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MX2022006525A - Activo de polipeptidos de lisina contra bacterias gram-negativas. - Google Patents

Activo de polipeptidos de lisina contra bacterias gram-negativas.

Info

Publication number
MX2022006525A
MX2022006525A MX2022006525A MX2022006525A MX2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A
Authority
MX
Mexico
Prior art keywords
negative bacteria
lysin polypeptides
active against
against gram
gram
Prior art date
Application number
MX2022006525A
Other languages
English (en)
Inventor
Raymond Schuch
Michael Wittekind
Simon Hoffenberg
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2022006525A publication Critical patent/MX2022006525A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción proporciona métodos y composiciones útiles para la mejora profiláctica y terapéutica y tratamiento de infecciones causadas por bacterias Gram-negativas, que incluyen Pseudomonas aeruginosa. La descripción proporciona además composiciones y métodos para incorporar y utilizar polipéptidos de lisina de la presente descripción para aumentar la eficacia de antibióticos generalmente adecuados para el tratamiento de la infección bacteriana Gramnegativa.
MX2022006525A 2015-09-17 2018-03-13 Activo de polipeptidos de lisina contra bacterias gram-negativas. MX2022006525A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562220212P 2015-09-17 2015-09-17
US201562247619P 2015-10-28 2015-10-28

Publications (1)

Publication Number Publication Date
MX2022006525A true MX2022006525A (es) 2022-07-11

Family

ID=57121513

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2018003101A MX2018003101A (es) 2015-09-17 2016-09-16 Activo de polipeptidos de lisina contra bacterias gram-negativas.
MX2018003100A MX2018003100A (es) 2015-09-17 2016-09-16 Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo.
MX2022006525A MX2022006525A (es) 2015-09-17 2018-03-13 Activo de polipeptidos de lisina contra bacterias gram-negativas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2018003101A MX2018003101A (es) 2015-09-17 2016-09-16 Activo de polipeptidos de lisina contra bacterias gram-negativas.
MX2018003100A MX2018003100A (es) 2015-09-17 2016-09-16 Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo.

Country Status (14)

Country Link
US (6) US10744189B2 (es)
EP (4) EP4151228A3 (es)
JP (3) JP2018534247A (es)
KR (2) KR20180052754A (es)
CN (3) CN108135971A (es)
AU (3) AU2016324307B2 (es)
BR (2) BR112018005318A2 (es)
CA (2) CA2998507A1 (es)
ES (1) ES2934714T3 (es)
IL (2) IL258122B (es)
MX (3) MX2018003101A (es)
RU (2) RU2724545C2 (es)
WO (2) WO2017049242A2 (es)
ZA (2) ZA201801316B (es)

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JP2018534247A (ja) 2018-11-22
ZA201801315B (en) 2018-11-28
US20190070269A1 (en) 2019-03-07
JP2018527378A (ja) 2018-09-20
RU2728682C2 (ru) 2020-07-31
CA2998484A1 (en) 2017-03-23
HK1256628A1 (en) 2019-09-27
WO2017049233A2 (en) 2017-03-23
JP7029805B2 (ja) 2022-03-04
JP2022065075A (ja) 2022-04-26
US20190290672A1 (en) 2019-09-26
CN116077630A (zh) 2023-05-09
US12144845B2 (en) 2024-11-19
US20220362352A1 (en) 2022-11-17
CN108348574A (zh) 2018-07-31
JP7684695B2 (ja) 2025-05-28
US11357833B2 (en) 2022-06-14
US11413334B2 (en) 2022-08-16
US20230050560A1 (en) 2023-02-16
RU2018107249A3 (es) 2020-01-10
WO2017049242A2 (en) 2017-03-23
EP4151228A3 (en) 2023-06-14
EP4151228A2 (en) 2023-03-22
CN108135971A (zh) 2018-06-08
AU2016324307A1 (en) 2018-03-22
US20200376096A1 (en) 2020-12-03
KR20180052754A (ko) 2018-05-18
EP3349780B1 (en) 2022-11-09
WO2017049233A3 (en) 2017-06-01
EP3349780A2 (en) 2018-07-25
WO2017049242A3 (en) 2017-06-01
ZA201801316B (en) 2018-11-28
RU2018107245A3 (es) 2019-10-18
US10744189B2 (en) 2020-08-18
CA2998507A1 (en) 2017-03-23
EP4115897A1 (en) 2023-01-11
KR20180064417A (ko) 2018-06-14
AU2016324298B2 (en) 2022-09-01
RU2018107245A (ru) 2019-10-18
RU2724545C2 (ru) 2020-06-23
IL258123A (en) 2018-05-31
BR112018005318A2 (pt) 2018-12-11
CN108348574B (zh) 2022-11-01
MX2018003101A (es) 2018-12-17
RU2018107249A (ru) 2019-10-17
ES2934714T3 (es) 2023-02-24
AU2016324307B2 (en) 2021-10-21
AU2016324298A1 (en) 2018-03-22
IL258122A (en) 2018-05-31
MX2018003100A (es) 2019-04-15
BR112018005316A2 (pt) 2018-12-11
IL258122B (en) 2020-08-31
AU2022252850A1 (en) 2022-11-17
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US20250064902A1 (en) 2025-02-27
IL258123B (en) 2021-03-25

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