MY142404A - A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopram - Google Patents
A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopramInfo
- Publication number
- MY142404A MY142404A MYPI20034948A MYPI20034948A MY142404A MY 142404 A MY142404 A MY 142404A MY PI20034948 A MYPI20034948 A MY PI20034948A MY PI20034948 A MYPI20034948 A MY PI20034948A MY 142404 A MY142404 A MY 142404A
- Authority
- MY
- Malaysia
- Prior art keywords
- diol
- acid addition
- free base
- addition salt
- citalopram
- Prior art date
Links
- 150000002009 diols Chemical class 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229960001653 citalopram Drugs 0.000 title 4
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 1
- -1 citalopram diol Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 15
- 150000003839 salts Chemical class 0.000 abstract 15
- 239000012458 free base Substances 0.000 abstract 11
- 239000002244 precipitate Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 239000000919 ceramic Substances 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200202004 | 2002-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY142404A true MY142404A (en) | 2010-11-30 |
Family
ID=35423357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20034948A MY142404A (en) | 2002-12-23 | 2003-12-22 | A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopram |
Country Status (17)
| Country | Link |
|---|---|
| KR (1) | KR101076640B1 (uk) |
| CN (1) | CN100334071C (uk) |
| AR (1) | AR042655A1 (uk) |
| BR (1) | BR0317629A (uk) |
| DK (1) | DK1581483T3 (uk) |
| EA (1) | EA009061B1 (uk) |
| ES (1) | ES2385975T3 (uk) |
| ME (1) | MEP5708A (uk) |
| MY (1) | MY142404A (uk) |
| PE (1) | PE20050065A1 (uk) |
| PT (1) | PT1581483E (uk) |
| RS (1) | RS52152B (uk) |
| SI (1) | SI1581483T1 (uk) |
| TW (1) | TWI331605B (uk) |
| UA (1) | UA84859C2 (uk) |
| UY (1) | UY28146A1 (uk) |
| ZA (1) | ZA200504715B (uk) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA95199U (uk) | 2014-07-09 | 2014-12-10 | Дозатор з точним дозуванням для сипучих продуктів | |
| CN110590602B (zh) * | 2019-09-25 | 2022-04-05 | 浙江海森药业股份有限公司 | 外消旋西酞普兰二醇的拆分精制方法 |
| CN114763329A (zh) | 2021-01-14 | 2022-07-19 | 浙江华海药业股份有限公司 | 一种西酞普兰关键中间体的纯化方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| AR034612A1 (es) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
-
2003
- 2003-12-18 UA UAA200506921A patent/UA84859C2/uk unknown
- 2003-12-18 ME MEP-57/08A patent/MEP5708A/xx unknown
- 2003-12-18 SI SI200332174T patent/SI1581483T1/sl unknown
- 2003-12-18 DK DK03767476.9T patent/DK1581483T3/da active
- 2003-12-18 CN CNB200380107283XA patent/CN100334071C/zh not_active Expired - Lifetime
- 2003-12-18 KR KR1020057011898A patent/KR101076640B1/ko not_active Expired - Fee Related
- 2003-12-18 ES ES03767476T patent/ES2385975T3/es not_active Expired - Lifetime
- 2003-12-18 PT PT03767476T patent/PT1581483E/pt unknown
- 2003-12-18 BR BR0317629-0A patent/BR0317629A/pt not_active Application Discontinuation
- 2003-12-18 EA EA200501042A patent/EA009061B1/ru not_active IP Right Cessation
- 2003-12-18 TW TW092135925A patent/TWI331605B/zh not_active IP Right Cessation
- 2003-12-18 RS YU20050488A patent/RS52152B/sr unknown
- 2003-12-22 MY MYPI20034948A patent/MY142404A/en unknown
- 2003-12-22 UY UY28146A patent/UY28146A1/es not_active Application Discontinuation
- 2003-12-22 AR ARP030104781A patent/AR042655A1/es unknown
-
2004
- 2004-01-05 PE PE2004000033A patent/PE20050065A1/es not_active Application Discontinuation
-
2005
- 2005-06-09 ZA ZA200504715A patent/ZA200504715B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS20050488A (sr) | 2007-06-04 |
| PE20050065A1 (es) | 2005-02-18 |
| EA009061B1 (ru) | 2007-10-26 |
| SI1581483T1 (sl) | 2012-09-28 |
| ES2385975T3 (es) | 2012-08-06 |
| UY28146A1 (es) | 2004-07-30 |
| KR20050093801A (ko) | 2005-09-23 |
| TWI331605B (en) | 2010-10-11 |
| TW200512202A (en) | 2005-04-01 |
| ME00034B (me) | 2010-02-10 |
| KR101076640B1 (ko) | 2011-10-27 |
| DK1581483T3 (da) | 2012-07-23 |
| BR0317629A (pt) | 2005-11-29 |
| MEP5708A (xx) | 2010-02-10 |
| UA84859C2 (uk) | 2008-12-10 |
| ZA200504715B (en) | 2006-08-30 |
| EA200501042A1 (ru) | 2005-12-29 |
| CN100334071C (zh) | 2007-08-29 |
| CN1729164A (zh) | 2006-02-01 |
| PT1581483E (pt) | 2012-07-24 |
| AR042655A1 (es) | 2005-06-29 |
| RS52152B (sr) | 2012-08-31 |
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