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MX2022013192A - Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer. - Google Patents

Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

Info

Publication number
MX2022013192A
MX2022013192A MX2022013192A MX2022013192A MX2022013192A MX 2022013192 A MX2022013192 A MX 2022013192A MX 2022013192 A MX2022013192 A MX 2022013192A MX 2022013192 A MX2022013192 A MX 2022013192A MX 2022013192 A MX2022013192 A MX 2022013192A
Authority
MX
Mexico
Prior art keywords
fgfr2
combination
cancer treatment
inhibitors
immune stimulating
Prior art date
Application number
MX2022013192A
Other languages
English (en)
Inventor
Kristen Pierce
Robert Sikorski
Janine Powers
Servando Palencia
Majid Ghoddusi
Kartik Krishnan
Original Assignee
Five Prime Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc filed Critical Five Prime Therapeutics Inc
Publication of MX2022013192A publication Critical patent/MX2022013192A/es

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Abstract

En la presente se proporcionan usos de inhibidores del receptor 2 del factor de crecimiento de fibroblastos (FGFR2) en el tratamiento contra el cáncer, en algunos casos en combinación con agentes que estimulan el sistema inmunitario, tales como inhibidores de PD-1 o PD-L1. En algunas modalidades, los inhibidores de FGFR2 pueden comprender anticuerpos de FGFR2 o polipéptidos de dominio extracelular (ECD) de FGFR2 o moléculas de fusión de ECD de FGFR2 que comprenden un ECD de FGFR2 y un compañero de fusión. En algunas modalidades, los inhibidores de PD-1/PD-L1 pueden comprender anticuerpos anti-PD-1 tales como anticuerpos que se unen a PD-1 o a PD-L1 e inhiben interacciones entre esas proteínas, así como polipéptidos o proteínas de fusión de PD-1.
MX2022013192A 2015-11-23 2018-05-18 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer. MX2022013192A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258731P 2015-11-23 2015-11-23
US201662314174P 2016-03-28 2016-03-28
US201662379094P 2016-08-24 2016-08-24

Publications (1)

Publication Number Publication Date
MX2022013192A true MX2022013192A (es) 2022-11-14

Family

ID=57589165

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018006181A MX2018006181A (es) 2015-11-23 2016-11-22 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.
MX2022013192A MX2022013192A (es) 2015-11-23 2018-05-18 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

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MX2018006181A MX2018006181A (es) 2015-11-23 2016-11-22 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

Country Status (14)

Country Link
US (4) US20170145103A1 (es)
EP (1) EP3380523A1 (es)
JP (3) JP7349787B2 (es)
KR (2) KR20250034528A (es)
CN (2) CN108368174B (es)
AU (2) AU2016359609B2 (es)
BR (1) BR112018010410A8 (es)
CA (1) CA3004794A1 (es)
IL (2) IL291926B2 (es)
MX (2) MX2018006181A (es)
RU (1) RU2745707C2 (es)
SG (2) SG11201804134YA (es)
TW (2) TWI881245B (es)
WO (2) WO2017091580A1 (es)

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NZ715201A (en) 2013-08-01 2021-12-24 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
EP3380523A1 (en) * 2015-11-23 2018-10-03 Five Prime Therapeutics, Inc. Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
MX384034B (es) 2015-12-17 2025-03-14 Eisai R&D Man Co Ltd Agente terapeutico para cancer de mama.
EP4650004A2 (en) 2017-05-16 2025-11-19 Five Prime Therapeutics, Inc. Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
CN111821434A (zh) * 2019-04-17 2020-10-27 上海君实生物医药科技股份有限公司 抗pd-1抗体在制备治疗实体瘤的药物中的用途
CN108440673B (zh) * 2018-04-08 2021-08-17 海南医学院 Fc融合蛋白PD1/FGFR1及其应用
CN112118858A (zh) * 2018-05-15 2020-12-22 默克专利有限公司 用于未经治疗对象中癌症治疗的靶向tgf-β抑制的给药方案
WO2020047322A1 (en) * 2018-08-29 2020-03-05 Shattuck Labs, Inc. Combination therapies comprising tim-3-based chimeric proteins
MX2021002208A (es) * 2018-08-29 2021-05-14 Five Prime Therapeutics Inc Regimenes de dosificacion de la proteina de fusion de fc y dominio extracelular del cd80.
US20220048883A1 (en) * 2018-09-13 2022-02-17 University Of Southern California Novel fgfr inhibitors and uses thereof
AU2019355995A1 (en) 2018-10-05 2021-04-08 Five Prime Therapeutics, Inc. Anti-FGFR2 antibody formulations
JP2022507606A (ja) * 2018-11-16 2022-01-18 ネオイミューンテック， インコーポレイテッド Ｉｌ－７タンパク質と免疫チェックポイント阻害剤の組み合わせで腫瘍を治療する方法
JP2022522479A (ja) * 2019-02-28 2022-04-19 シャタック ラボ，インコーポレイテッド 併用療法
EP3932425A4 (en) * 2019-02-28 2022-12-07 Taiho Pharmaceutical Co., Ltd. CANCER THERAPY WITH 3,5-DISUBSTITUTED BENZENE ALKINYL COMPOUND AND IMMUNE CHECKPOINT INHIBITOR
EP3953713A1 (en) * 2019-04-12 2022-02-16 STRATIFYER Molecular Pathology GmbH Method of classifying a sample based on determination of fgfr
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