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MX2018013332A - Conjugados de pirrolobenzodiazepina diana. - Google Patents

Conjugados de pirrolobenzodiazepina diana.

Info

Publication number
MX2018013332A
MX2018013332A MX2018013332A MX2018013332A MX2018013332A MX 2018013332 A MX2018013332 A MX 2018013332A MX 2018013332 A MX2018013332 A MX 2018013332A MX 2018013332 A MX2018013332 A MX 2018013332A MX 2018013332 A MX2018013332 A MX 2018013332A
Authority
MX
Mexico
Prior art keywords
pyrrolobenzodiazapine
conjugates
targeted
pbds
conjugate
Prior art date
Application number
MX2018013332A
Other languages
English (en)
Inventor
Philip Wilson Howard
Scott Jeffrey
Peter Senter
Patrick Burke
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2018013332A publication Critical patent/MX2018013332A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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Abstract

Se proporcionan Conjugados que comprenden conjugados de PBD a un agente diana y procedimientos de uso de dichos PBD.
MX2018013332A 2010-04-15 2012-10-12 Conjugados de pirrolobenzodiazepina diana. MX2018013332A (es)

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MX2016002200A MX391454B (es) 2010-04-15 2011-04-15 Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
MX2012011900A MX2012011900A (es) 2010-04-15 2011-04-15 Conjugados de pirrolobenzodiazepina diana.
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