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MX2017005698A - Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas. - Google Patents

Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.

Info

Publication number
MX2017005698A
MX2017005698A MX2017005698A MX2017005698A MX2017005698A MX 2017005698 A MX2017005698 A MX 2017005698A MX 2017005698 A MX2017005698 A MX 2017005698A MX 2017005698 A MX2017005698 A MX 2017005698A MX 2017005698 A MX2017005698 A MX 2017005698A
Authority
MX
Mexico
Prior art keywords
cell
tcr
modified
nucleic acid
gene expression
Prior art date
Application number
MX2017005698A
Other languages
English (en)
Inventor
Xiaojun Liu
Carl H June
Zhao Yangbing
Ren Jiangtao
Original Assignee
Univ Pennsylvania
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55858177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017005698(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2017005698A publication Critical patent/MX2017005698A/es

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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

La presente invención está relacionada a composiciones y métodos para generar una célula T modificada con un ácido nucleico capaz de regular a la baja la expresión genética endógena de un gen seleccionado del grupo que consiste en una cadena TCR a, una cadena TCR ß, beta-2 microglobulina, una molécula HLA, CTLA-4, PD1, y FAS y adicionalmente comprende un ácido nucleico que codifica para un receptor de células T modificado (TCR) que comprende afinidad para un antígeno de superficie sobre una célula objetivo o un ácido nucleico electroporado que codifica para un receptor de antígeno quimérico (CAR); también incluidos están métodos y composiciones farmacéuticas que comprenden la célula T modificada para terapia adoptiva y tratar una condición, tal como una enfermedad autoinmune.
MX2017005698A 2014-10-31 2015-10-15 Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas. MX2017005698A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462073651P 2014-10-31 2014-10-31
PCT/US2015/055799 WO2016069283A1 (en) 2014-10-31 2015-10-15 Altering gene expression in cart cells and uses thereof

Publications (1)

Publication Number Publication Date
MX2017005698A true MX2017005698A (es) 2017-06-29

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MX2017005698A MX2017005698A (es) 2014-10-31 2015-10-15 Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.
MX2023004169A MX2023004169A (es) 2014-10-31 2017-04-28 Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.

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US (7) US20170335331A1 (es)
EP (4) EP4427809A3 (es)
JP (5) JP2018500006A (es)
KR (5) KR102546296B1 (es)
CN (3) CN107206024B (es)
AU (4) AU2015339743C1 (es)
BR (1) BR112017008693A2 (es)
CA (2) CA2964948A1 (es)
EA (1) EA201790953A1 (es)
ES (1) ES2983094T3 (es)
MX (2) MX2017005698A (es)
PL (1) PL3215166T3 (es)
WO (2) WO2016069282A1 (es)

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AU2024203330A1 (en) 2024-08-08
AU2015339744A1 (en) 2017-04-27
AU2021200118A1 (en) 2021-03-25
MX2023004169A (es) 2023-05-03
JP2023037006A (ja) 2023-03-14
JP7657474B2 (ja) 2025-04-07
EP3215166A4 (en) 2018-12-05
US20170335331A1 (en) 2017-11-23
KR102546296B1 (ko) 2023-06-21
ES2983094T3 (es) 2024-10-21
EP3215168A4 (en) 2018-08-15
EP4219725A3 (en) 2023-08-30
CN114836385B (zh) 2025-04-04
CN107206024B (zh) 2021-12-03
CN107206024A (zh) 2017-09-26
EP3215166B1 (en) 2024-04-24
CA2964948A1 (en) 2016-05-06
KR20230098910A (ko) 2023-07-04
WO2016069283A1 (en) 2016-05-06
CN114836385A (zh) 2022-08-02
US11208661B2 (en) 2021-12-28
CN107249606A (zh) 2017-10-13
EP3215168A1 (en) 2017-09-13
JP2017535261A (ja) 2017-11-30

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