[go: up one dir, main page]

MX2022012955A - Composiciones de trem y usos de las mismas. - Google Patents

Composiciones de trem y usos de las mismas.

Info

Publication number
MX2022012955A
MX2022012955A MX2022012955A MX2022012955A MX2022012955A MX 2022012955 A MX2022012955 A MX 2022012955A MX 2022012955 A MX2022012955 A MX 2022012955A MX 2022012955 A MX2022012955 A MX 2022012955A MX 2022012955 A MX2022012955 A MX 2022012955A
Authority
MX
Mexico
Prior art keywords
trem
compositions
trna
naturally occurring
relates generally
Prior art date
Application number
MX2022012955A
Other languages
English (en)
Inventor
Neil Kubica
Theonie Anastassiadis
Qingyi Li
David Charles Donnell Butler
Original Assignee
Flagship Pioneering Innovations Vi Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations Vi Llc filed Critical Flagship Pioneering Innovations Vi Llc
Publication of MX2022012955A publication Critical patent/MX2022012955A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3531—Hydrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)

Abstract

La invención se refiere, en general, a moléculas efectoras basadas en ARNt que tienen una modificación de origen no natural y métodos relacionados con las mismas.
MX2022012955A 2020-04-14 2021-04-14 Composiciones de trem y usos de las mismas. MX2022012955A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063009669P 2020-04-14 2020-04-14
PCT/US2021/027357 WO2021211762A2 (en) 2020-04-14 2021-04-14 Trem compositions and uses thereof

Publications (1)

Publication Number Publication Date
MX2022012955A true MX2022012955A (es) 2023-02-23

Family

ID=78084504

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022012955A MX2022012955A (es) 2020-04-14 2021-04-14 Composiciones de trem y usos de las mismas.

Country Status (12)

Country Link
US (2) US12121531B2 (es)
EP (1) EP4136230A4 (es)
JP (1) JP2023521832A (es)
KR (1) KR20230026992A (es)
CN (1) CN115516090A (es)
AU (1) AU2021255583A1 (es)
BR (1) BR112022020780A2 (es)
CA (1) CA3179869A1 (es)
IL (1) IL297243A (es)
MX (1) MX2022012955A (es)
TW (1) TW202204620A (es)
WO (1) WO2021211762A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202204620A (zh) 2020-04-14 2022-02-01 美商旗艦先鋒創新有限責任公司 Trem組合物及其用途
CN120418430A (zh) * 2021-10-13 2025-08-01 旗舰先锋创新Vi有限责任公司 Trem组合物和使用方法
EP4202045A1 (en) * 2021-12-22 2023-06-28 Universität Hamburg Synthetic transfer rna with modified nucleotides
EP4466353A1 (en) * 2022-01-21 2024-11-27 HC Bioscience, Inc. Modified transfer rna with improved activity
WO2023220083A1 (en) * 2022-05-09 2023-11-16 Flagship Pioneering Innovations Vi, Llc Trem compositions and methods of use for treating proliferative disorders
EP4544043A1 (en) * 2022-06-22 2025-04-30 Flagship Pioneering Innovations VI, LLC Compositions of modified trems and uses thereof
EP4442826A1 (en) 2023-04-06 2024-10-09 Universität Hamburg Synthetic dna construct encoding transfer rna
CN121241138A (zh) * 2023-04-12 2025-12-30 旗舰先锋创新Vi有限责任公司 Trem组合物和使用方法
CN121219411A (zh) * 2023-04-12 2025-12-26 旗舰先锋创新Vi有限责任公司 用于在错义突变的校正中使用的trem
EP4458967A1 (en) 2023-05-02 2024-11-06 Universität Hamburg Pharmaceutical composition comprising multiple suppressor transfer rnas
CN118421791B (zh) * 2024-04-18 2025-08-12 宁波大学 血清tRF在制备非小细胞肺癌诊断或检测试剂中的应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2318374C (en) 1998-01-14 2012-09-04 Human Gene Therapy Research Institute Human suppressor trna oligonucleotides and methods of use for same
AU2023400A (en) 1998-11-12 2000-05-29 Children's Medical Center Corporation Compositions and methods for inhibiting angiogenesis using trna and fragments thereof
US20030083483A1 (en) 1999-05-12 2003-05-01 Ecker David J. Molecular interaction sites of vimentin RNA and methods of modulating the same
US6969763B1 (en) 1999-05-12 2005-11-29 Isis Pharmaceuticals, Inc. Molecular interaction sites of interleukin-2 RNA and methods of modulating the same
FR2902439A1 (fr) 2006-06-14 2007-12-21 Univ Rene Descartes Paris V Et Arn de transfert chimerique et son utilisation pour la production d'arn par une cellule
EP2046954A2 (en) 2006-07-31 2009-04-15 Curevac GmbH NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
DE102007001370A1 (de) 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
US9676810B2 (en) * 2010-07-08 2017-06-13 The Brigham And Women's Hospital, Inc. Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules
EP3266873A1 (en) 2010-11-10 2018-01-10 Nigel L. Webb Nuclions and ribocapsids
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
WO2016115168A1 (en) * 2015-01-12 2016-07-21 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
WO2017085718A1 (en) 2015-11-17 2017-05-26 Anima Biotech Inc. FUNCTIONAL TRANSFER tRNA-APTAMER MOLECULES
GB201600512D0 (en) 2016-01-12 2016-02-24 Univ York Recombinant protein production
US10337065B2 (en) * 2016-04-13 2019-07-02 The Rockefeller University tRNA quantification
JP2020508685A (ja) 2017-03-03 2020-03-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
CA3081692A1 (en) * 2017-11-02 2019-05-09 The Wistar Institute Of Anatomy And Biology Methods of rescuing stop codons via genetic reassignment with ace-trna
AU2019233673B2 (en) * 2018-03-15 2025-05-01 Arcturus Therapeutics, Inc. Synthetic transfer RNA with extended anticodon loop
US11702657B2 (en) 2018-04-20 2023-07-18 The Regents Of The University Of California TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma
WO2019226603A1 (en) * 2018-05-22 2019-11-28 The Regents Of The University Of California Trna/pre-mirna compositions and use in treating cancer
CA3114108A1 (en) 2018-09-26 2020-04-02 Case Western Reserve University Methods and compositions for treating a premature stop codon-mediated disorder
KR20210151049A (ko) * 2019-01-18 2021-12-13 플래그쉽 파이어니어링, 인크. Trem 조성물 및 이의 용도
EP3953469A1 (en) 2019-04-11 2022-02-16 Arcturus Therapeutics, Inc. Synthetic transfer rna with extended anticodon loop
US12139708B2 (en) 2019-06-07 2024-11-12 Massachusetts Institute Of Technology Frameshift suppressor tRNA compositions and methods of use
WO2021035391A1 (zh) 2019-08-23 2021-03-04 澳门科技大学 转运rna分子及其片段用于预防或治疗心脏疾病的用途
WO2021087401A1 (en) * 2019-11-01 2021-05-06 Tevard Bio, Inc. Methods and compositions for treating a premature termination codon-mediated disorder
AU2020396868A1 (en) 2019-12-02 2022-07-14 Shape Therapeutics Inc. Targeted transfer RNAS for treatment of diseases
WO2021142343A1 (en) 2020-01-09 2021-07-15 The Regents Of The University Of California Targeting transfer rna for the suppression of nonsense mutations in messenger rna
TW202204620A (zh) 2020-04-14 2022-02-01 美商旗艦先鋒創新有限責任公司 Trem組合物及其用途

Also Published As

Publication number Publication date
IL297243A (en) 2022-12-01
KR20230026992A (ko) 2023-02-27
JP2023521832A (ja) 2023-05-25
WO2021211762A2 (en) 2021-10-21
WO2021211762A3 (en) 2021-11-18
CA3179869A1 (en) 2021-10-21
EP4136230A2 (en) 2023-02-22
US20250000890A1 (en) 2025-01-02
BR112022020780A2 (pt) 2022-11-29
EP4136230A4 (en) 2024-06-19
US12121531B2 (en) 2024-10-22
CN115516090A (zh) 2022-12-23
TW202204620A (zh) 2022-02-01
US20230054178A1 (en) 2023-02-23
AU2021255583A1 (en) 2022-11-10

Similar Documents

Publication Publication Date Title
MX2022012955A (es) Composiciones de trem y usos de las mismas.
WO2021127283A3 (en) Irak degraders and uses thereof
MX2021010827A (es) Materiales funcionales de origen vegetal.
PH12015501392A1 (en) Pesticidal compositions and processes related thereto
ZA202106602B (en) Claudin 6 antibodies and uses thereof
AU2019267042A8 (en) Novel strain having prophylactic or therapeutic effect on cancer
PH12014500930A1 (en) Pesticidal compositions and processes related thereto
PH12013502686A1 (en) Pesticidal compositions and processes related thereto
PH12015501394A1 (en) Pesticidal compositions and processes related thereto
MX2017013196A (es) Bioconjugados y usos de los mismos.
MX2021008592A (es) Composiciones de trem y usos de las mismas.
GB2568181A (en) Wheat
WO2018140934A8 (en) Compositions and methods for hemoglobin production
WO2021146320A8 (en) Antibody molecules to c5ar1 and uses thereof
MX2024004568A (es) Composiciones de trem y metodos de uso.
WO2021086145A3 (ko) 알룰로스를 포함하는 떡 및 이의 제조방법
MX2022011077A (es) Variantes de transglutaminasa.
WO2020146700A8 (en) Lipid nanoparticles
MX2023011964A (es) Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
MX2025004432A (es) Composiciones para el control de artropodos
MX2022005362A (es) Composiciones de trem para codones con-raros y usos relacionados.
WO2022094238A3 (en) Chicken anemia virus (cav)-based vectors
WO2020186090A3 (en) Activatable specific binding member complexes, and methods of making and using same
TW200732410A (en) Sprayable acoustic compositions
WO2018144870A8 (en) Compositions and methods for inhibiting reticulon 4