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MX2021005024A - Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b. - Google Patents

Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.

Info

Publication number
MX2021005024A
MX2021005024A MX2021005024A MX2021005024A MX2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A
Authority
MX
Mexico
Prior art keywords
receptors
antigen
cell maturation
treatment methods
specific chimeric
Prior art date
Application number
MX2021005024A
Other languages
English (en)
Inventor
Eric L Smith
Blythe D Sather
Aye Chen
Erik Hess
Imus Cyr De
Audrey Olshefsky
Stefan Ponko
Semih Tareen
Mariana Cota Stirner
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021005024A publication Critical patent/MX2021005024A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A61K39/001117—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR] or CD30
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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Abstract

En la presente se proporcionan métodos de terapia celular adoptiva que implican la administración de dosis de células para tratar enfermedades y condiciones, incluidas ciertas malignidades de células plasmáticas. Las células expresan en general receptores recombinantes tal como receptores de antígenos quiméricos (CAR) específicos para el antígeno de maduración de células B (BCMA). En algunas modalidades, los métodos son para tratar sujetos con mieloma múltiple (MM). También se proporcionan células modificadas genéticamente que contienen estos receptores de unión a BCMA para usos en la terapia celular adoptiva.
MX2021005024A 2018-11-01 2019-10-31 Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b. MX2021005024A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862754577P 2018-11-01 2018-11-01
US201862774167P 2018-11-30 2018-11-30
US201862774856P 2018-12-03 2018-12-03
US201862777066P 2018-12-07 2018-12-07
US201962845817P 2019-05-09 2019-05-09
PCT/US2019/059271 WO2020092848A2 (en) 2018-11-01 2019-10-31 Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen

Publications (1)

Publication Number Publication Date
MX2021005024A true MX2021005024A (es) 2021-07-21

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Application Number Title Priority Date Filing Date
MX2021005024A MX2021005024A (es) 2018-11-01 2019-10-31 Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.

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Country Link
US (1) US12473345B2 (es)
EP (1) EP3873943A2 (es)
JP (1) JP7510413B2 (es)
KR (1) KR20210113169A (es)
CN (1) CN113646335A (es)
AU (1) AU2019372331A1 (es)
BR (1) BR112021008289A2 (es)
CA (1) CA3117419A1 (es)
IL (1) IL282667A (es)
MA (1) MA54078A (es)
MX (1) MX2021005024A (es)
SG (1) SG11202104188VA (es)
WO (1) WO2020092848A2 (es)

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BR112019017120A8 (pt) 2017-02-17 2023-05-02 Hutchinson Fred Cancer Res Terapias de combinação para tratamento de cânceres e distúrbios autoimunes relacionados a bcma
PT3703750T (pt) 2017-11-01 2025-01-17 Memorial Sloan Kettering Cancer Center Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes
MA50564A (fr) 2017-11-06 2020-09-16 Hutchinson Fred Cancer Res Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase
EP3873943A2 (en) 2018-11-01 2021-09-08 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
IL282886B2 (en) 2018-11-08 2025-07-01 Juno Therapeutics Inc Methods and combinations for T-cell therapy and modulation
CN114364801B (zh) 2019-05-30 2024-04-19 莱蒂恩技术公司 用于用抗bcma免疫治疗来治疗癌症的组合物和方法
EP4142723A2 (en) * 2020-04-28 2023-03-08 Juno Therapeutics, Inc. Combination of bcma-directed t cell therapy and an immunomodulatory compound
JP2023525049A (ja) * 2020-05-08 2023-06-14 シアトル・チルドレンズ・ホスピタル・ドゥーイング／ビジネス／アズ・シアトル・チルドレンズ・リサーチ・インスティテュート ナチュラルキラー細胞を標的とするキメラ抗原受容体（ｃａｒ）
CN115803824A (zh) 2020-05-13 2023-03-14 朱诺治疗学股份有限公司 鉴定与临床反应相关的特征的方法及其用途
EP4340946A4 (en) * 2021-06-28 2025-04-23 Meridian Therapeutics, Inc. Compositions and methods for treating plasma cell diseases, including multiple myeloma, with a vaccine composition and myeloma-specific CAR-T cells
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