MX2018005046A - Metodo para producir flutemetamol. - Google Patents
Metodo para producir flutemetamol.Info
- Publication number
- MX2018005046A MX2018005046A MX2018005046A MX2018005046A MX2018005046A MX 2018005046 A MX2018005046 A MX 2018005046A MX 2018005046 A MX2018005046 A MX 2018005046A MX 2018005046 A MX2018005046 A MX 2018005046A MX 2018005046 A MX2018005046 A MX 2018005046A
- Authority
- MX
- Mexico
- Prior art keywords
- flutemetamol
- labeled compound
- general formula
- predetermined general
- compound represented
- Prior art date
Links
- 229940113298 flutemetamol Drugs 0.000 title abstract 2
- VVECGOCJFKTUAX-UHFFFAOYSA-N 2-[3-fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol Chemical compound C1=C(F)C(NC)=CC=C1C1=NC2=CC=C(O)C=C2S1 VVECGOCJFKTUAX-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- VVECGOCJFKTUAX-HUYCHCPVSA-N flutemetamol ((18)F) Chemical compound C1=C([18F])C(NC)=CC=C1C1=NC2=CC=C(O)C=C2S1 VVECGOCJFKTUAX-HUYCHCPVSA-N 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000001044 reversed-phase solid-phase extraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Saccharide Compounds (AREA)
- Ink Jet (AREA)
Abstract
Se proporciona un método para producir flutemetamol que incluye las etapas de: hacer reaccionar un compuesto precursor representado por una fórmula general predeterminada con un fluoruro radioactivo para obtener un compuesto etiquetado 18F representado por una fórmula general predeterminada; permitir una base fuerte para actuar sobre la mezcla de reacción de la etapa de arriba que contiene el compuesto precursor y el compuesto etiquetado 18F; después de la etapa de arriba, purificar el compuesto etiquetado 18F utilizando un cartucho de extracción de fase sólida de fase inversa; y remover un grupo protector para obtener [18F]flutemetamol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015211413A JP6485914B2 (ja) | 2015-10-28 | 2015-10-28 | フルテメタモルの製造方法 |
| PCT/EP2016/074840 WO2017071980A1 (en) | 2015-10-28 | 2016-10-17 | Method for producing flutemetamol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018005046A true MX2018005046A (es) | 2018-06-13 |
| MX376470B MX376470B (es) | 2025-03-07 |
Family
ID=57144967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018005046A MX376470B (es) | 2015-10-28 | 2016-10-17 | Método para producir flutemetamol. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10472338B2 (es) |
| EP (1) | EP3368518B1 (es) |
| JP (1) | JP6485914B2 (es) |
| KR (1) | KR102668514B1 (es) |
| CN (1) | CN108137520B (es) |
| AU (1) | AU2016344537B2 (es) |
| CA (1) | CA2998985C (es) |
| ES (1) | ES2766474T3 (es) |
| IL (1) | IL258148B (es) |
| MX (1) | MX376470B (es) |
| RU (1) | RU2733398C2 (es) |
| WO (1) | WO2017071980A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6485914B2 (ja) | 2015-10-28 | 2019-03-20 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
| JP6770837B2 (ja) * | 2016-06-28 | 2020-10-21 | 日本メジフィジックス株式会社 | 放射性フッ素標識有機化合物を製造する方法 |
| US11318216B2 (en) | 2017-06-23 | 2022-05-03 | Nihon Medi-Physics Co., Ltd. | Method for producing radiohalogen-labeled compound and method for producing radiopharmaceutical |
| GB201805253D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Ltd Ip | Solid phase extraction |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1010280A3 (fr) * | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| WO2006133732A1 (en) * | 2005-06-17 | 2006-12-21 | Advanced Accelerator Applications | Process for synthesizing labelled compounds |
| GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
| EP2017258B1 (en) * | 2006-05-11 | 2012-03-14 | Nihon Medi-Physics Co., Ltd. | Process for production of radioactive fluorine-labeled organic compound |
| PL2182988T3 (pl) | 2007-08-30 | 2015-02-27 | Ge Healthcare Ltd | Kompozycja radiofarmaceutyczna |
| NZ600791A (en) * | 2009-10-08 | 2014-02-28 | Ge Healthcare Ltd | Solid phase extraction purification technique |
| JP6485914B2 (ja) | 2015-10-28 | 2019-03-20 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
-
2015
- 2015-10-28 JP JP2015211413A patent/JP6485914B2/ja active Active
-
2016
- 2016-10-17 CN CN201680062917.1A patent/CN108137520B/zh active Active
- 2016-10-17 RU RU2018113741A patent/RU2733398C2/ru active
- 2016-10-17 CA CA2998985A patent/CA2998985C/en active Active
- 2016-10-17 EP EP16782221.2A patent/EP3368518B1/en active Active
- 2016-10-17 AU AU2016344537A patent/AU2016344537B2/en active Active
- 2016-10-17 WO PCT/EP2016/074840 patent/WO2017071980A1/en not_active Ceased
- 2016-10-17 US US15/764,309 patent/US10472338B2/en active Active
- 2016-10-17 KR KR1020187011715A patent/KR102668514B1/ko active Active
- 2016-10-17 ES ES16782221T patent/ES2766474T3/es active Active
- 2016-10-17 MX MX2018005046A patent/MX376470B/es active IP Right Grant
-
2018
- 2018-03-15 IL IL258148A patent/IL258148B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016344537B2 (en) | 2020-09-17 |
| US20190055207A1 (en) | 2019-02-21 |
| IL258148A (en) | 2018-05-31 |
| RU2733398C2 (ru) | 2020-10-01 |
| AU2016344537A1 (en) | 2018-04-12 |
| BR112018007545A2 (pt) | 2018-10-23 |
| WO2017071980A1 (en) | 2017-05-04 |
| MX376470B (es) | 2025-03-07 |
| RU2018113741A (ru) | 2019-11-28 |
| RU2018113741A3 (es) | 2020-02-20 |
| KR102668514B1 (ko) | 2024-05-24 |
| IL258148B (en) | 2020-08-31 |
| EP3368518B1 (en) | 2019-12-04 |
| US10472338B2 (en) | 2019-11-12 |
| CN108137520A (zh) | 2018-06-08 |
| ES2766474T3 (es) | 2020-06-12 |
| CA2998985A1 (en) | 2017-05-04 |
| CN108137520B (zh) | 2022-06-21 |
| HK1249098A1 (zh) | 2018-10-26 |
| JP2017081847A (ja) | 2017-05-18 |
| KR20180073581A (ko) | 2018-07-02 |
| EP3368518A1 (en) | 2018-09-05 |
| JP6485914B2 (ja) | 2019-03-20 |
| CA2998985C (en) | 2023-10-31 |
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |