MX2024000151A - Composiciones y usos de las mismas para el tratamiento de afecciones malignas de celulas t usando terapias de celulas adoptivas. - Google Patents
Composiciones y usos de las mismas para el tratamiento de afecciones malignas de celulas t usando terapias de celulas adoptivas.Info
- Publication number
- MX2024000151A MX2024000151A MX2024000151A MX2024000151A MX2024000151A MX 2024000151 A MX2024000151 A MX 2024000151A MX 2024000151 A MX2024000151 A MX 2024000151A MX 2024000151 A MX2024000151 A MX 2024000151A MX 2024000151 A MX2024000151 A MX 2024000151A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- treatment
- cll
- subjects
- cell
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 230000003211 malignant effect Effects 0.000 title abstract 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 229960000390 fludarabine Drugs 0.000 abstract 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan composiciones de terapia de célula adoptiva y usos de los mismos que implican dosis de células adaptadas para ser administrables para tratar afecciones malignas de células B. Las células que expresan en general receptores recombinantes tal como receptores de antígeno quiméricos (CARs). En algunas modalidades, las composiciones y sus usos son para el tratamiento de CLL en sujetos con leucemia linfocítica crónica (CLL). En algunas modalidades, las composiciones y sus usos son para el tratamiento de CLL en sujetos con linfoma no de Hodgkin (NHL). En algunas modalidades, las composiciones y su usos implican una terapia reductora de linfocitos previa, tal como fludarabina adaptada par ser administrada previamente y/u otro agente quimioterapéutico reductor de linfocitos, por ejemplo ciclofosfamida. En algunas modalidades, las características de las composiciones y sus usos incluyen un incremento en la remisión completa, supervivencia total y/o supervivencia sin progresión de sujetos de acuerdo con los métodos proporcionados.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346547P | 2016-06-06 | 2016-06-06 | |
| US201662417292P | 2016-11-03 | 2016-11-03 | |
| US201662429737P | 2016-12-03 | 2016-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024000151A true MX2024000151A (es) | 2024-01-23 |
Family
ID=59227902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014911A MX2018014911A (es) | 2016-06-06 | 2017-06-06 | Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. |
| MX2024000151A MX2024000151A (es) | 2016-06-06 | 2018-11-30 | Composiciones y usos de las mismas para el tratamiento de afecciones malignas de celulas t usando terapias de celulas adoptivas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014911A MX2018014911A (es) | 2016-06-06 | 2017-06-06 | Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200016199A1 (es) |
| EP (1) | EP3463437A2 (es) |
| JP (3) | JP7139318B2 (es) |
| KR (3) | KR102644950B1 (es) |
| CN (1) | CN109562151A (es) |
| AU (1) | AU2017277396B2 (es) |
| BR (1) | BR112018074406A2 (es) |
| CA (1) | CA3024725A1 (es) |
| MA (1) | MA45341A (es) |
| MX (2) | MX2018014911A (es) |
| WO (1) | WO2017214207A2 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2964941A1 (en) | 2014-10-20 | 2016-04-28 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
| CA2973964A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| MX2018009011A (es) | 2016-02-02 | 2018-11-19 | Hutchinson Fred Cancer Res | Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos. |
| JP2019532997A (ja) * | 2016-11-03 | 2019-11-14 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法とｂｔｋ阻害剤との併用療法 |
| MX2019006288A (es) | 2016-12-03 | 2020-10-01 | Juno Therapeutics Inc | Metodos y composiciones para el uso de celulas t terapeuticas en combinacion con inhibidores de quinasa. |
| EP4353818A3 (en) | 2017-02-27 | 2024-06-19 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
| KR102771581B1 (ko) | 2017-03-14 | 2025-02-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | 극저온 보관 방법 |
| CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
| EP3678690A1 (en) | 2017-09-06 | 2020-07-15 | Fred Hutchinson Cancer Research Center | Methods for improving adoptive cell therapy |
| KR102742741B1 (ko) | 2017-10-18 | 2024-12-16 | 프레시전 인코포레이티드 | 스페이서를 포함하는 폴리펩타이드 조성물 |
| PT3703750T (pt) | 2017-11-01 | 2025-01-17 | Memorial Sloan Kettering Cancer Center | Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes |
| WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| EP3704230B1 (en) | 2017-11-01 | 2024-10-23 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US20210145882A1 (en) * | 2018-04-13 | 2021-05-20 | Fred Hutchinson Cancer Research Center | Methods for adoptive cell therapy targeting ror1 |
| US20210121466A1 (en) * | 2018-05-03 | 2021-04-29 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| EP3833742A2 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| US20210401887A1 (en) * | 2018-10-31 | 2021-12-30 | The Children's Hospital Of Philadelphia | T cells from lymphatic fluid for diagnostic and therapeutic use |
| IL282886B2 (en) | 2018-11-08 | 2025-07-01 | Juno Therapeutics Inc | Methods and combinations for T-cell therapy and modulation |
| EP3886894B1 (en) * | 2018-11-30 | 2024-03-13 | Juno Therapeutics, Inc. | Methods for dosing and treatment of b cell malignancies in adoptive cell therapy |
| WO2020113194A2 (en) * | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| CA3131533A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN111825769B (zh) * | 2019-04-16 | 2022-03-25 | 上海科技大学 | 一种泛素化缺失的嵌合抗原受体及其用途 |
| MA56388A (fr) * | 2019-06-27 | 2022-05-04 | Crispr Therapeutics Ag | Utilisation de lymphocytes t récepteurs d'antigènes chimériques et d'inhibiteurs de cellules nk pour le traitement du cancer |
| MX2022006715A (es) * | 2019-12-06 | 2022-09-23 | Juno Therapeutics Inc | Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b. |
| US20230071910A1 (en) * | 2020-01-24 | 2023-03-09 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
| EP4103204A1 (en) * | 2020-02-12 | 2022-12-21 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| WO2021236564A2 (en) * | 2020-05-18 | 2021-11-25 | Robert Sackstein | Compositions and methods for treatment of inflammatory disorders |
| TW202210084A (zh) * | 2020-06-05 | 2022-03-16 | 新加坡商泰莎治療有限公司 | Cd30陽性癌症之治療 |
| EP4171585A1 (en) * | 2020-06-26 | 2023-05-03 | CRISPR Therapeutics AG | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| AU2021366431A1 (en) * | 2020-10-20 | 2023-05-18 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| RU2758126C1 (ru) * | 2021-04-02 | 2021-10-26 | федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации | Способ прогнозирования развития рецидива диффузной В-крупноклеточной лимфомы |
| AU2022261141A1 (en) * | 2021-04-23 | 2023-11-30 | Myeloid Therapeutics, Inc. | Compositions and methods for conditioning patients for cell therapy |
| TW202307210A (zh) * | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Ｃｄ１９和ｃｄ２２嵌合抗原受體及其用途 |
| WO2025006561A2 (en) * | 2023-06-27 | 2025-01-02 | Nkarta, Inc. | Methods for treatment using cd19-directed immunotherapies |
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-
0
- MA MA045341A patent/MA45341A/fr unknown
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2017
- 2017-06-06 WO PCT/US2017/036231 patent/WO2017214207A2/en not_active Ceased
- 2017-06-06 CN CN201780046873.8A patent/CN109562151A/zh active Pending
- 2017-06-06 KR KR1020237018556A patent/KR102644950B1/ko active Active
- 2017-06-06 CA CA3024725A patent/CA3024725A1/en active Pending
- 2017-06-06 MX MX2018014911A patent/MX2018014911A/es unknown
- 2017-06-06 KR KR1020247007298A patent/KR20240036704A/ko active Pending
- 2017-06-06 JP JP2019516103A patent/JP7139318B2/ja active Active
- 2017-06-06 BR BR112018074406-9A patent/BR112018074406A2/pt unknown
- 2017-06-06 KR KR1020197000351A patent/KR102540751B1/ko active Active
- 2017-06-06 US US16/307,462 patent/US20200016199A1/en not_active Abandoned
- 2017-06-06 EP EP17733663.3A patent/EP3463437A2/en not_active Withdrawn
- 2017-06-06 AU AU2017277396A patent/AU2017277396B2/en not_active Ceased
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2018
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2023
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3463437A2 (en) | 2019-04-10 |
| KR20190026740A (ko) | 2019-03-13 |
| MA45341A (fr) | 2019-04-10 |
| JP2022033929A (ja) | 2022-03-02 |
| US20200016199A1 (en) | 2020-01-16 |
| JP2019517589A (ja) | 2019-06-24 |
| US20250197471A1 (en) | 2025-06-19 |
| KR20240036704A (ko) | 2024-03-20 |
| JP7139318B2 (ja) | 2022-09-20 |
| KR20230085947A (ko) | 2023-06-14 |
| MX2018014911A (es) | 2019-08-12 |
| CA3024725A1 (en) | 2017-12-14 |
| KR102540751B1 (ko) | 2023-06-09 |
| KR102644950B1 (ko) | 2024-03-11 |
| BR112018074406A2 (pt) | 2019-03-06 |
| AU2017277396A1 (en) | 2018-11-29 |
| CN109562151A (zh) | 2019-04-02 |
| WO2017214207A3 (en) | 2018-01-18 |
| AU2017277396B2 (en) | 2024-08-01 |
| WO2017214207A2 (en) | 2017-12-14 |
| JP2023184646A (ja) | 2023-12-28 |
| WO2017214207A8 (en) | 2018-11-29 |
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