[go: up one dir, main page]

MX2021010611A - Aves con genoma editado. - Google Patents

Aves con genoma editado.

Info

Publication number
MX2021010611A
MX2021010611A MX2021010611A MX2021010611A MX2021010611A MX 2021010611 A MX2021010611 A MX 2021010611A MX 2021010611 A MX2021010611 A MX 2021010611A MX 2021010611 A MX2021010611 A MX 2021010611A MX 2021010611 A MX2021010611 A MX 2021010611A
Authority
MX
Mexico
Prior art keywords
birds
present disclosure
disclosure provides
genome edited
male
Prior art date
Application number
MX2021010611A
Other languages
English (en)
Inventor
Yuval Cinnamon
Cohen Enbal Ben-Tal
Original Assignee
The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo filed Critical The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo
Publication of MX2021010611A publication Critical patent/MX2021010611A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente descripción proporciona casetes de polinucleótidos exógenos para generar células de aves quiméricas y aves quiméricas. Los casetes de polinucleótidos se pueden utilizar para producir un fenotipo condicionalmente letal en embriones de aves machos. En una modalidad, la presente descripción proporciona métodos para destruir embriones de pollos machos in-ovo.
MX2021010611A 2019-03-05 2020-03-03 Aves con genoma editado. MX2021010611A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962814162P 2019-03-05 2019-03-05
PCT/IL2020/050242 WO2020178822A1 (en) 2019-03-05 2020-03-03 Genome-edited birds

Publications (1)

Publication Number Publication Date
MX2021010611A true MX2021010611A (es) 2021-11-12

Family

ID=70190050

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010611A MX2021010611A (es) 2019-03-05 2020-03-03 Aves con genoma editado.

Country Status (13)

Country Link
US (1) US20220136003A1 (es)
EP (1) EP3934417A1 (es)
JP (1) JP7667087B2 (es)
KR (1) KR20210137499A (es)
CN (1) CN113692225B (es)
AR (1) AR118239A1 (es)
AU (1) AU2020232441A1 (es)
BR (1) BR112021017265A2 (es)
CA (1) CA3128360A1 (es)
EA (1) EA202192430A1 (es)
IL (1) IL286011B2 (es)
MX (1) MX2021010611A (es)
WO (1) WO2020178822A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114958913A (zh) * 2017-09-19 2022-08-30 以色列农业和农村发展部农业研究组织(范卡尼中心) 经过基因组编辑的鸟
CN110169392B (zh) * 2019-06-24 2021-06-04 四川省畜牧科学研究院 提高鸡专门化母系繁殖性能的选育方法
TW202241259A (zh) * 2020-12-31 2022-11-01 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） 不育禽類胚胎、其產生及用途
WO2024249570A2 (en) * 2023-06-02 2024-12-05 New York University Single-sex chicken with toxin-antitoxin system
US12369569B1 (en) 2024-07-12 2025-07-29 China Agricultural University Method for generating genome-edited chickens

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
NZ502712A (en) 1997-08-04 2003-01-31 Univ Massachusetts Medium and method for long term culturing of avian primordial germ cells (PGC) in a tissue culture comprising growth factors
WO1999055906A2 (en) * 1998-04-27 1999-11-04 University Health Network Gene screening methods and related assays
US20050249735A1 (en) * 2000-08-07 2005-11-10 Centocor, Inc. Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor
US20040181820A1 (en) * 2001-03-05 2004-09-16 Marta Alonso Nucleic acids for transforming fish cells and methods for their use
EP1504092B2 (en) 2002-03-21 2014-06-25 Sangamo BioSciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
DE10248361A1 (de) * 2002-06-30 2004-01-22 Beisswanger, Roland, Dr. Unterdrückung eines Geschlechtes durch die Veränderung von Geschlechtschromosomen
CA2497913C (en) 2002-09-05 2014-06-03 California Institute Of Technology Use of chimeric nucleases to stimulate gene targeting
US7994388B2 (en) 2003-01-16 2011-08-09 North Carolina State University Depletion of endogenous primordial germ cells in avian species
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
US20060174362A1 (en) * 2005-02-01 2006-08-03 Origen Therapeutics, Inc. Long-term culture of avian primordial germ cells (PGCs)
US8088976B2 (en) * 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
EP2484758B1 (en) 2005-10-18 2013-10-02 Precision Biosciences Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
US20090183269A1 (en) * 2006-02-10 2009-07-16 Oxitec Limited Gene expression system using alternative splicing in insects
AU2008286791A1 (en) * 2007-08-14 2009-02-19 Symphogen A/S Transgenic chickens with an inactivated endogenous gene locus
US7732659B2 (en) * 2007-11-20 2010-06-08 Genetic Services, Inc. Injecting Drosophila embryos
EP2067402A1 (en) 2007-12-07 2009-06-10 Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; Transponson-mediated mutagenesis in spermatogonial stem cells
EP2276838A4 (en) * 2008-04-07 2012-02-01 Nupotential Inc RE-PROGRAMMING A CELL BY INDUCING A PLURIPOTENTIC GENE THROUGH RNA INTERFERENCE
EP2393351A4 (en) 2009-02-08 2012-09-26 Univ Melbourne DETERMINATION OF THE SEX AND METHODS FOR SPECIFYING
US8889662B2 (en) 2009-03-02 2014-11-18 University Of Georgia Research Foundation, Inc. Method to alter sex ratios in avian offspring
US20120192298A1 (en) * 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
BR112012012254B1 (pt) * 2009-11-23 2020-11-24 Aquabounty Technologies, Inc Construto de expressao isolado, e, metodos para produzir um peixe femea de finalizaqao de linhagem, para propagar peixes transgenicos com construto de esterilidade materna, e para gerar uma geraqao esteril de peixes
EP3156062A1 (en) 2010-05-17 2017-04-19 Sangamo BioSciences, Inc. Novel dna-binding proteins and uses thereof
GB201112429D0 (en) * 2011-07-19 2011-08-31 Glaxo Group Ltd Antigen-binding proteins with increased FcRn binding
GB2500113A (en) * 2012-03-05 2013-09-11 Oxitec Ltd Arthropod male germline gene expression system
EP3494997B1 (en) 2012-07-25 2019-09-18 The Broad Institute, Inc. Inducible dna binding proteins and genome perturbation tools and applications thereof
US20150260704A1 (en) * 2012-07-30 2015-09-17 In Ovo B.V. Gender, viability and/or developmental stage determination of avian embryos in ovo
WO2014085593A1 (en) 2012-11-27 2014-06-05 Children's Medical Center Corporation Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
JP6644276B2 (ja) 2014-06-27 2020-02-12 国立研究開発法人産業技術総合研究所 家禽始原生殖細胞の遺伝子改変方法、遺伝子改変された家禽始原生殖細胞、遺伝子改変家禽の生産方法及び家禽卵
JP6497605B2 (ja) * 2014-11-14 2019-04-10 国立研究開発法人農業・食品産業技術総合研究機構 雌蚕致死カイコ系統
EP3078675A1 (en) * 2015-04-10 2016-10-12 Ares Trading S.A. Induction dosing regimen for the treatment of tnf alpha mediated disorders
CN105524941A (zh) * 2016-01-19 2016-04-27 扬州大学 一种特异于禽类原始生殖细胞的基因转移系统及方法
WO2018013759A1 (en) * 2016-07-13 2018-01-18 Yorktown Technologies, L.P. Poultry and offspring sex selection
US12157883B2 (en) * 2017-05-05 2024-12-03 California Institute Of Technology DNA sequence modification-based gene drive
WO2018218299A1 (en) 2017-05-31 2018-12-06 Commonwealth Scientific And Industrial Research Organisation Trait selection in avians
CN114958913A (zh) * 2017-09-19 2022-08-30 以色列农业和农村发展部农业研究组织(范卡尼中心) 经过基因组编辑的鸟

Also Published As

Publication number Publication date
CN113692225B (zh) 2023-04-18
US20220136003A1 (en) 2022-05-05
IL286011B2 (en) 2024-06-01
CN113692225A (zh) 2021-11-23
BR112021017265A2 (pt) 2021-12-21
EA202192430A1 (ru) 2022-02-11
IL286011B1 (en) 2024-02-01
AU2020232441A1 (en) 2021-09-23
CA3128360A1 (en) 2020-09-10
WO2020178822A1 (en) 2020-09-10
KR20210137499A (ko) 2021-11-17
EP3934417A1 (en) 2022-01-12
IL286011A (en) 2021-10-31
JP7667087B2 (ja) 2025-04-22
JP2022522848A (ja) 2022-04-20
AR118239A1 (es) 2021-09-22

Similar Documents

Publication Publication Date Title
MX2021010611A (es) Aves con genoma editado.
CY1122940T1 (el) Μη ανθρωπινα ζωα που εχουν ενα εξανθρωπισμενο γονιδιο προγραμματισμενου κυτταρικου θανατου 1
IL281113A (en) Genetically engineered hematopoietic stem cells and uses thereof
CY1120808T1 (el) Μεθοδοι και συνθεσεις για στοχευμενες γενετικες τροποποιησεις και μεθοδοι χρησης
MX2020005477A (es) Inmunoterapias con el uso de células efectoras potenciadas derivadas de ipsc.
CL2021000356A1 (es) Un método para generar progenie estéril y de un sexo.
PH12020550488A1 (en) Method for increasing fetal hemoglobin expression level
MX2017008190A (es) Metodos y composiciones para la modificacion genetica dirigida a traves de direccionamiento multiple de una sola etapa.
BR112018074794A2 (pt) animal não humano geneticamente modificado, métodos que induz a expressão de um anticorpo, de produção de uma célula t, de um animal não humano e não humano geneticamente modificado, e, célula es de animal não humano geneticamente modificado.
MX2018001776A (es) Celulas para inmunoterapia modificadas geneticamente para dirigirse al antigeno cd38 y para la inactivacion del gen cd38.
MX2020004541A (es) Edicion de genes de celulas primarias.
AR102888A1 (es) Animales no humanos que tienen un gen humanizado de agrupamiento de diferenciación 47
MX392707B (es) LINFOCITOS T ACTIVADOS POR BiTE EX VIVO.
IL288049A (en) Cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance
CL2021003300A1 (es) Métodos para producir plantas con desarrollo de frutas alteradas y plantamétodos para producir plantas con desarrollo de frutas alteradas y plantas derivas de las mismas.
GB2563744A (en) Ring-shaped fish farming system
PE20200091A1 (es) Alimentador de bandeja de pollos de engorda
MX2018003354A (es) Seleccion de celulas pluripotentes para producir ratones hembra xy fertiles.
CL2021000154A1 (es) Un método para generar progenie estéril
NZ728159A (en) Nanos2 knock-out that ablates germline cells
MY182819A (en) Egg tray for incubating and hatching eggs
SG11202109268XA (en) Medium chain triglyceride formulations with improved bioavailiblity and methods related thereto
CL2022000150A1 (es) Alimento completo para animales de acuicultura formado a partir de larvas de insectos
MX2020003123A (es) Aves con genoma editado.
AR099006A1 (es) Gen rf3 restaurador tipo s de la esterilidad citoplasmática masculina del maíz (cms)