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MX2019000205A - Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno. - Google Patents

Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno.

Info

Publication number
MX2019000205A
MX2019000205A MX2019000205A MX2019000205A MX2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A
Authority
MX
Mexico
Prior art keywords
exogenous rna
compositions
methods related
cell systems
therapeutic cell
Prior art date
Application number
MX2019000205A
Other languages
English (en)
Inventor
J Deans Robert
Mata-Fink Jordi
Harandi Omid
Khanwalkar Urjeet
Hariharan Sneha
Kahvejian Avak
Original Assignee
Rubius Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rubius Therapeutics Inc filed Critical Rubius Therapeutics Inc
Publication of MX2019000205A publication Critical patent/MX2019000205A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0644—Platelets; Megakaryocytes
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    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2510/00—Genetically modified cells
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)

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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Virology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención incluye composiciones y métodos relacionados con células eritroides que comprenden ARN exógeno que codifica una proteína. El ARN exógeno puede comprender una región no traducida heteróloga que comprende un elemento regulador. Como alternativa o en combinación, el ARN exógeno puede comprender modificaciones químicas.
MX2019000205A 2016-07-07 2017-07-07 Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno. MX2019000205A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662359416P 2016-07-07 2016-07-07
PCT/US2017/041155 WO2018009838A1 (en) 2016-07-07 2017-07-07 Compositions and methods related to therapeutic cell systems expressing exogenous rna

Publications (1)

Publication Number Publication Date
MX2019000205A true MX2019000205A (es) 2019-09-23

Family

ID=59564224

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000205A MX2019000205A (es) 2016-07-07 2017-07-07 Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno.

Country Status (10)

Country Link
US (1) US20190161730A1 (es)
EP (1) EP3481943A1 (es)
JP (2) JP2019520829A (es)
KR (1) KR20190026819A (es)
CN (1) CN109526226A (es)
AU (1) AU2017293931A1 (es)
BR (1) BR112019000195A2 (es)
CA (1) CA3029906A1 (es)
MX (1) MX2019000205A (es)
WO (1) WO2018009838A1 (es)

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