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MX2018013565A - Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales. - Google Patents

Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales.

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Publication number
MX2018013565A
MX2018013565A MX2018013565A MX2018013565A MX2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A
Authority
MX
Mexico
Prior art keywords
cells
methods
myeloid leukemia
natural killer
acute myeloid
Prior art date
Application number
MX2018013565A
Other languages
English (en)
Inventor
Kang Lin
Voskinarian-Berse Vanessa
Herzberg Uri
Murphy Brian
Zhang Xiaokui
Hussein Mohamed
Myint Han
Wilson Keith
Nordberg Andrea
Alan Fischkoff Steven
Original Assignee
Celularity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Celularity Inc filed Critical Celularity Inc
Publication of MX2018013565A publication Critical patent/MX2018013565A/es

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

En la presente se proporcionan métodos para tratar la leucemia mieloide aguda (AML, por sus siglas en inglés) y el mieloma múltiple (MM) mediante la administración de una cantidad efectiva de una población celular que comprende células asesinas naturales, en donde la población celular que comprende células asesinas naturales se produce mediante un método de tres etapas que comprende el cultivo una población de células madre o progenitoras hematopoyéticas en medios que comprenden factores de movilización de células madre, por ejemplo, métodos de tres etapas para producir células NK en medios que comprenden factores de movilización de células madre que comienzan con células madre o progenitoras hematopoyéticas de células de la placenta, por ejemplo, a partir de perfusión placentaria (por ejemplo, perfusión placentaria humana) u otros tejidos, por ejemplo, sangre del cordón umbilical o sangre periférica. Además, en la presente se proporcionan métodos para usar las células NK producidas por los métodos de tres etapas que se proporcionan en la presente para suprimir la proliferación de células de leucemia mieloide aguda. En ciertas modalidades, las células NK producidas por los métodos de tres etapas descritos en el presente documento se usan en combinación con IL-2.
MX2018013565A 2016-05-07 2017-05-05 Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales. MX2018013565A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662333187P 2016-05-07 2016-05-07
US201662333186P 2016-05-07 2016-05-07
US201662415954P 2016-11-01 2016-11-01
US201662415918P 2016-11-01 2016-11-01
PCT/US2017/031255 WO2017196657A1 (en) 2016-05-07 2017-05-05 Methods of treating acute myeloid leukemia and multiple myeloma using natural killer cells

Publications (1)

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MX2018013565A true MX2018013565A (es) 2019-08-21

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US (1) US11180731B2 (es)
EP (1) EP3452063A4 (es)
JP (2) JP2019519486A (es)
KR (1) KR20190005964A (es)
CN (1) CN109843304A (es)
AU (2) AU2017262581A1 (es)
BR (1) BR112018072701A2 (es)
CA (1) CA3023239A1 (es)
CO (1) CO2018012923A2 (es)
IL (1) IL262775A (es)
MX (1) MX2018013565A (es)
NZ (1) NZ747910A (es)
SG (2) SG11201809858RA (es)
WO (1) WO2017196657A1 (es)
ZA (1) ZA201807431B (es)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
MX2018004600A (es) * 2015-10-15 2019-09-04 Celularity Inc Celulas aniquiladoras naturales y células ilc3 y usos de las mismas.
EP3746095A4 (en) * 2018-02-01 2021-04-21 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
US20220265712A1 (en) * 2019-06-14 2022-08-25 Celularity Inc. Populations of natural killer cells for treating cancers
CN111727961B (zh) * 2020-08-10 2020-12-01 医微细胞生物技术(广州)有限公司 一种牙髓干细胞冻存液及其冻存方法
EP4251741A1 (en) 2020-11-30 2023-10-04 CRISPR Therapeutics AG Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
CN114015653A (zh) * 2021-12-15 2022-02-08 山东省齐鲁干细胞工程有限公司 一种冻存脐带血来源的nk细胞及其制备方法
CN117164593A (zh) * 2023-08-31 2023-12-05 贵州省天然产物研究中心 一种嘧啶并吲哚类化合物及其制备方法和应用、抗红白血病药物

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JPH07135969A (ja) * 1993-11-18 1995-05-30 Rikagaku Kenkyusho ナチュラルキラー細胞の前駆細胞及びその分化増殖法
PE20100362A1 (es) * 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
DK2686421T3 (da) 2011-03-18 2021-03-08 Glycostem Therapeutics B V Generering af nk-celler og nk-celleforløbere
DK2807165T3 (da) * 2012-01-27 2019-07-15 Univ Montreal Pyrimido[4,5-b]indol-derivater og anvendelse deraf i ekspansionen af hæmatopoietiske stamceller
PL2812011T3 (pl) 2012-02-08 2020-06-29 Glycostem Therapeutics B.V. Różnicowanie komórek NK z komórek hematopoetycznych CD34<sup>+</sup> ex vivo
RU2015108761A (ru) * 2012-08-13 2016-10-10 Антродженезис Корпорейшн Природные клетки-киллеры и их применение
KR20210014210A (ko) 2014-05-15 2021-02-08 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도

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AU2017262581A1 (en) 2019-01-03
BR112018072701A2 (pt) 2019-02-19
ZA201807431B (en) 2021-09-29
AU2022287584A1 (en) 2023-02-02
SG10201912837RA (en) 2020-02-27
JP2022095927A (ja) 2022-06-28
WO2017196657A1 (en) 2017-11-16
JP2019519486A (ja) 2019-07-11
CO2018012923A2 (es) 2018-12-14
NZ747910A (en) 2023-02-24
US20190153389A1 (en) 2019-05-23
CA3023239A1 (en) 2017-11-16
EP3452063A1 (en) 2019-03-13
IL262775A (en) 2018-12-31
KR20190005964A (ko) 2019-01-16
EP3452063A4 (en) 2020-01-08
CN109843304A (zh) 2019-06-04
US11180731B2 (en) 2021-11-23
SG11201809858RA (en) 2018-12-28

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