TN2014000401A1 - Microrna compounds and methods for modulating mir-21 activity - Google Patents
Microrna compounds and methods for modulating mir-21 activityInfo
- Publication number
- TN2014000401A1 TN2014000401A1 TNP2014000401A TN2014000401A TN2014000401A1 TN 2014000401 A1 TN2014000401 A1 TN 2014000401A1 TN P2014000401 A TNP2014000401 A TN P2014000401A TN 2014000401 A TN2014000401 A TN 2014000401A TN 2014000401 A1 TN2014000401 A1 TN 2014000401A1
- Authority
- TN
- Tunisia
- Prior art keywords
- activity
- mir
- methods
- compositions
- modulating mir
- Prior art date
Links
- 108091062762 miR-21 stem-loop Proteins 0.000 title abstract 5
- 108091041631 miR-21-1 stem-loop Proteins 0.000 title abstract 5
- 108091044442 miR-21-2 stem-loop Proteins 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 108091070501 miRNA Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779913P | 2013-03-13 | 2013-03-13 | |
| PCT/US2013/037913 WO2013163258A1 (en) | 2012-04-25 | 2013-04-24 | Microrna compounds and methods for modulating mir-21 activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2014000401A1 true TN2014000401A1 (en) | 2015-12-21 |
Family
ID=55447253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2014000401A TN2014000401A1 (en) | 2013-03-13 | 2014-09-24 | Microrna compounds and methods for modulating mir-21 activity |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2014000401A1 (en) |
-
2014
- 2014-09-24 TN TNP2014000401A patent/TN2014000401A1/en unknown
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