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MX2022005362A - Composiciones de trem para codones con-raros y usos relacionados. - Google Patents

Composiciones de trem para codones con-raros y usos relacionados.

Info

Publication number
MX2022005362A
MX2022005362A MX2022005362A MX2022005362A MX2022005362A MX 2022005362 A MX2022005362 A MX 2022005362A MX 2022005362 A MX2022005362 A MX 2022005362A MX 2022005362 A MX2022005362 A MX 2022005362A MX 2022005362 A MX2022005362 A MX 2022005362A
Authority
MX
Mexico
Prior art keywords
con
trem
compositions
rare codons
related uses
Prior art date
Application number
MX2022005362A
Other languages
English (en)
Inventor
David Arthur Berry
Theonie Anastassiadis
Christine Elizabeth Hajdin
Noubar Boghos Afeyan
Original Assignee
Flagship Pioneering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Inc filed Critical Flagship Pioneering Inc
Publication of MX2022005362A publication Critical patent/MX2022005362A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

En general, la invención se refiere a usos de moléculas efectoras basadas en ARNt (TREM) correspondientes a codones con-raros y métodos de preparación de las mismas.
MX2022005362A 2019-11-04 2020-11-04 Composiciones de trem para codones con-raros y usos relacionados. MX2022005362A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962930361P 2019-11-04 2019-11-04
PCT/US2020/058948 WO2021092064A1 (en) 2019-11-04 2020-11-04 Trem compositions for con-rare codons and related uses

Publications (1)

Publication Number Publication Date
MX2022005362A true MX2022005362A (es) 2022-09-23

Family

ID=73654885

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022005362A MX2022005362A (es) 2019-11-04 2020-11-04 Composiciones de trem para codones con-raros y usos relacionados.

Country Status (9)

Country Link
US (1) US20220364092A1 (es)
EP (1) EP4055163A1 (es)
JP (1) JP2023500116A (es)
KR (1) KR20220128611A (es)
CN (1) CN115003810A (es)
AU (1) AU2020379762A1 (es)
CA (1) CA3160097A1 (es)
MX (1) MX2022005362A (es)
WO (1) WO2021092064A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3081692A1 (en) 2017-11-02 2019-05-09 The Wistar Institute Of Anatomy And Biology Methods of rescuing stop codons via genetic reassignment with ace-trna
WO2021243301A2 (en) * 2020-05-29 2021-12-02 Flagship Pioneering Innovations Vi, Llc. Trem compositions and methods relating thereto
AU2021278984A1 (en) * 2020-05-29 2022-11-17 Flagship Pioneering Innovations Vi, Llc Trem compositions and methods relating thereto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
WO2006105038A2 (en) * 2005-03-25 2006-10-05 The Uab Research Foundation Methods of altering gene expression and methods of treatment utilizing same
GB0600948D0 (en) * 2006-01-18 2006-02-22 Univ Dundee Prevention/Treatment Of Ichthyosis Vulgaris, Atopy And Other Disorders
WO2010141851A1 (en) * 2009-06-05 2010-12-09 Salk Institute For Biological Studies Improving unnatural amino acid incorporation in eukaryotic cells
US9676810B2 (en) * 2010-07-08 2017-06-13 The Brigham And Women's Hospital, Inc. Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules
WO2014055682A1 (en) * 2012-10-02 2014-04-10 Vaxiion Therapeutics, Inc. Immunomodulatory minicells and methods of use
EP3071515A2 (en) 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
HUE054471T2 (hu) 2014-04-01 2021-09-28 Rubius Therapeutics Inc Immunmodulációs módszerek és készítmények
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
HRP20220147T1 (hr) 2016-01-11 2022-04-15 Rubius Therapeutics, Inc. Pripravci i postupci povezani s multimodalnim terapijskim staničnim sustavima za indikacije raka
MX2019000205A (es) 2016-07-07 2019-09-23 Rubius Therapeutics Inc Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno.
JP2019536793A (ja) 2016-12-02 2019-12-19 ルビウス セラピューティクス， インコーポレイテッド 固形腫瘍に浸透させるための細胞系に関連する組成物および方法
BR112019016951A2 (pt) 2017-02-17 2020-05-26 Rubius Therapeutics, Inc. Células eritroides funcionalizadas
KR102761577B1 (ko) 2017-05-08 2025-02-03 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 막 융합을 촉진시키기 위한 조성물 및 그의 용도
EA202190736A1 (ru) * 2018-09-26 2021-09-16 Кейс Вестерн Ризерв Юниверсити Способы и композиции для увеличения экспрессии белка и/или лечения расстройства, связанного с гаплонедостаточностью
KR20210151049A (ko) * 2019-01-18 2021-12-13 플래그쉽 파이어니어링, 인크. Trem 조성물 및 이의 용도
CN114269921A (zh) * 2019-05-31 2022-04-01 旗舰创业股份有限公司 TREM组合物用以调节tRNA池的用途

Also Published As

Publication number Publication date
CA3160097A1 (en) 2021-05-14
WO2021092064A1 (en) 2021-05-14
EP4055163A1 (en) 2022-09-14
US20220364092A1 (en) 2022-11-17
JP2023500116A (ja) 2023-01-04
AU2020379762A1 (en) 2022-05-26
KR20220128611A (ko) 2022-09-21
CN115003810A (zh) 2022-09-02

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