AR004686A1 - Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivado - Google Patents
Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivadoInfo
- Publication number
- AR004686A1 AR004686A1 ARP960104540A ARP960104540A AR004686A1 AR 004686 A1 AR004686 A1 AR 004686A1 AR P960104540 A ARP960104540 A AR P960104540A AR P960104540 A ARP960104540 A AR P960104540A AR 004686 A1 AR004686 A1 AR 004686A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivative
- activity
- optionally substituted
- alkyl
- cycloalkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000023589 ischemic disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000008719 thickening Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de carboestirilo de la formula (I): en donde A es un alquileno inferior, R es H, halogeno o alcoxilo inferior; R1 y R2 son cada uno alquiloinferior que son opcionalmente sustituidos por OH, alcoxilo inferior, alcoxilo inferior fenilo oalcanoiloxilo inferior, cicloalquilo que es sustituidoopcionalmente por OH, alcoxilo inferior - hidroxilo o alcanoiloxilo inferior, o amino que es opcionalmente sustituido por alquilo inferior o cicloalquilo; R3es H, alquilo inferior, alqueniloinfer ior o alquilo inferior hidroxilo, y el enlace entre posiciones 3- y 4- del nucleo de carboesterilo es simple o doble,a condicion de que cuando R y R3 sean H, R1 y R2 no deberian ser alquilo inferior insustituido o cicloalquiloinsustituido, o una sal de los mismos, loscuales presentan actividad antitrombotica, actividad inhibitoria de espesamiento de la intima actividad disociativa de la masa de plaquetas yactividad que incrementa el flujo sanguineo en elcerebro y en los va sos perifericos, y por tanto, son utiles como medicina en profilaxis otratamiento de diversas enfermedades isquemicas. Se describe un proceso para preparar el derivado de carboestirilo arriba mencionado y unacomposicion quecontiene el comp uesto activo en cantidad terapeuticamente efectiva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25870595 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004686A1 true AR004686A1 (es) | 1999-03-10 |
Family
ID=17323960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104540A AR004686A1 (es) | 1995-10-05 | 1996-09-30 | Derivado de carboestirilo, composicion farmaceutica que lo contiene y procedimiento para la preparacion de dicho derivado |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6143763A (es) |
| EP (1) | EP0796248B1 (es) |
| KR (1) | KR100230639B1 (es) |
| CN (1) | CN1131213C (es) |
| AR (1) | AR004686A1 (es) |
| AT (1) | ATE204255T1 (es) |
| AU (1) | AU690861B2 (es) |
| CA (1) | CA2207185C (es) |
| DE (1) | DE69614503T2 (es) |
| ES (1) | ES2162655T3 (es) |
| MX (1) | MX9704145A (es) |
| TW (1) | TW338037B (es) |
| WO (1) | WO1997012869A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855726B1 (en) | 1998-03-31 | 2005-02-15 | Warner-Lambert Company Llc | Quinolones as serine protease inhibitors |
| CN100506230C (zh) * | 2004-02-09 | 2009-07-01 | 日产化学工业株式会社 | 血管内膜增厚抑制剂 |
| WO2006132091A1 (ja) * | 2005-06-08 | 2006-12-14 | Kowa Company, Ltd. | 新規なトリグリセリド低下剤 |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| BR112012003871A2 (pt) | 2009-08-21 | 2015-09-08 | Otsuka Pharma Co Ltd | processo para a produção de composto de benzo[b][1,4]diazepina-2,4-diona |
| US20140330022A1 (en) | 2012-01-05 | 2014-11-06 | Kowa Company, Ltd. | Collateral blood circulation development promoter |
| JP7300387B2 (ja) | 2017-09-13 | 2023-06-29 | 国立大学法人浜松医科大学 | 大動脈瘤の治療用医薬組成物 |
| KR20210144657A (ko) | 2019-03-13 | 2021-11-30 | 고쿠리츠다이가쿠호진 하마마츠이카다이가쿠 | 대동맥류의 치료용 의약 조성물 |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930702307A (ko) * | 1991-08-23 | 1993-09-08 | 오오쓰까 아끼히꼬 | 카르보스티릴 유도체 및 혈소판 응집 억제제 |
-
1996
- 1996-09-25 TW TW085111708A patent/TW338037B/zh not_active IP Right Cessation
- 1996-09-30 AR ARP960104540A patent/AR004686A1/es active IP Right Grant
- 1996-10-04 CA CA002207185A patent/CA2207185C/en not_active Expired - Fee Related
- 1996-10-04 EP EP96932816A patent/EP0796248B1/en not_active Expired - Lifetime
- 1996-10-04 MX MX9704145A patent/MX9704145A/es unknown
- 1996-10-04 ES ES96932816T patent/ES2162655T3/es not_active Expired - Lifetime
- 1996-10-04 KR KR1019970703738A patent/KR100230639B1/ko not_active Expired - Lifetime
- 1996-10-04 WO PCT/JP1996/002892 patent/WO1997012869A1/en not_active Ceased
- 1996-10-04 US US08/849,664 patent/US6143763A/en not_active Expired - Lifetime
- 1996-10-04 AU AU71457/96A patent/AU690861B2/en not_active Ceased
- 1996-10-04 DE DE69614503T patent/DE69614503T2/de not_active Expired - Lifetime
- 1996-10-04 CN CN96191700A patent/CN1131213C/zh not_active Expired - Fee Related
- 1996-10-04 AT AT96932816T patent/ATE204255T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69614503D1 (en) | 2001-09-20 |
| ATE204255T1 (de) | 2001-09-15 |
| MX9704145A (es) | 1997-09-30 |
| CN1172478A (zh) | 1998-02-04 |
| EP0796248A1 (en) | 1997-09-24 |
| CN1131213C (zh) | 2003-12-17 |
| EP0796248B1 (en) | 2001-08-16 |
| DE69614503T2 (de) | 2002-04-11 |
| CA2207185A1 (en) | 1997-04-10 |
| CA2207185C (en) | 2008-08-19 |
| AU7145796A (en) | 1997-04-28 |
| AU690861B2 (en) | 1998-04-30 |
| ES2162655T3 (es) | 2002-01-01 |
| US6143763A (en) | 2000-11-07 |
| HK1002194A1 (en) | 1998-08-07 |
| TW338037B (en) | 1998-08-11 |
| KR100230639B1 (ko) | 1999-11-15 |
| WO1997012869A1 (en) | 1997-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |