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MXPA04008796A - Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona. - Google Patents

Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona.

Info

Publication number
MXPA04008796A
MXPA04008796A MXPA04008796A MXPA04008796A MXPA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
carbonylamino
derivatives
novel inhibitors
novel
Prior art date
Application number
MXPA04008796A
Other languages
English (en)
Inventor
Marc Gustaaf Celine Verdonck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04008796A publication Critical patent/MXPA04008796A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Esta invencion comprende los compuestos novedosos de la formula (I)(Ver formula I)en la cual n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, y (Ver formula) tienen significados definidos, que poseen actividad enzimatica de inhibicion de desacetilasa de histona; su preparacion, composiciones que los contienen y su uso como una medicina.
MXPA04008796A 2002-03-13 2003-03-11 Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona. MXPA04008796A (es)

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PCT/EP2003/002512 WO2003076395A1 (en) 2002-03-13 2003-03-11 Carbonylamino-derivatives as novel inhibitors of histone deacetylase

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US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
KR20100107509A (ko) 2001-09-14 2010-10-05 9222-9129 퀘벡 인코포레이티드 히스톤 데아세틸라아제의 억제제
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
US7446109B2 (en) 2002-03-13 2008-11-04 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MXPA04008795A (es) * 2002-03-13 2004-11-26 Janssen Pharmaceutica Nv Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona.
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US20090042920A1 (en) 2009-02-12
US20050148613A1 (en) 2005-07-07
EP1485348B1 (en) 2008-06-11
DE60321548D1 (de) 2008-07-24
HRP20040805A2 (en) 2005-04-30
CN1642907A (zh) 2005-07-20
CA2476067A1 (en) 2003-09-18
OA12789A (en) 2006-07-10
CA2476067C (en) 2011-09-20
US20120041001A1 (en) 2012-02-16
US7446109B2 (en) 2008-11-04
DK1485348T3 (da) 2008-09-29

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