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MX2022001671A - Sales de un inhibidor de pd-1/pd-l1. - Google Patents

Sales de un inhibidor de pd-1/pd-l1.

Info

Publication number
MX2022001671A
MX2022001671A MX2022001671A MX2022001671A MX2022001671A MX 2022001671 A MX2022001671 A MX 2022001671A MX 2022001671 A MX2022001671 A MX 2022001671A MX 2022001671 A MX2022001671 A MX 2022001671A MX 2022001671 A MX2022001671 A MX 2022001671A
Authority
MX
Mexico
Prior art keywords
inhibitor
methyl
salts
hydroxypyrrolidi
dimethylbiphenyl
Prior art date
Application number
MX2022001671A
Other languages
English (en)
Inventor
Pingli Liu
Yongzhong Wu
Yongchun Pan
Qun Li
Zhongjiang Jia
David J Meloni
Jiacheng Zhou
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2022001671A publication Critical patent/MX2022001671A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere formas de sal del inhibidor PD-1/PD-L1 del ácido (R)-1-((7-ciano-2-(3'-(3-(((R)-3-hidroxipirro lidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2'-dimetilbifenil-3 -il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico, que incluye métodos de preparación del mismo, donde el compuesto es útil en el tratamiento de varias enfermedades que incluyen enfermedades infecciosas y cáncer.
MX2022001671A 2019-08-09 2020-08-07 Sales de un inhibidor de pd-1/pd-l1. MX2022001671A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962884996P 2019-08-09 2019-08-09
PCT/US2020/045311 WO2021030162A1 (en) 2019-08-09 2020-08-07 Salts of a pd-1/pd-l1 inhibitor

Publications (1)

Publication Number Publication Date
MX2022001671A true MX2022001671A (es) 2022-05-13

Family

ID=72179251

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001671A MX2022001671A (es) 2019-08-09 2020-08-07 Sales de un inhibidor de pd-1/pd-l1.

Country Status (8)

Country Link
US (1) US11753406B2 (es)
EP (1) EP4010342A1 (es)
JP (1) JP7665593B2 (es)
AR (1) AR119624A1 (es)
CA (1) CA3150434A1 (es)
MX (1) MX2022001671A (es)
TW (1) TW202115059A (es)
WO (1) WO2021030162A1 (es)

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IL291471B2 (en) 2019-09-30 2025-04-01 Incyte Corp Pyrimido[3,2–D]pyrimidine compounds as immunomodulators
CN114829366A (zh) 2019-11-11 2022-07-29 因赛特公司 Pd-1/pd-l1抑制剂的盐及结晶形式
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
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WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
WO2022133176A1 (en) * 2020-12-18 2022-06-23 Incyte Corporation Oral formulation for a pd-l1 inhibitor
TW202523304A (zh) 2023-12-06 2025-06-16 美商英塞特公司 包含ｄｇｋ抑制劑及ｐｄ—１／ｐｄ—ｌ１抑制劑之組合療法

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