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MX2018003100A - Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo. - Google Patents

Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo.

Info

Publication number
MX2018003100A
MX2018003100A MX2018003100A MX2018003100A MX2018003100A MX 2018003100 A MX2018003100 A MX 2018003100A MX 2018003100 A MX2018003100 A MX 2018003100A MX 2018003100 A MX2018003100 A MX 2018003100A MX 2018003100 A MX2018003100 A MX 2018003100A
Authority
MX
Mexico
Prior art keywords
pulmonary surfactant
lysin
restore
antibacterial activity
antibiotic
Prior art date
Application number
MX2018003100A
Other languages
English (en)
Inventor
Schuch Raymond
Wittekind Michael
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2018003100A publication Critical patent/MX2018003100A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción se refiere a métodos para restaurar o aumentar la actividad bactericida de un antibiótico en un órgano o tejido en el que está presente un agente tensoactivo pulmonar. Más específicamente, la presente descripción describe que la inhibición de antibióticos debido a factores ambientales, tales como la presencia de agente tensoactivo pulmonar en un órgano o tejido tal como el epitelio respiratorio se puede eludir o superar y se restablece o aumenta la eficacia del antibiótico en ese medio por co-administración de un antibiótico y una lisina.
MX2018003100A 2015-09-17 2016-09-16 Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo. MX2018003100A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220212P 2015-09-17 2015-09-17
US201562247619P 2015-10-28 2015-10-28
PCT/US2016/052348 WO2017049242A2 (en) 2015-09-17 2016-09-16 Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby

Publications (1)

Publication Number Publication Date
MX2018003100A true MX2018003100A (es) 2019-04-15

Family

ID=57121513

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2018003101A MX2018003101A (es) 2015-09-17 2016-09-16 Activo de polipeptidos de lisina contra bacterias gram-negativas.
MX2018003100A MX2018003100A (es) 2015-09-17 2016-09-16 Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo.
MX2022006525A MX2022006525A (es) 2015-09-17 2018-03-13 Activo de polipeptidos de lisina contra bacterias gram-negativas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018003101A MX2018003101A (es) 2015-09-17 2016-09-16 Activo de polipeptidos de lisina contra bacterias gram-negativas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022006525A MX2022006525A (es) 2015-09-17 2018-03-13 Activo de polipeptidos de lisina contra bacterias gram-negativas.

Country Status (14)

Country Link
US (6) US10744189B2 (es)
EP (4) EP3349781A2 (es)
JP (3) JP7029805B2 (es)
KR (2) KR20180052754A (es)
CN (3) CN108135971A (es)
AU (3) AU2016324307B2 (es)
BR (2) BR112018005316A2 (es)
CA (2) CA2998484A1 (es)
ES (1) ES2934714T3 (es)
IL (2) IL258122B (es)
MX (3) MX2018003101A (es)
RU (2) RU2728682C2 (es)
WO (2) WO2017049233A2 (es)
ZA (2) ZA201801315B (es)

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CA2998507A1 (en) 2017-03-23
CN108348574B (zh) 2022-11-01
ZA201801315B (en) 2018-11-28
RU2728682C2 (ru) 2020-07-31
ES2934714T3 (es) 2023-02-24
JP2018534247A (ja) 2018-11-22
WO2017049233A2 (en) 2017-03-23
WO2017049242A3 (en) 2017-06-01
ZA201801316B (en) 2018-11-28
US20190290672A1 (en) 2019-09-26
EP3349781A2 (en) 2018-07-25
US20190070269A1 (en) 2019-03-07
RU2018107249A3 (es) 2020-01-10
RU2018107249A (ru) 2019-10-17
US12144845B2 (en) 2024-11-19
US11357833B2 (en) 2022-06-14
EP3349780A2 (en) 2018-07-25
CN116077630A (zh) 2023-05-09
IL258122B (en) 2020-08-31
AU2016324307B2 (en) 2021-10-21
KR20180064417A (ko) 2018-06-14
IL258123B (en) 2021-03-25
BR112018005318A2 (pt) 2018-12-11
RU2724545C2 (ru) 2020-06-23
JP2018527378A (ja) 2018-09-20
EP4151228A3 (en) 2023-06-14
CN108348574A (zh) 2018-07-31
US20220362352A1 (en) 2022-11-17
AU2016324307A1 (en) 2018-03-22
AU2022252850A1 (en) 2022-11-17
US11413334B2 (en) 2022-08-16
AU2016324298A1 (en) 2018-03-22
RU2018107245A (ru) 2019-10-18
RU2018107245A3 (es) 2019-10-18
IL258123A (en) 2018-05-31
BR112018005316A2 (pt) 2018-12-11
US20230050560A1 (en) 2023-02-16
EP4151228A2 (en) 2023-03-22
EP3349780B1 (en) 2022-11-09
IL258122A (en) 2018-05-31
US20200376096A1 (en) 2020-12-03
JP2022065075A (ja) 2022-04-26
HK1256628A1 (en) 2019-09-27
US10744189B2 (en) 2020-08-18
JP7029805B2 (ja) 2022-03-04
JP7684695B2 (ja) 2025-05-28
WO2017049233A3 (en) 2017-06-01
EP4115897A1 (en) 2023-01-11
WO2017049242A2 (en) 2017-03-23
US20250064902A1 (en) 2025-02-27
MX2018003101A (es) 2018-12-17
MX2022006525A (es) 2022-07-11
CA2998484A1 (en) 2017-03-23
KR20180052754A (ko) 2018-05-18
CN108135971A (zh) 2018-06-08
AU2016324298B2 (en) 2022-09-01

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