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MX2022000212A - Compuestos de microarn y metodos para modular la actividad de mir-21. - Google Patents

Compuestos de microarn y metodos para modular la actividad de mir-21.

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Publication number
MX2022000212A
MX2022000212A MX2022000212A MX2022000212A MX2022000212A MX 2022000212 A MX2022000212 A MX 2022000212A MX 2022000212 A MX2022000212 A MX 2022000212A MX 2022000212 A MX2022000212 A MX 2022000212A MX 2022000212 A MX2022000212 A MX 2022000212A
Authority
MX
Mexico
Prior art keywords
activity
mir
methods
compositions
modulating mir
Prior art date
Application number
MX2022000212A
Other languages
English (en)
Inventor
Balkrishen Bhat
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2022000212A publication Critical patent/MX2022000212A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification

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  • Health & Medical Sciences (AREA)
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Abstract

En la presente se describen composiciones y métodos para la inhibición de la actividad de miR-21. Las composiciones tienen determinados patrones de modificación de nucleósidos que proporcionan potentes inhibidores de la actividad de miR-21. Las composiciones pueden usarse para inhibir miR-21 y también para tratar enfermedades asociadas con la expresión anormal de miR-21, tal como fibrosis y cáncer.
MX2022000212A 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21. MX2022000212A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478767P 2011-04-25 2011-04-25
US201161565779P 2011-12-01 2011-12-01

Publications (1)

Publication Number Publication Date
MX2022000212A true MX2022000212A (es) 2022-04-01

Family

ID=46025979

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2019003090A MX393138B (es) 2011-04-25 2012-04-25 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2013012452A MX2013012452A (es) 2011-04-25 2012-04-25 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2022006595A MX2022006595A (es) 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2019003089A MX2019003089A (es) 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2022000212A MX2022000212A (es) 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
MX2019003090A MX393138B (es) 2011-04-25 2012-04-25 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2013012452A MX2013012452A (es) 2011-04-25 2012-04-25 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2022006595A MX2022006595A (es) 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21.
MX2019003089A MX2019003089A (es) 2011-04-25 2013-10-23 Compuestos de microarn y metodos para modular la actividad de mir-21.

Country Status (30)

Country Link
US (7) US9181547B2 (es)
EP (3) EP3211082B1 (es)
JP (2) JP6320292B2 (es)
KR (2) KR20190063482A (es)
CN (3) CN113249381A (es)
AU (4) AU2012249851B2 (es)
BR (1) BR112013027187A2 (es)
CA (2) CA2833615C (es)
CL (1) CL2013003105A1 (es)
CO (1) CO6821889A2 (es)
CY (1) CY1120304T1 (es)
DK (2) DK3211082T3 (es)
EA (1) EA025894B1 (es)
ES (2) ES2621863T3 (es)
HR (2) HRP20170557T2 (es)
HU (2) HUE031595T2 (es)
IL (3) IL229032B (es)
LT (2) LT3211082T (es)
MX (5) MX393138B (es)
MY (2) MY175336A (es)
NZ (1) NZ717921A (es)
PH (1) PH12013502199A1 (es)
PL (2) PL3211082T3 (es)
PT (2) PT2702155T (es)
RS (1) RS61775B1 (es)
SG (1) SG194636A1 (es)
SI (2) SI2702155T1 (es)
TW (2) TWI698445B (es)
UA (1) UA115652C2 (es)
WO (1) WO2012148952A1 (es)

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Publication number Publication date
LT3211082T (lt) 2021-05-10
CL2013003105A1 (es) 2014-08-01
SI2702155T1 (sl) 2017-07-31
EA201391492A1 (ru) 2014-04-30
US20140107183A1 (en) 2014-04-17
CN103620035A (zh) 2014-03-05
US9790496B2 (en) 2017-10-17
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CO6821889A2 (es) 2013-12-31
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EP2702155A1 (en) 2014-03-05
TWI607016B (zh) 2017-12-01
MY175336A (en) 2020-06-19
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US20120270928A1 (en) 2012-10-25
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US8912161B2 (en) 2014-12-16
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AU2020201403A1 (en) 2020-03-12
US20160138016A1 (en) 2016-05-19
DK3211082T3 (da) 2021-05-10
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CA3165397A1 (en) 2012-11-01
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SG194636A1 (en) 2013-12-30
UA115652C2 (uk) 2017-12-11
TWI698445B (zh) 2020-07-11
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AU2012249851B2 (en) 2017-06-08
LT2702155T (lt) 2017-05-10
IL266529A (en) 2019-07-31
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JP2018121646A (ja) 2018-08-09
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IL273381A (en) 2020-05-31
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US20180155719A1 (en) 2018-06-07
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