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MX2018006181A - Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer. - Google Patents

Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

Info

Publication number
MX2018006181A
MX2018006181A MX2018006181A MX2018006181A MX2018006181A MX 2018006181 A MX2018006181 A MX 2018006181A MX 2018006181 A MX2018006181 A MX 2018006181A MX 2018006181 A MX2018006181 A MX 2018006181A MX 2018006181 A MX2018006181 A MX 2018006181A
Authority
MX
Mexico
Prior art keywords
fgfr2
stimulate
agents
combination
immune system
Prior art date
Application number
MX2018006181A
Other languages
English (en)
Inventor
Pierce Kristen
Sikorski Robert
Powers Janine
Palencia Servando
Ghoddusi Majid
Krishnan Kartik
Original Assignee
Five Prime Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc filed Critical Five Prime Therapeutics Inc
Publication of MX2018006181A publication Critical patent/MX2018006181A/es

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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  • Health & Medical Sciences (AREA)
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Abstract

En la presente se proporcionan usos de inhibidores del receptor 2 del factor de crecimiento de fibroblastos (FGFR2) en el tratamiento contra el cáncer, en algunos casos en combinación con agentes que estimulan el sistema inmunitario, tales como inhibidores de PD-1 o PD-L1. En algunas modalidades, los inhibidores de FGFR2 pueden comprender anticuerpos de FGFR2 o polipéptidos de dominio extracelular (ECD) de FGFR2 o moléculas de fusión de ECD de FGFR2 que comprenden un ECD de FGFR2 y un compañero de fusión. En algunas modalidades, los inhibidores de PD-1/PD-L1 pueden comprender anticuerpos anti-PD-1 tales como anticuerpos que se unen a PD-1 o a PD-L1 e inhiben interacciones entre esas proteínas, así como polipéptidos o proteínas de fusión de PD-1.
MX2018006181A 2015-11-23 2016-11-22 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer. MX2018006181A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562258731P 2015-11-23 2015-11-23
US201662314174P 2016-03-28 2016-03-28
US201662379094P 2016-08-24 2016-08-24
PCT/US2016/063332 WO2017091577A1 (en) 2015-11-23 2016-11-22 Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment

Publications (1)

Publication Number Publication Date
MX2018006181A true MX2018006181A (es) 2018-09-24

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ID=57589165

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MX2018006181A MX2018006181A (es) 2015-11-23 2016-11-22 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.
MX2022013192A MX2022013192A (es) 2015-11-23 2018-05-18 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

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MX2022013192A MX2022013192A (es) 2015-11-23 2018-05-18 Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.

Country Status (14)

Country Link
US (4) US11447553B2 (es)
EP (1) EP3380523A1 (es)
JP (3) JP7349787B2 (es)
KR (2) KR20250034528A (es)
CN (2) CN108368174B (es)
AU (2) AU2016359609B2 (es)
BR (1) BR112018010410A8 (es)
CA (1) CA3004794A1 (es)
IL (2) IL291926B2 (es)
MX (2) MX2018006181A (es)
RU (1) RU2745707C2 (es)
SG (2) SG10201913538VA (es)
TW (2) TWI791422B (es)
WO (2) WO2017091577A1 (es)

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PE20210949A1 (es) 2013-08-01 2021-05-24 Five Prime Therapeutics Inc Anticuerpos anti-fgfr2iiib afucosilados
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
TWI791422B (zh) * 2015-11-23 2023-02-11 美商戊瑞治療有限公司 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合
SG10201913213WA (en) 2015-12-17 2020-03-30 Eisai R&D Man Co Ltd Therapeutic agent for breast cancer
ES3041987T3 (en) 2017-05-16 2025-11-17 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
CN111821434A (zh) * 2019-04-17 2020-10-27 上海君实生物医药科技股份有限公司 抗pd-1抗体在制备治疗实体瘤的药物中的用途
CN108440673B (zh) * 2018-04-08 2021-08-17 海南医学院 Fc融合蛋白PD1/FGFR1及其应用
AU2019271065A1 (en) * 2018-05-15 2020-11-05 Merck Patent Gmbh Dosing regimens for targeted TGF-B inhibition for use in treating cancer in treatment naive subjects
BR112021003758A2 (pt) * 2018-08-29 2021-05-25 Five Prime Therapeutics, Inc. regimes de dose de proteína de fusão fc do domínio extracelular cd80
CA3109349A1 (en) * 2018-08-29 2020-03-05 Shattuck Labs, Inc. Combination therapies comprising tim-3-based chimeric proteins
US20220048883A1 (en) * 2018-09-13 2022-02-17 University Of Southern California Novel fgfr inhibitors and uses thereof
AU2019355995A1 (en) 2018-10-05 2021-04-08 Five Prime Therapeutics, Inc. Anti-FGFR2 antibody formulations
CN113365650A (zh) * 2018-11-16 2021-09-07 新免疫技术有限公司 用il-7蛋白和免疫检查点抑制剂的组合治疗肿瘤的方法
WO2020175704A1 (ja) * 2019-02-28 2020-09-03 大鵬薬品工業株式会社 ３，５－二置換ベンゼンアルキニル化合物と免疫チェックポイント阻害薬とを用いた癌治療法
CN113747947A (zh) * 2019-02-28 2021-12-03 沙塔克实验室有限公司 组合疗法
CN114450591A (zh) * 2019-04-12 2022-05-06 斯卓蒂费尔分子病理学有限责任公司 基于确定fgfr的分类样本的方法
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