication Critical patent/CL2014001829A1/es

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pathology (AREA)
Radiology & Medical Imaging (AREA)
Transplantation (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CL2014001829A 2012-01-24 2014-07-10 Compuestos derivados de indolizina; procedimiento de preparación; composiciones farmacéuticas que los contienen y uso en el tratamiento del cancer. CL2014001829A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR1200193A FR2986002B1 (fr)	2012-01-24	2012-01-24	Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
CL2014001829A1 true CL2014001829A1 (es)	2015-01-02

Family

ID=47714428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014001829A CL2014001829A1 (es)	2012-01-24	2014-07-10	Compuestos derivados de indolizina; procedimiento de preparación; composiciones farmacéuticas que los contienen y uso en el tratamiento del cancer.

Country Status (50)

Country	Link
US (3)	US9120791B2 (es)
EP (1)	EP2807159B1 (es)
JP (1)	JP5978317B2 (es)
KR (1)	KR101946911B1 (es)
CN (1)	CN104144930B (es)
AP (1)	AP4028A (es)
AR (1)	AR089774A1 (es)
AU (1)	AU2013213474B2 (es)
BR (1)	BR112014018165B1 (es)
CA (1)	CA2861160C (es)
CL (1)	CL2014001829A1 (es)
CR (1)	CR20140311A (es)
CU (1)	CU20140089A7 (es)
CY (1)	CY1118547T1 (es)
DK (1)	DK2807159T3 (es)
DO (1)	DOP2014000156A (es)
EA (1)	EA026641B1 (es)
EC (1)	ECSP14008606A (es)
ES (1)	ES2616679T3 (es)
FR (1)	FR2986002B1 (es)
GE (1)	GEP201606540B (es)
GT (1)	GT201400142A (es)
HK (1)	HK1203507A1 (es)
HR (1)	HRP20170153T1 (es)
HU (1)	HUE031895T2 (es)
IL (1)	IL233663B (es)
JO (1)	JO3195B1 (es)
LT (1)	LT2807159T (es)
MA (1)	MA35903B1 (es)
MD (1)	MD4490C1 (es)
ME (1)	ME02601B (es)
MX (1)	MX351206B (es)
MY (1)	MY172811A (es)
NI (1)	NI201400081A (es)
NZ (1)	NZ626942A (es)
PE (1)	PE20141405A1 (es)
PH (1)	PH12014501488B1 (es)
PL (1)	PL2807159T3 (es)
PT (1)	PT2807159T (es)
RS (1)	RS55739B1 (es)
RU (1)	RU2646223C2 (es)
SA (1)	SA113340219B1 (es)
SG (1)	SG11201403748RA (es)
SI (1)	SI2807159T1 (es)
TN (1)	TN2014000283A1 (es)
TW (1)	TWI476198B (es)
UA (1)	UA112215C2 (es)
UY (1)	UY34578A (es)
WO (1)	WO2013110890A1 (es)
ZA (1)	ZA201405101B (es)

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FR2986002B1 (fr)	2012-01-24	2014-02-21	Servier Lab	Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) *	2013-07-23	2015-01-30	Servier Lab	"nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008979B1 (fr) *	2013-07-23	2015-07-24	Servier Lab	Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008978A1 (fr) *	2013-07-23	2015-01-30	Servier Lab	"nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008975A1 (fr)	2013-07-23	2015-01-30	Servier Lab	Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008977A1 (fr)	2013-07-23	2015-01-30	Servier Lab	Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3015483B1 (fr) *	2013-12-23	2016-01-01	Servier Lab	Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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FR3037956B1 (fr)	2015-06-23	2017-08-04	Servier Lab	Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) *	2015-06-23	2017-08-04	Servier Lab	Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) *	2015-06-23	2019-01-25	Les Laboratoires Servier	Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2017013271A1 (en) *	2015-07-23	2017-01-26	Les Laboratoires Servier	Combination of an inhibitor of phosphatidylinositol 3-kinase delta and a bcl-2 inhibitor, uses and pharmaceutical compositions thereof
UY37316A (es)	2016-07-07	2018-01-31	Servier Lab	Dispersión sólida farmacéutica de un inhibidor de bcl-2, composiciones farmacéuticas de ésta, y usos para el tratamiento de cáncer
UY37342A (es)	2016-07-22	2018-01-31	Servier Lab	Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1, usos y composiciones farmacéuticas de éstos
WO2018158225A1 (en)	2017-02-28	2018-09-07	Les Laboratoires Servier	Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
AR112440A1 (es) *	2017-07-06	2019-10-30	Servier Lab	Forma cristalina de un inhibidor de bcl-2, un proceso para su preparación y composiciones farmacéuticas que la contienen
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FR3072679B1 (fr) *	2017-10-25	2020-10-30	Servier Lab	Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2019134970A1 (en)	2018-01-05	2019-07-11	Les Laboratoires Servier	Novel salts of a bcl-2 inhibitor,related crystalline forms,method for preparing the same and pharmaceutical compositions containing the same
US11318134B2 (en)	2018-01-10	2022-05-03	Recurium Ip Holdings, Llc	Benzamide compounds
EP3752189A2 (en) *	2018-02-16	2020-12-23	Abbvie Inc.	Selective bcl-2 inhibitors in combination with an anti-pd-1 or an anti-pd-l1 antibody for the treatment of cancers
JP2022532335A (ja)	2019-05-14	2022-07-14	レラボラトワールセルヴィエ	ＧＬＹ１０１ＶＡＬ突然変異を有するＢＣＬ－２媒介性ガンの処置に使用するためのＢｃｌ－２阻害剤
AU2020279979A1 (en)	2019-05-20	2021-11-25	Les Laboratoires Servier	Mcl-1 inhibitor antibody-drug conjugates and methods of use
CN117136076A (zh)	2020-11-24	2023-11-28	诺华股份有限公司	Mcl-1抑制剂抗体药物缀合物和使用方法
CA3206906A1 (en)	2021-02-02	2022-08-11	Andras Herner	Selective bcl-xl protac compounds and methods of use
EP4304588A4 (en)	2021-03-12	2025-01-29	Eil Therapeutics, Inc.	COMPOUNDS CONTAINING TETRAHYDROINDOLIZIN-1-CARBOXAMIDE AS BCL-2 INHIBITORS
AU2022429802A1 (en) *	2021-12-29	2024-06-20	Eil Therapeutics, Inc.	Bcl-2 inhibitors
KR20250027281A (ko)	2022-05-20	2025-02-25	노파르티스 아게	Epha2 bcl-xl 억제제 항체-약물 접합체 및 그의 사용 방법
AU2023273734A1 (en)	2022-05-20	2024-12-12	Les Laboratoires Servier	Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
IL317101A (en)	2022-05-20	2025-01-01	Novartis Ag	Antibody-drug conjugates of anticancer compounds and methods of using them
CN120752058A (zh)	2023-03-10	2025-10-03	诺华股份有限公司	panRAS抑制剂抗体-药物缀合物及其使用方法
WO2025111450A1 (en)	2023-11-22	2025-05-30	Les Laboratoires Servier	Anti-cd74 antibody-drug conjugates and methods of use thereof
WO2025111431A1 (en)	2023-11-22	2025-05-30	Les Laboratoires Servier	Anti-cd7 antibody-drug conjugates and methods of use thereof
WO2025215536A1 (en)	2024-04-10	2025-10-16	Novartis Ag	Macrocyclic panras inhibitors for the treatment of cancer

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2012
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2013
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Also Published As

Publication number	Publication date
BR112014018165B1 (pt)	2020-11-17
PT2807159T (pt)	2017-01-05
JP2015506368A (ja)	2015-03-02
EP2807159A1 (fr)	2014-12-03
EA201400833A1 (ru)	2014-12-30
US20170151251A1 (en)	2017-06-01
RU2646223C2 (ru)	2018-03-02
KR20140129052A (ko)	2014-11-06
IL233663B (en)	2018-04-30
ECSP14008606A (es)	2015-07-31
EA026641B1 (ru)	2017-04-28
PH12014501488A1 (en)	2014-09-22
CA2861160A1 (en)	2013-08-01
US9603854B2 (en)	2017-03-28
MD20140084A2 (en)	2014-12-31
KR101946911B1 (ko)	2019-02-12
US20150313911A1 (en)	2015-11-05
HK1203507A1 (en)	2015-10-30
MX351206B (es)	2017-10-05
AU2013213474B2 (en)	2017-06-08
HRP20170153T1 (hr)	2017-03-24
ME02601B (me)	2017-06-20
CR20140311A (es)	2014-10-07
AP2014007882A0 (en)	2014-08-31
US10258626B2 (en)	2019-04-16
UA112215C2 (uk)	2016-08-10
FR2986002A1 (fr)	2013-07-26
CU20140089A7 (es)	2014-11-27
MD4490B1 (ro)	2017-06-30
AU2013213474A1 (en)	2014-07-24
RU2014134388A (ru)	2016-03-27
BR112014018165A8 (pt)	2017-07-11
SI2807159T1 (sl)	2017-03-31
CN104144930B (zh)	2017-02-22
SA113340219B1 (ar)	2015-10-14
CY1118547T1 (el)	2017-07-12
FR2986002B1 (fr)	2014-02-21
ZA201405101B (en)	2015-12-23
UY34578A (es)	2013-09-02
DOP2014000156A (es)	2014-10-15
LT2807159T (lt)	2017-01-10
US20150051189A1 (en)	2015-02-19
HK1201527A1 (en)	2015-09-04
PE20141405A1 (es)	2014-10-20
RS55739B1 (sr)	2017-07-31
NZ626942A (en)	2016-07-29
JP5978317B2 (ja)	2016-08-24
MA35903B1 (fr)	2014-12-01
DK2807159T3 (en)	2017-02-27
TW201335157A (zh)	2013-09-01
HUE031895T2 (hu)	2017-08-28
TN2014000283A1 (fr)	2015-09-30
GEP201606540B (en)	2016-09-12
JO3195B1 (ar)	2018-03-08
MX2014008913A (es)	2015-01-19
MY172811A (en)	2019-12-12
GT201400142A (es)	2015-11-24
WO2013110890A1 (fr)	2013-08-01
MD4490C1 (ro)	2018-01-31
CA2861160C (en)	2016-08-09
TWI476198B (zh)	2015-03-11
ES2616679T3 (es)	2017-06-14
NI201400081A (es)	2014-10-24
PH12014501488B1 (en)	2014-09-22
AR089774A1 (es)	2014-09-17
CN104144930A (zh)	2014-11-12
IL233663A0 (en)	2014-08-31
AP4028A (en)	2017-02-04
EP2807159B1 (fr)	2016-11-23
PL2807159T3 (pl)	2017-04-28
SG11201403748RA (en)	2014-10-30
US9120791B2 (en)	2015-09-01
BR112014018165A2 (es)	2017-06-20

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