MX2019006959A - Procesos para la preparacion de compuestos de pirimidinilciclopentano. - Google Patents
Procesos para la preparacion de compuestos de pirimidinilciclopentano.Info
- Publication number
- MX2019006959A MX2019006959A MX2019006959A MX2019006959A MX2019006959A MX 2019006959 A MX2019006959 A MX 2019006959A MX 2019006959 A MX2019006959 A MX 2019006959A MX 2019006959 A MX2019006959 A MX 2019006959A MX 2019006959 A MX2019006959 A MX 2019006959A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- processes
- compounds
- pyrimidinylcyclopentane
- pyrimidinylcyclopentane compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- KHXLVDUXFUNEQQ-UHFFFAOYSA-N 2-cyclopentylpyrimidine Chemical class C1CCCC1C1=NC=CC=N1 KHXLVDUXFUNEQQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso para la preparación de un compuesto de fórmula (I), donde R1 es como se define en la presente, que es útil como un intermediario en la preparación de los compuestos farmacéuticos activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13193030 | 2013-11-15 | ||
| PCT/US2014/065567 WO2015073739A1 (en) | 2013-11-15 | 2014-11-13 | Processes for the preparation of pyrimidinylcyclopentane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006959A true MX2019006959A (es) | 2019-08-01 |
| MX374852B MX374852B (es) | 2025-03-06 |
Family
ID=49582648
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9862689B2 (es) |
| EP (3) | EP3656764B1 (es) |
| JP (4) | JP6374503B2 (es) |
| KR (2) | KR102698200B1 (es) |
| CN (3) | CN105899492B (es) |
| AR (1) | AR098427A1 (es) |
| AU (5) | AU2014348570B2 (es) |
| CA (2) | CA3207199A1 (es) |
| ES (2) | ES2765511T3 (es) |
| HR (2) | HRP20192340T1 (es) |
| HU (1) | HUE063095T2 (es) |
| IL (3) | IL245636B (es) |
| MX (3) | MX367620B (es) |
| MY (2) | MY174153A (es) |
| NZ (1) | NZ720805A (es) |
| PL (2) | PL3656764T3 (es) |
| RU (1) | RU2702355C1 (es) |
| SG (1) | SG10201901578UA (es) |
| SI (1) | SI3068770T1 (es) |
| WO (1) | WO2015073739A1 (es) |
| ZA (2) | ZA201603434B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105899492B (zh) * | 2013-11-15 | 2021-08-24 | 豪夫迈·罗氏有限公司 | 用于制备嘧啶基环戊烷化合物的方法 |
| CA3190507A1 (en) | 2014-09-26 | 2016-03-31 | F. Hoffmann-La Roche Ag | Processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
| CN116172869A (zh) | 2016-08-10 | 2023-05-30 | 豪夫迈·罗氏有限公司 | 包含Akt蛋白激酶抑制剂的药物组合物 |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| CN101180282B (zh) * | 2005-05-24 | 2011-09-21 | 霍夫曼-拉罗奇有限公司 | （s）-4-氟甲基-二氢-呋喃-2-酮的制备 |
| CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
| UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| KR20150041164A (ko) * | 2006-07-06 | 2015-04-15 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 억제제로서의 시클로펜타〔ｄ〕피리미딘 |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| US8853216B2 (en) | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
| AU2009204025B2 (en) | 2008-01-09 | 2014-02-20 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| PE20091364A1 (es) * | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
| JP2013528787A (ja) | 2010-04-16 | 2013-07-11 | ジェネンテック， インコーポレイテッド | Ｐｉ３ｋ／ａｋｔキナーゼ経路インヒビターの効果の予測バイオマーカーとしてのｆｏｘ０３ａ |
| EP2694072B2 (en) | 2011-04-01 | 2024-08-07 | Genentech, Inc. | Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments |
| SG11201407591PA (en) * | 2012-05-17 | 2015-01-29 | Genentech Inc | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| LT2858989T (lt) * | 2012-05-17 | 2020-08-10 | Genentech, Inc. | Akt inhibuojančio pirimidinil-ciklopentano junginio amorfinė forma, jo kompozicijos ir būdai |
| PL2861582T3 (pl) * | 2012-05-17 | 2016-11-30 | Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidynowych | |
| PL2861583T3 (pl) | 2012-05-17 | 2016-12-30 | Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny | |
| ES2668477T3 (es) | 2012-05-17 | 2018-05-18 | Genentech, Inc. | Proceso de preparación de compuestos de aminoácidos |
| CN105899492B (zh) | 2013-11-15 | 2021-08-24 | 豪夫迈·罗氏有限公司 | 用于制备嘧啶基环戊烷化合物的方法 |
| CA3190507A1 (en) | 2014-09-26 | 2016-03-31 | F. Hoffmann-La Roche Ag | Processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
-
2014
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 CN CN202110168758.6A patent/CN112898210B/zh active Active
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 KR KR1020227034215A patent/KR102698200B1/ko active Active
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-13 HR HRP20192340TT patent/HRP20192340T1/hr unknown
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en not_active Ceased
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 MX MX2020009462A patent/MX385726B/es unknown
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 MX MX2019006959A patent/MX374852B/es active IP Right Grant
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active Active
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es not_active Application Discontinuation
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2016
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
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2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
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2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
-
2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
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2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
-
2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en not_active Abandoned
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2024
- 2024-08-16 AU AU2024205845A patent/AU2024205845A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |