MX2018004289A - Receptores de antigenos quimericos dirigidos a psca. - Google Patents
Receptores de antigenos quimericos dirigidos a psca.Info
- Publication number
- MX2018004289A MX2018004289A MX2018004289A MX2018004289A MX2018004289A MX 2018004289 A MX2018004289 A MX 2018004289A MX 2018004289 A MX2018004289 A MX 2018004289A MX 2018004289 A MX2018004289 A MX 2018004289A MX 2018004289 A MX2018004289 A MX 2018004289A
- Authority
- MX
- Mexico
- Prior art keywords
- psca
- receivers
- antigens directed
- chemical antigens
- directed
- Prior art date
Links
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 title abstract 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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Abstract
Se describen inmunorreceptores de transmembrana quiméricos (CAR) dirigidos a PSCA.
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| US201562238062P | 2015-10-06 | 2015-10-06 | |
| PCT/US2016/055761 WO2017062628A1 (en) | 2015-10-06 | 2016-10-06 | Chimeric antigen receptors targeted to psca |
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| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| CN109306013B (zh) * | 2017-07-26 | 2020-09-25 | 重庆精准生物技术有限公司 | 抗cd20抗原的嵌合抗原受体及其应用 |
| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体 |
| CA3089051A1 (en) | 2018-01-22 | 2019-07-25 | Endocyte, Inc. | Methods of use for car t cells |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| JPWO2020004337A1 (ja) * | 2018-06-27 | 2021-08-02 | 国立大学法人東海国立大学機構 | Cd37特異的キメラ抗原レセプター |
| US20210177903A1 (en) * | 2018-08-07 | 2021-06-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Car t-cells for the treatment of bone metastatic cancer |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| WO2020191336A1 (en) | 2019-03-21 | 2020-09-24 | Yamaguchi, Yukiko | Composition and method for reducing expression of checkpoint inhibitors in t cells expressing a car or ctl |
| CN114729059A (zh) * | 2019-09-11 | 2022-07-08 | 宾夕法尼亚大学董事会 | 包含前列腺干细胞抗原(psca)嵌合抗原受体(cars)的组合物和方法 |
| CN111097043B (zh) * | 2020-01-13 | 2023-07-04 | 广东昭泰体内生物医药科技有限公司 | 一种胃癌药物组合物及其应用 |
| CN117843812A (zh) * | 2020-05-22 | 2024-04-09 | 重庆精准生物技术有限公司 | 逆转肿瘤微环境的融合蛋白及其应用 |
| US20230405122A1 (en) * | 2020-11-24 | 2023-12-21 | City Of Hope | Compositions and uses of psca targeted chimeric antigen receptor modified cells |
| WO2022140159A1 (en) | 2020-12-24 | 2022-06-30 | Kite Pharma, Inc. | Prostate cancer chimeric antigen receptors |
| CN117242090A (zh) | 2021-03-30 | 2023-12-15 | 希望之城公司 | CAR T细胞疗法和IFNγ |
| KR20240157693A (ko) | 2022-03-10 | 2024-11-01 | 시티 오브 호프 | 세포 면역요법을 위한 막-결합 il-12 |
| WO2025235801A1 (en) | 2024-05-08 | 2025-11-13 | City Of Hope | Antibodies targeted to osteopontin and uses thereof for reducing resistance of solid tumors immune cell therapy |
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| EP1641827A2 (en) | 2003-06-27 | 2006-04-05 | Biogen Idec MA Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| EP2428522A1 (en) | 2004-05-28 | 2012-03-14 | Agensys, Inc. | Antibodies that bind to PSCA proteins for diagnosis of cancer |
| US20080131415A1 (en) * | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| US8940298B2 (en) * | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR102264290B1 (ko) * | 2012-08-20 | 2021-06-10 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법을 위한 방법 및 조성물 |
| ES2918458T3 (es) * | 2012-10-03 | 2022-07-15 | Diamond Innovations Inc | Proceso para la preparación de partículas de nitruro de boro cúbico |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| MX389160B (es) * | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| CN113307880B (zh) * | 2014-01-13 | 2025-07-04 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| CA2937750A1 (en) * | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
| AU2015243927B2 (en) * | 2014-04-10 | 2021-09-02 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Method and compositions for cellular immunotherapy |
| AU2016222887B2 (en) * | 2015-02-24 | 2022-07-14 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
| MX2018001566A (es) * | 2015-08-07 | 2019-04-25 | Imaginab Inc | Construcciones de union a antigeno para moleculas diana. |
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| IL258502B2 (en) | 2023-05-01 |
| JP6985256B2 (ja) | 2021-12-22 |
| EP3747462A1 (en) | 2020-12-09 |
| US20200308300A1 (en) | 2020-10-01 |
| BR112018006991A2 (en) | 2018-10-16 |
| JP2018530333A (ja) | 2018-10-18 |
| CA3001230A1 (en) | 2017-04-13 |
| HK1258517A1 (zh) | 2019-11-15 |
| RU2021132734A (ru) | 2022-04-25 |
| CN115074331B (zh) | 2024-05-17 |
| US20230348617A1 (en) | 2023-11-02 |
| RU2759879C2 (ru) | 2021-11-18 |
| EP3359574B1 (en) | 2020-04-22 |
| US11466097B2 (en) | 2022-10-11 |
| AU2016336515B2 (en) | 2023-08-24 |
| WO2017062628A1 (en) | 2017-04-13 |
| IL258502B1 (en) | 2023-01-01 |
| IL258502A (en) | 2018-05-31 |
| JP7297854B2 (ja) | 2023-06-26 |
| CN108290956A (zh) | 2018-07-17 |
| RU2018113510A3 (es) | 2020-03-17 |
| CN108290956B (zh) | 2022-07-05 |
| EP3359574A1 (en) | 2018-08-15 |
| AU2016336515A1 (en) | 2018-04-26 |
| JP2022043056A (ja) | 2022-03-15 |
| ES2809550T3 (es) | 2021-03-04 |
| KR20180056770A (ko) | 2018-05-29 |
| RU2018113510A (ru) | 2019-11-07 |
| CN115074331A (zh) | 2022-09-20 |
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