[go: up one dir, main page]

MX2018006434A - Metodo para producir l-metionina. - Google Patents

Metodo para producir l-metionina.

Info

Publication number
MX2018006434A
MX2018006434A MX2018006434A MX2018006434A MX2018006434A MX 2018006434 A MX2018006434 A MX 2018006434A MX 2018006434 A MX2018006434 A MX 2018006434A MX 2018006434 A MX2018006434 A MX 2018006434A MX 2018006434 A MX2018006434 A MX 2018006434A
Authority
MX
Mexico
Prior art keywords
methionine
producing
homoserine
microorganism
cultured
Prior art date
Application number
MX2018006434A
Other languages
English (en)
Inventor
Fischer Daniel
Bathe Brigitte
HASSELMEYER Marleen
Ochrombel Ines
Hampel Michael
Pedall Joanne
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of MX2018006434A publication Critical patent/MX2018006434A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01031—Homoserine O-acetyltransferase (2.3.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01049—O-acetylhomoserine aminocarboxypropyltransferase (2.5.1.49)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona con un método para producir L-metionina en el cual se realiza el cultivo de un microorganismo en presencia de L-homoserina y mercaptano de metilo, una sal de los mismos o disulfuro de dimetilo, mediante lo cual la L-metionina es acumulada en el medio de cultivo.
MX2018006434A 2015-11-27 2016-11-01 Metodo para producir l-metionina. MX2018006434A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15196776 2015-11-27
PCT/EP2016/076281 WO2017089077A1 (en) 2015-11-27 2016-11-01 Method for producing l-methionine

Publications (1)

Publication Number Publication Date
MX2018006434A true MX2018006434A (es) 2018-09-28

Family

ID=54705525

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006434A MX2018006434A (es) 2015-11-27 2016-11-01 Metodo para producir l-metionina.

Country Status (11)

Country Link
US (1) US11034985B2 (es)
EP (1) EP3380627B1 (es)
KR (1) KR102771842B1 (es)
CN (1) CN108291243A (es)
AR (1) AR106834A1 (es)
ES (1) ES2748226T3 (es)
MX (1) MX2018006434A (es)
MY (1) MY186059A (es)
PL (1) PL3380627T3 (es)
RU (1) RU2729012C2 (es)
WO (1) WO2017089077A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022207543A1 (en) 2021-04-01 2022-10-06 Evonik Operations Gmbh Enzymatic method for producing l-glufosinate and its phosphoesters
AR132026A1 (es) * 2023-03-01 2025-05-21 Hunan Lier Biotech Co Ltd Un proceso de preparación de l-metionina directamente a partir de l-homoserina

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH525863A (de) 1967-09-12 1972-07-31 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von L-Homoserin und L-Lysin
JPH07503855A (ja) 1992-02-20 1995-04-27 ジェネンコア　インターナショナル　インコーポレーテッド 硫黄の還元源を用いたメチオニンの生合成
US5795776A (en) 1994-03-22 1998-08-18 Bio-Technology General Corp. Expression plasmids regulated by an OSMB promoter
JP4035855B2 (ja) 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
JP2000157267A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
EP1307475A1 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
DE10109690A1 (de) 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
US6812016B2 (en) * 2000-09-02 2004-11-02 Degussa Ag Nucleotide sequences which code for the metY gene
CN100334213C (zh) * 2000-12-22 2007-08-29 巴斯福股份公司 棒状杆菌基因
DE10303571A1 (de) 2003-01-30 2004-08-12 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
CN101208427A (zh) * 2003-05-30 2008-06-25 米克罗比亚股份有限公司 氨基酸制备的方法和组合物
DE10359594A1 (de) 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
KR100651220B1 (ko) 2004-06-29 2006-11-29 씨제이 주식회사 Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
DE102004035065A1 (de) 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
RU2413001C2 (ru) * 2005-07-18 2011-02-27 Эвоник Дегусса Гмбх Применение диметилдисульфида для продукции метионина микроорганизмами
CN101223280B (zh) * 2005-07-18 2013-05-15 赢创德固赛有限公司 二甲基二硫醚在微生物中用于甲硫氨酸生产
KR20080036608A (ko) * 2005-07-18 2008-04-28 바스프 에스이 메티오닌 생산 재조합 미생물
US7445879B2 (en) 2005-08-23 2008-11-04 Nukote International, Inc. Preparation of suspension polymerized toners
US8389250B2 (en) 2006-01-04 2013-03-05 Metabolic Explorer Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine
DE102006004063A1 (de) * 2006-01-28 2007-08-02 Degussa Gmbh Verfahren zur Herstellung von Methionin aus Homoserin
KR100905381B1 (ko) * 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
CN101641446A (zh) 2007-03-23 2010-02-03 代谢探索者公司 通过进化和理性设计的组合获得的用于产生1，2-丙二醇的新微生物
WO2008127240A1 (en) 2007-04-11 2008-10-23 Cargill, Incorporated Compositions and methods of producing methionine
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US9005952B2 (en) 2008-04-04 2015-04-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
KR101136289B1 (ko) * 2008-04-04 2012-04-20 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 이를 이용한 ｌ-메치오닌 전구체의 생산 방법
WO2010020290A1 (en) 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
KR101048593B1 (ko) * 2009-02-27 2011-07-12 씨제이제일제당 (주) 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법
US8609396B2 (en) 2009-08-28 2013-12-17 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
US8283152B2 (en) 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
WO2011073738A1 (en) 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
KR101770123B1 (ko) 2009-12-30 2017-08-23 에보니크 데구사 게엠베하 숙시네이트 데히드로게나제의 과다발현에 의한 메티오닌 생산의 증가
CN102782137B (zh) 2009-12-30 2016-01-06 代谢探索者公司 用于甲硫氨酸生产的菌株和方法
AR083468A1 (es) 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
PL2657250T3 (pl) 2010-12-21 2018-02-28 Cj Cheiljedang Corporation Odmiana polipeptydu posiadającego aktywność acetylotransferazy homoseryny oraz mikroorganizm wyrażający to samo
EP2479279A1 (de) 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
SG2014010441A (en) * 2011-09-02 2014-08-28 Arkema France Preparation process of l-methionine
EP2861726B1 (en) 2012-06-18 2017-05-31 Evonik Degussa GmbH Recombinant microorganism for the fermentative production of methionine
JP2016529900A (ja) 2013-08-30 2016-09-29 メタボリック エクスプローラー メチオニン流出が強化された、メチオニン生産のための微生物
BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
RU2702416C2 (ru) 2014-04-30 2019-10-08 Эвоник Дегусса Гмбх Способ получения l-аминокислот с помощью алкалифильной бактерии
EP2940039A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems
WO2016034536A1 (en) 2014-09-01 2016-03-10 Metabolic Explorer Method and microorganism for methionine production by fermentation with improved methionine efflux
CN108026516A (zh) 2015-08-07 2018-05-11 赢创德固赛有限公司 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine

Also Published As

Publication number Publication date
EP3380627A1 (en) 2018-10-03
RU2729012C2 (ru) 2020-08-03
RU2018123145A (ru) 2019-12-30
WO2017089077A1 (en) 2017-06-01
CN108291243A (zh) 2018-07-17
AR106834A1 (es) 2018-02-21
BR112018010747A2 (pt) 2018-11-21
EP3380627B1 (en) 2019-08-14
KR20180086240A (ko) 2018-07-30
ES2748226T3 (es) 2020-03-16
MY186059A (en) 2021-06-17
KR102771842B1 (ko) 2025-02-21
US11034985B2 (en) 2021-06-15
PL3380627T3 (pl) 2020-01-31
RU2018123145A3 (es) 2020-02-28
US20180346946A1 (en) 2018-12-06
BR112018010747A8 (pt) 2019-02-26

Similar Documents

Publication Publication Date Title
BR112017007770A2 (pt) cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
AR102049A1 (es) Microorganismo que produce o-fosfoserina y un procedimiento para la producción de o-fosfoserina o l-cisteína por el uso del mismo
PH12018500130A1 (en) Protein-rich biomass of thraustochytrids, culturing method, and uses
SG10201807693YA (en) Methods for recombinant production of saffron compounds
SG10201806655TA (en) Microorganism producing o-acetyl-homoserine and method for producing o-acetylhomoserine using the same
MY193225A (en) Methods for continuous production of products from microorganisms
PH12018500150A1 (en) Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them
BR112016030948A2 (pt) Método para simulação do tempo necessário para executar uma operação marítima restrita ao clima
EA201600026A1 (ru) Бактериальная гиалуронидаза и способ ее производства
PH12020551791A1 (en) Methods for the production of methacrylates
MX2018014764A (es) Metodo para producir acido 3-hidroxiadipico.
MX2015017414A (es) Bacteria acetogenica.
BR112016025999A2 (pt) micro-organismo tendo produtividade de l-lisina aperfeiçoada e método para produção de l-lisina usando o mesmo
UA117372C2 (uk) Композиція та спосіб поліпшення продуктивності рослин
PH12018500542A1 (en) Novel variant of o-phosphoserine exporter and method of producing o-phosphoserine, cysteine, and its derivatives using the same
MX2018014769A (es) Metodo para producir acido a-hidromuconico.
PH12018500069A1 (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MY174840A (en) Microorganism producing o-acetyl-homoserine, and method for producing o-acetyl-homoserine by using same
MY186059A (en) Method for producing l-methionine
BR112018006044A2 (pt) método de produção de mercaptanos por hidrogenólise enzimática de dissulfetos
MY195206A (en) Microorganisms For Production of O-Succinylhomoserine and Method for Production of O-Succinylhomoserine Using the Same
EA038364B9 (ru) Способ получения гидролизата биомассы с пониженным содержанием солей
MX382437B (es) Método fermentativo para blanquear biomasa de chlorella protothecoides.
SA518391158B1 (ar) طريقة لإنتاج مركبتانات عن طريق التحلل الهيدروجيني لأنزيم ثنائي السلفيد بوجود الهيدروجين
WO2018093154A3 (ko) 카이스티아 속 미생물을 이용한 d-사이코스 제조방법

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: UNILEVER IP HOLDINGS B.V.