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MX9704145A - Derivados de carboestirilo. - Google Patents

Derivados de carboestirilo.

Info

Publication number
MX9704145A
MX9704145A MX9704145A MX9704145A MX9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A MX 9704145 A MX9704145 A MX 9704145A
Authority
MX
Mexico
Prior art keywords
lower alkyl
optionally substituted
cycloalkyl
lower alkoxy
alkoxy
Prior art date
Application number
MX9704145A
Other languages
English (en)
Inventor
Yasuo Koga
Yoshito Kihara
Minoru Okada
Takao Nishi
Yoshihiro Inoue
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX9704145A publication Critical patent/MX9704145A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de carboestirilo de la formula (1) en donde A es alquileno inferior, R es H, halogeno o alcoxi inferior; R1 y R2 son cada uno alquilo inferior, que está sustituido opcionalmente por OH, alcoxi inferior, fenil-alcoxi inferior o alcanoiloxi inferior; estando sustituido opcionalmente el cicloalquilo con OH, hidroxi-alcoxi inferior o alcanoiloxi inferior; o estando sustituido opcionalmente el amino con alquilo inferior o cicloalquilo; R3 es H, alquilo inferior, alquenilo inferior o hidroxi-alquilo inferior; y las ligaduras entre las posiciones 3 y 4 del nucleo de carboestirilo es sencilla o doble; a condicion de que cuando R y R3 son H, R1 y R2 no deben ser alquilo inferior no sustituido ni cicloalquilo no sustituido; o una sal del mismo, que muestra actividades antitromboticas, actividad inhibidora del engrosamiento de la region íntima, actividad disociadora de la masa de plaquetas y actividad incrementadora del flujo sanguíneo en el cerebro y en los vasos periféricos y por lo tanto, es util como medicina en la profilaxia o en el tratamiento de diversas enfermedades isquémicas.
MX9704145A 1995-10-05 1996-10-04 Derivados de carboestirilo. MX9704145A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25870595 1995-10-05
PCT/JP1996/002892 WO1997012869A1 (en) 1995-10-05 1996-10-04 Carbostyril derivatives as antithrombotic agents

Publications (1)

Publication Number Publication Date
MX9704145A true MX9704145A (es) 1997-09-30

Family

ID=17323960

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704145A MX9704145A (es) 1995-10-05 1996-10-04 Derivados de carboestirilo.

Country Status (13)

Country Link
US (1) US6143763A (es)
EP (1) EP0796248B1 (es)
KR (1) KR100230639B1 (es)
CN (1) CN1131213C (es)
AR (1) AR004686A1 (es)
AT (1) ATE204255T1 (es)
AU (1) AU690861B2 (es)
CA (1) CA2207185C (es)
DE (1) DE69614503T2 (es)
ES (1) ES2162655T3 (es)
MX (1) MX9704145A (es)
TW (1) TW338037B (es)
WO (1) WO1997012869A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002509928A (ja) * 1998-03-31 2002-04-02 ワーナー−ランバート・カンパニー セリンプロテアーゼ阻害剤としてのキノロン
CN100506230C (zh) * 2004-02-09 2009-07-01 日产化学工业株式会社 血管内膜增厚抑制剂
JP4892477B2 (ja) * 2005-06-08 2012-03-07 興和株式会社 新規なトリグリセリド低下剤
CA2771136A1 (en) 2009-08-21 2011-02-24 Otsuka Pharmaceutical Co., Ltd. Process for producing benzo[b][1,4]diazepine-2,4-dione compound
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US20140330022A1 (en) 2012-01-05 2014-11-06 Kowa Company, Ltd. Collateral blood circulation development promoter
WO2019054432A1 (ja) 2017-09-13 2019-03-21 国立大学法人浜松医科大学 大動脈瘤の治療用医薬組成物
SG11202109928WA (en) 2019-03-13 2021-10-28 National Univ Corporation Hamamatsu Univ School Of Medicine Pharmaceutical composition for treating aortic aneurysm
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004042A1 (en) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor

Also Published As

Publication number Publication date
HK1002194A1 (en) 1998-08-07
WO1997012869A1 (en) 1997-04-10
AU7145796A (en) 1997-04-28
DE69614503T2 (de) 2002-04-11
CA2207185C (en) 2008-08-19
CN1172478A (zh) 1998-02-04
ES2162655T3 (es) 2002-01-01
TW338037B (en) 1998-08-11
AU690861B2 (en) 1998-04-30
ATE204255T1 (de) 2001-09-15
EP0796248A1 (en) 1997-09-24
AR004686A1 (es) 1999-03-10
KR100230639B1 (ko) 1999-11-15
DE69614503D1 (en) 2001-09-20
EP0796248B1 (en) 2001-08-16
CN1131213C (zh) 2003-12-17
CA2207185A1 (en) 1997-04-10
US6143763A (en) 2000-11-07

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