MXPA04001664A - Proceso para la preparacion de acido 6-(4-clorofenil)-2, 2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-acetico. - Google Patents
Proceso para la preparacion de acido 6-(4-clorofenil)-2, 2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-acetico.Info
- Publication number
- MXPA04001664A MXPA04001664A MXPA04001664A MXPA04001664A MXPA04001664A MX PA04001664 A MXPA04001664 A MX PA04001664A MX PA04001664 A MXPA04001664 A MX PA04001664A MX PA04001664 A MXPA04001664 A MX PA04001664A MX PA04001664 A MXPA04001664 A MX PA04001664A
- Authority
- MX
- Mexico
- Prior art keywords
- dimethyl
- dihydro
- chlorophenyl
- phenyl
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invencion se refiere a un proceso para la preparacion de acido 6-(4-clorofenil)-2,2-dimetil-7-fenil- 2,3- dihidro-1H-pirrolizin-5-il-acetico, en el cual se transforma 5- bencil-3,3-dimetil-3,4-dihidro-2H-pirrol con ?-bromo-4- cloroacetofenona bajo formacion de 6-(4-clorofenil)-2,2- dimetil-7-fenil-2,3-dihidro-1H-pirrolizina y se introduce el grupo acido acetico en la posicion 5, obteniendose de alli 5- bencil-3,3-dimetil-3,4-dihidro-2H-pirrol por hidrogenacion de 2,2-dimetil-4-oxo-5-fenil-valeronitrilo o un cetal. La invencion se refiere tambien a un proceso para la preparacion de los productos intermedios que aparecen en el proceso antes mencionado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10141285A DE10141285A1 (de) | 2001-08-23 | 2001-08-23 | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| PCT/EP2002/009356 WO2003018583A1 (de) | 2001-08-23 | 2002-08-21 | Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04001664A true MXPA04001664A (es) | 2004-05-31 |
Family
ID=7696330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04001664A MXPA04001664A (es) | 2001-08-23 | 2002-08-21 | Proceso para la preparacion de acido 6-(4-clorofenil)-2, 2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-acetico. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7078535B2 (es) |
| EP (1) | EP1419160B1 (es) |
| JP (1) | JP4195379B2 (es) |
| KR (1) | KR100687472B1 (es) |
| CN (1) | CN1266152C (es) |
| AR (1) | AR035117A1 (es) |
| AT (1) | ATE417047T1 (es) |
| AU (1) | AU2002331168C1 (es) |
| BR (1) | BR0212009A (es) |
| CA (1) | CA2458339C (es) |
| CO (1) | CO5560556A2 (es) |
| CU (1) | CU23345A3 (es) |
| CY (1) | CY1109089T1 (es) |
| DE (2) | DE10141285A1 (es) |
| DK (1) | DK1419160T3 (es) |
| EA (1) | EA006436B1 (es) |
| ES (1) | ES2319268T3 (es) |
| GE (1) | GEP20063918B (es) |
| HR (1) | HRP20040263B1 (es) |
| HU (1) | HU228125B1 (es) |
| IL (2) | IL160047A0 (es) |
| MX (1) | MXPA04001664A (es) |
| NO (1) | NO328299B1 (es) |
| NZ (1) | NZ531113A (es) |
| PL (1) | PL367796A1 (es) |
| PT (1) | PT1419160E (es) |
| RS (1) | RS51877B (es) |
| TW (1) | TWI274755B (es) |
| UA (1) | UA75702C2 (es) |
| WO (1) | WO2003018583A1 (es) |
| ZA (1) | ZA200402209B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
| CZ2007752A3 (cs) * | 2007-10-30 | 2009-05-13 | Zentiva, A. S. | Nový zpusob výroby 2-(6-(4-chlorfenyl)-2,2-dimethyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl)octové kyseliny (licofelonu) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172371A1 (de) | 1984-07-27 | 1986-02-26 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Dehydroxypantolacton |
| DE3915450A1 (de) | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
| DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
| DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| CN1160357C (zh) * | 2000-01-28 | 2004-08-04 | 默克勒有限公司 | 制备6-(4-氯苯基)-2,2-二甲基-7-苯基-2,3-二氢-1h-吡咯嗪-5-基乙酸的方法 |
-
2001
- 2001-08-23 DE DE10141285A patent/DE10141285A1/de not_active Withdrawn
-
2002
- 2002-08-13 AR ARP020103045A patent/AR035117A1/es active IP Right Grant
- 2002-08-21 MX MXPA04001664A patent/MXPA04001664A/es active IP Right Grant
- 2002-08-21 NZ NZ531113A patent/NZ531113A/en not_active IP Right Cessation
- 2002-08-21 US US10/486,911 patent/US7078535B2/en not_active Expired - Fee Related
- 2002-08-21 EA EA200400344A patent/EA006436B1/ru not_active IP Right Cessation
- 2002-08-21 AU AU2002331168A patent/AU2002331168C1/en not_active Ceased
- 2002-08-21 KR KR1020047002654A patent/KR100687472B1/ko not_active Expired - Fee Related
- 2002-08-21 CN CNB028164490A patent/CN1266152C/zh not_active Expired - Fee Related
- 2002-08-21 DE DE50213105T patent/DE50213105D1/de not_active Expired - Lifetime
- 2002-08-21 HR HRP20040263AA patent/HRP20040263B1/xx not_active IP Right Cessation
- 2002-08-21 BR BR0212009-7A patent/BR0212009A/pt not_active Application Discontinuation
- 2002-08-21 HU HU0401440A patent/HU228125B1/hu not_active IP Right Cessation
- 2002-08-21 JP JP2003523244A patent/JP4195379B2/ja not_active Expired - Fee Related
- 2002-08-21 UA UA2004032036A patent/UA75702C2/uk unknown
- 2002-08-21 IL IL16004702A patent/IL160047A0/xx unknown
- 2002-08-21 GE GE5474A patent/GEP20063918B/en unknown
- 2002-08-21 ES ES02767415T patent/ES2319268T3/es not_active Expired - Lifetime
- 2002-08-21 RS YU14604A patent/RS51877B/sr unknown
- 2002-08-21 PL PL02367796A patent/PL367796A1/xx unknown
- 2002-08-21 EP EP02767415A patent/EP1419160B1/de not_active Expired - Lifetime
- 2002-08-21 DK DK02767415T patent/DK1419160T3/da active
- 2002-08-21 CA CA002458339A patent/CA2458339C/en not_active Expired - Fee Related
- 2002-08-21 PT PT02767415T patent/PT1419160E/pt unknown
- 2002-08-21 WO PCT/EP2002/009356 patent/WO2003018583A1/de not_active Ceased
- 2002-08-21 AT AT02767415T patent/ATE417047T1/de active
- 2002-08-23 TW TW091119151A patent/TWI274755B/zh not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160047A patent/IL160047A/en not_active IP Right Cessation
- 2004-01-29 CU CU20040019A patent/CU23345A3/es not_active IP Right Cessation
- 2004-02-19 CO CO04014456A patent/CO5560556A2/es not_active Application Discontinuation
- 2004-03-19 ZA ZA200402209A patent/ZA200402209B/en unknown
- 2004-03-19 NO NO20041178A patent/NO328299B1/no not_active IP Right Cessation
-
2009
- 2009-03-06 CY CY20091100258T patent/CY1109089T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |