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MX2018005193A - Proteinas de doble funcion y composicion farmaceutica que comprende las mismas. - Google Patents

Proteinas de doble funcion y composicion farmaceutica que comprende las mismas.

Info

Publication number
MX2018005193A
MX2018005193A MX2018005193A MX2018005193A MX2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A
Authority
MX
Mexico
Prior art keywords
protein
dual function
pharmaceutical composition
same
present
Prior art date
Application number
MX2018005193A
Other languages
English (en)
Inventor
Hwan Kim Jun
LIM Seyoung
Seo Minji
Ho Choi Hyun
Kim Dohoon
Kyeong JU Mi
Young PARK Ju-
Gyun KIM Jong
Youn Nam Su
Gi Kim Seul
LIM Sangmyoun
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of MX2018005193A publication Critical patent/MX2018005193A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención provee una proteí­na de doble función preparada uniendo una proteí­na biológicamente activa y una proteí­na mutante de FGF a una región Fc de una inmunoglobulina, que tiene una eficacia farmacológica, duración in vivo y estabilidad proteica mejoradas. Una proteí­na de doble función de conformidad con la presente invención presenta eficacia farmacológica, duración in vivo y estabilidad proteica mejoradas, y una composición farmacóutica que contiene la proteí­na de doble función como ingrediente activo puede usarse eficazmente como agente terapóutico para diabetes, obesidad, dislipidemia, sí­ndrome metabólico, enfermedades del hí­gado graso no alcohólico, esteatohepatitis no alcohólica o enfermedades cardiovasculares.
MX2018005193A 2015-10-28 2016-10-28 Proteinas de doble funcion y composicion farmaceutica que comprende las mismas. MX2018005193A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020150150576A KR102670157B1 (ko) 2015-10-28 2015-10-28 이중 작용 단백질 및 이를 포함하는 약학적 조성물
PCT/KR2016/012300 WO2017074123A1 (en) 2015-10-28 2016-10-28 Dual function proteins and pharmaceutical composition comprising same

Publications (1)

Publication Number Publication Date
MX2018005193A true MX2018005193A (es) 2018-07-06

Family

ID=58630627

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005193A MX2018005193A (es) 2015-10-28 2016-10-28 Proteinas de doble funcion y composicion farmaceutica que comprende las mismas.

Country Status (22)

Country Link
US (3) US11136364B2 (es)
EP (2) EP4527403A3 (es)
JP (3) JP7575862B2 (es)
KR (2) KR102670157B1 (es)
CN (4) CN115925978A (es)
AU (1) AU2016346870B2 (es)
BR (1) BR112018008805A8 (es)
CA (1) CA3003115C (es)
DK (1) DK3368555T3 (es)
ES (1) ES3013110T3 (es)
FI (1) FI3368555T3 (es)
HR (1) HRP20250309T1 (es)
HU (1) HUE071444T2 (es)
LT (1) LT3368555T (es)
MX (1) MX2018005193A (es)
PL (1) PL3368555T3 (es)
PT (1) PT3368555T (es)
RS (1) RS66648B1 (es)
RU (1) RU2741345C2 (es)
SI (1) SI3368555T1 (es)
WO (1) WO2017074123A1 (es)
ZA (1) ZA201802003B (es)

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Also Published As

Publication number Publication date
LT3368555T (lt) 2025-04-10
ES3013110T3 (en) 2025-04-11
EP3368555A4 (en) 2019-11-20
RS66648B1 (sr) 2025-04-30
BR112018008805A8 (pt) 2019-02-26
US20220002368A1 (en) 2022-01-06
KR102670157B1 (ko) 2024-05-29
JP2019500013A (ja) 2019-01-10
RU2018118025A (ru) 2019-11-28
EP3368555A1 (en) 2018-09-05
US20250270269A1 (en) 2025-08-28
BR112018008805A2 (en) 2018-10-30
WO2017074123A1 (en) 2017-05-04
CN116333160A (zh) 2023-06-27
AU2016346870A1 (en) 2018-05-10
CN115925979A (zh) 2023-04-07
NZ741439A (en) 2025-02-28
PL3368555T3 (pl) 2025-05-12
CN108350054B (zh) 2022-09-02
JP7575862B2 (ja) 2024-10-30
EP4527403A3 (en) 2025-09-24
ZA201802003B (en) 2019-05-29
HK1257373A1 (zh) 2019-10-18
EP4527403A2 (en) 2025-03-26
DK3368555T3 (da) 2025-04-14
KR20240078629A (ko) 2024-06-04
KR20170049320A (ko) 2017-05-10
CA3003115A1 (en) 2017-05-04
US11136364B2 (en) 2021-10-05
SI3368555T1 (sl) 2025-05-30
HUE071444T2 (hu) 2025-09-28
CN115925978A (zh) 2023-04-07
HRP20250309T1 (hr) 2025-04-25
EP3368555B1 (en) 2025-01-15
AU2016346870B2 (en) 2021-04-22
US20200024318A1 (en) 2020-01-23
JP2023011644A (ja) 2023-01-24
FI3368555T3 (fi) 2025-02-25
CN108350054A (zh) 2018-07-31
RU2018118025A3 (es) 2020-03-24
RU2741345C2 (ru) 2021-01-25
JP2025128179A (ja) 2025-09-02
PT3368555T (pt) 2025-02-28
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